Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group.
Chevalley, Thierry; Brandi, Maria Luisa; Cashman, Kevin Det al.
2022 • In Aging Clinical and Experimental Research, 34 (11), p. 2603 - 2623
Falls; Fragility fracture; Osteoarthritis; Vitamin D; Calcifediol; Vitamins; Bone Density Conservation Agents; Humans; Aged; Vitamins/therapeutic use; Dietary Supplements/adverse effects; Vitamin D Deficiency/epidemiology; Osteoporosis/drug therapy; Bone Density Conservation Agents/therapeutic use; Fractures, Bone/prevention & control; Osteoarthritis/drug therapy; Dietary Supplements; Fractures, Bone; Osteoporosis; Vitamin D Deficiency; Aging; Geriatrics and Gerontology
Abstract :
[en] Vitamin D is a key component for optimal growth and for calcium-phosphate homeostasis. Skin photosynthesis is the main source of vitamin D. Limited sun exposure and insufficient dietary vitamin D supply justify vitamin D supplementation in certain age groups. In older adults, recommended doses for vitamin D supplementation vary between 200 and 2000 IU/day, to achieve a goal of circulating 25-hydroxyvitamin D (calcifediol) of at least 50 nmol/L. The target level depends on the population being supplemented, the assessed system, and the outcome. Several recent large randomized trials with oral vitamin D regimens varying between 2000 and 100,000 IU/month and mostly conducted in vitamin D-replete and healthy individuals have failed to detect any efficacy of these approaches for the prevention of fracture and falls. Considering the well-recognized major musculoskeletal disorders associated with severe vitamin D deficiency and taking into account a possible biphasic effects of vitamin D on fracture and fall risks, an European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group convened, carefully reviewed, and analyzed the meta-analyses of randomized controlled trials on the effects of vitamin D on fracture risk, falls or osteoarthritis, and came to the conclusion that 1000 IU daily should be recommended in patients at increased risk of vitamin D deficiency. The group also addressed the identification of patients possibly benefitting from a vitamin D loading dose to achieve early 25-hydroxyvitamin D therapeutic level or from calcifediol administration.
Disciplines :
Public health, health care sciences & services General & internal medicine
Author, co-author :
Chevalley, Thierry ; Service of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. Thierry.chevalley@hcuge.ch
Brandi, Maria Luisa; Metabolic Bone Diseases Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
Cashman, Kevin D; Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland
Cavalier, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chimie clinique
Harvey, Nicholas C; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK ; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK
Cooper, Cyrus; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK ; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK ; UKNIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
Al-Daghri, Nasser; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science King Saud University, Riyadh, 11451, Saudi Arabia
Bock, Oliver; Department of Osteoporosis, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland ; International Osteoporosis Foundation, Nyon, Switzerland
Bruyère, Olivier ; Division of Public Health, Epidemiology and Health Economics, WHO Collaborating Center for Public Health Aspects of Musculo-Skeletal Health and Ageing, University of Liège, Liege, Belgium
Rosa, Mario Miguel; Centro de Estudos Egas Moniz Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
Cortet, Bernard; Department of Rheumatology, University of Lille, CHU Lille, MABlab ULR 4490, Lille, France
Cruz-Jentoft, Alfonso J; Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain
Cherubini, Antonio; Dipartimento dei percorsi geriatrici della fragilità, Geriatria, Accettazione geriatrica e Centro di ricerca per l'invecchiamentodella continuità di cura e riabilitativi, IRCCS INRCA, Ancona, Italy
Dawson-Hughes, Bess; Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Fielding, Roger; Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Fuggle, Nicholas; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK ; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK
Halbout, Philippe; International Osteoporosis Foundation, Nyon, Switzerland
Kanis, John A; Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK ; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia
Kaufman, Jean-Marc; Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Lamy, Olivier ; Bone Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Laslop, Andrea; Scientific Office, Federal Office for Safety in Health Care, Austrian Medicines and Medical Devices Agency, Vienna, Austria
Yerro, Maria Concepción Prieto; Spanish Agency for Medicines and Medical Devices, Madrid, Spain
Radermecker, Régis ; Centre Hospitalier Universitaire de Liège - CHU > > Service de diabétologie, nutrition, maladies métaboliques
Thiyagarajan, Jotheeswaran Amuthavalli; Ageing and Health Unit, Department of Maternal, Newborn, Child and Adolescent Health & Ageing, WHO HQ, Geneva, Switzerland
Thomas, Thierry; Department of Rheumatology, North Hospital, CHU Saint-Etienne and INSERM U1059, University of Lyon-University Jean Monnet, Saint-Etienne, France
Veronese, Nicola; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy
de Wit, Marten; Department of Medical Humanities, Amsterdam University Medical Centre, Amsterdam, The Netherlands
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique
Rizzoli, René; Service of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group.
Publication date :
November 2022
Journal title :
Aging Clinical and Experimental Research
ISSN :
1594-0667
eISSN :
1720-8319
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
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