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Retinoic Acid Stimulates Regeneration of Mammalian Auditory Hair Cells
Lefèbvre, Philippe; Malgrange, Brigitte; Staecker, H. et al.
1993In Science, 260 (5108), p. 692-5
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Keywords :
cochlea; inner ear; regeneration
Abstract :
[en] Sensorineural hearing loss resulting from the loss of auditory hair cells is thought to be irreversible in mammals. This study provides evidence that retinoic acid can stimulate the regeneration in vitro of mammalian auditory hair cells in ototoxic-poisoned organ of Corti explants in the rat. In contrast, treatment with retinoic acid does not stimulate the formation of extra hair cells in control cultures of Corti's organ. Retinoic acid-stimulated hair cell regeneration can be blocked by cytosine arabinoside, which suggests that a period of mitosis is required for the regeneration of auditory hair cells in this system. These results provide hope for a recovery of hearing function in mammals after auditory hair cell damage.
Disciplines :
Biochemistry, biophysics & molecular biology
Otolaryngology
Author, co-author :
Lefèbvre, Philippe ;  Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie
Malgrange, Brigitte  ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
Staecker, H.
Moonen, Gustave  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine
Van de Water, T. R.
Language :
English
Title :
Retinoic Acid Stimulates Regeneration of Mammalian Auditory Hair Cells
Publication date :
30 April 1993
Journal title :
Science
ISSN :
0036-8075
eISSN :
1095-9203
Publisher :
American Association for the Advancement of Science, Washington, United States - District of Columbia
Volume :
260
Issue :
5108
Pages :
692-5
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 27 November 2009

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