Article (Scientific journals)
Cell "circadian" cycle: new role for mammalian core clock genes.
Borgs, Laurence; Beukelaers, Pierre; Vandenbosch, Renaud et al.
2009In Cell Cycle, 8 (6), p. 832-7
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Keywords :
Animals; Biological Clocks/genetics/physiology; Cell Cycle/genetics/physiology; Cell Cycle Proteins/genetics/metabolism; Circadian Rhythm/genetics/physiology; DNA Damage/genetics/physiology; Humans; Signal Transduction/genetics/physiology; Trans-Activators/genetics/metabolism; Transcription Factors/genetics/metabolism
Abstract :
[en] In mammals, 24 hours rhythms are organized as a biochemical network of molecular clocks that are operative in all tissues, with the master clock residing in the hypothalamic suprachiasmatic nucleus (SCN). The core pacemakers of these clocks consist of auto-regulatory transcriptional/post-transcriptional feedback loops. Several lines of evidence suggest the existence of a crosstalk between molecules that are responsible for the generation of circadian rhythms and molecules that control the cell cycle progression. In addition, highly specialized cell cycle checkpoints involved in DNA repair after damage seem also, at least in part, mediated by clock proteins. Recent studies have also highlighted a putative connection between clock protein dysfunction and cancer progression. This review discusses the intimate relation that exists between cell cycle progression and components of the circadian machinery.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Neurology
Author, co-author :
Borgs, Laurence ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Beukelaers, Pierre ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
Vandenbosch, Renaud  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Belachew, Shibeshih ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Nguyen, Laurent  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Malgrange, Brigitte  ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. - Neurologie
Language :
English
Title :
Cell "circadian" cycle: new role for mammalian core clock genes.
Publication date :
2009
Journal title :
Cell Cycle
ISSN :
1538-4101
eISSN :
1551-4005
Publisher :
Landes Bioscience, Georgetown, United States - Texas
Volume :
8
Issue :
6
Pages :
832-7
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
DGTRE - Région wallonne. Direction générale des Technologies, de la Recherche et de l'Énergie [BE]
Fonds Léon Fredericq [BE]
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