Asthma; PROM; Quality of life; Symptoms; Pulmonary and Respiratory Medicine
Abstract :
[en] Many studies exploring the factors associated with asthma-specific quality of life (QOL) have shown that asthma control is the main predictor of asthma-related QOL. However, to the best of our knowledge, no study has ever explored the individual impact of the five main symptoms of asthma (wheezing, dyspnea, chest tightness, cough and airway secretion) reported directly by the patient on asthma-related QOL. A cross-sectional study was conducted on untreated adult (≥18 years) asthmatics recruited from the Liege University Hospital Asthma Clinic (Belgium) for asthma diagnosis confirmation between 2018 and 2021 (n = 171). Multiple linear regression analysis demonstrated that dyspnea and chest tightness were the two leading factors associated with asthma-related QOL in a population of mild asthma.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Louis, Gilles ; Université de Liège - ULiège > Santé publique : de la Biostatistique à la Promotion de la Santé
Schleich, FLorence ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Louis, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Guillaume, Michèle ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique : aspects spécifiques
Sousa-Pinto, Bernardo; Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal
Bousquet, Jean; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany, University Hospital Montpellier, France
Pétré, Benoît ; Université de Liège - ULiège > Département des sciences de la santé publique > Education thérapeutique du patient au service des soins intégrés
Language :
English
Title :
How respiratory symptoms impact asthma-related quality of life in mild asthmatics.
Louis, G., Pétré, B., Charlier, N., Voz, B., Guillaume, M., Quality of life in the medical field : a brief overview of its origin, semantics, measuring instruments and clinical use. Rev. Med. Liege 76:9 (2021), 689–696 http://europepmc.org/abstract/MED/34477341.
Juniper, E.F., Wisniewski, M.E., Cox, F.M., Emmett, A.H., Nielsen, K.E., O'Byrne, P.M., Relationship between quality of life and clinical status in asthma: a factor analysis. Eur. Respir. J. 23:2 (2004), 287–291, 10.1183/09031936.04.00064204.
GLOBAL STRATEGY for ASTHMA MANAGEMENT and PREVENTION Updated 2020, 2020 www.ginasthma.org. (Accessed 21 August 2020)
National Asthma Education and Prevention Program TEP on the D and M of A. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma., 2007 https://www.ncbi.nlm.nih.gov/books/NBK7232/. (Accessed 9 September 2021)
Stucky, B.D., Sherbourne, C.D., Edelen, M.O., Eberhart, N.K., Understanding asthma-specific quality of life: moving beyond asthma symptoms and severity. Eur. Respir. J. 46:3 (2015), 680–687, 10.1183/09031936.00225014.
Chen, H., Gould, M.K., Blanc, P.D., et al. Asthma control, severity, and quality of life: quantifying the effect of uncontrolled disease. J. Allergy Clin. Immunol. 120:2 (2007), 396–402, 10.1016/j.jaci.2007.04.040.
Louis, G., Pétré, B., Schleich, F., et al. Predictors of asthma‐related quality of life in a large cohort of asthmatics: a cross‐sectional study in a secondary care center. Clin. Transl. Allergy, 11(7), 2021, e12054, 10.1002/clt2.12054.
Louis, R., Bougard, N., Guissard, F., Paulus, V., Henket, M., Schleich, F., Bronchodilation test with inhaled salbutamol versus bronchial methacholine challenge to make an asthma diagnosis: do they provide the same information?. J. Allergy Clin. Immunol. Pract. 8:2 (2020), 618–625, 10.1016/j.jaip.2019.09.007 e8.
Juniper, E.F., Guyatt, G.H., Cox, F.M., Ferrie, P.J., King, D.R., Development and validation of the mini asthma quality of life questionnaire. Eur. Respir. J. 14:1 (1999), 32–38, 10.1034/j.1399-3003.1999.14a08.x.
Moy, M.L., Israel, E., Weiss, S.T., Juniper, E.F., Dubé, L., Drazen, J.M., Clinical predictors of health-related quality of life depend on asthma severity. Am. J. Respir. Crit. Care Med. 163:4 (2001), 924–929, 10.1164/ajrccm.163.4.2008014.
Natarajan, S., Free, R.C., Bradding, P., McGarvey, L., Siddiqui, S., The relationship between the Leicester cough questionnaire, eosinophilic airway inflammation and asthma patient related outcomes in severe adult asthma. Respir. Res. 18:1 (2017), 1–6, 10.1186/s12931-017-0520-2.
Louis, G., Schleich, F., Guillaume, M., et al. Are asthma symptom intensity scales better than biomarkers for diagnosing asthma? A prospective observational study. Eur. Respir. J., 58, 2021, PA1140, 10.1183/13993003.congress-2021.pa1140 European Respiratory Society (ERS).
Asher, M.I., Weiland, S.K., The international study of asthma and allergies in childhood (ISAAC). Clin. Exp. Allergy Suppl. 28 (1998), 52–66, 10.1046/j.1365-2222.1998.028s5052.x Blackwell Publishing Ltd.
Louis, R., Satia, I., Ojanguren, I., et al. European respiratory society guidelines for the diagnosis of asthma in adults. Eur. Respir. J., 2022, 2101585, 10.1183/13993003.01585-2021.
