[en] ("[en] BACKGROUND: The severity of endoscopic recurrence during the first year after intestinal resection for Crohn's disease is predictive of clinical recurrence. The aim of our study was to assess the impact of the implementation of an ileocolonoscopy during the first year after surgery on surgical recurrence.
METHODS: All patients who underwent a first intestinal resection for Crohn's disease between 1992 and 2018 at the University Hospital of Liège were retrospectively included. The time to surgical recurrence was compared in three successive groups of patients operated on in the period 1992-2001 (group A), 2002-2011 (group B), and 2012-2020 (group C) using the Kaplan-Meier method and the Log-Rank test. To identify independent prognostic factors, a multivariate analysis was used via the Cox model.
RESULTS: 223 patients (group A = 69, group B = 94, group C = 60) were included. Probabilities of surgical recurrence were significantly lower in group C (2.2% and 4.7% at 3 and 5 years, respectively) compared with group B (4.2% and 7.6% at 3 and 5 years, respectively) and with group A (9% and 18.2% at 3 and 5 years, respectively) (p = 0.0089). Ileocolonoscopy during the year after surgery was associated with a significantly reduced surgical recurrence rate in univariate and multivariate analysis (HR = 0.31, p = 0.0049).
CONCLUSION: The implementation of an early ileocolonoscopy after surgery for Crohn's disease since early 2000 has been associated with a reduced surgical recurrence over the last 30 years.","[en] ","")
Disciplines :
Gastroenterology & hepatology
Author, co-author :
AMICONE, Caroline ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Marques, Carla Coimbra ; Departement of Abdominal and Transplantation Surgery, Centre Hospitalier Universitaire de Liège, Liège, Belgium
Reenaers, Catherine ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Van Kemseke, Catherine ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Seidel, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
Louis, Edouard ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Language :
English
Title :
Early Post-Operative Endoscopy Is Associated with Lower Surgical Recurrence of Crohn's Disease: A Retrospective Study of Three Successive Cohorts.
Freeman H. J., Long-Term natural history of Crohn's disease. World Journal of Gastroenterology 2009, 15, 11, 1315, 1318, 10.3748/wjg.15.1315, 2-s2.0-65649143414, 19294760
Peyrin-Biroulet L., Loftus E. V., Colombel J.-F., Sandborn W. J., The natural history of adult Crohn's disease in population-based cohorts. The American Journal of Gastroenterology 2010, 105, 2, 289, 297, 10.1038/ajg.2009.579, 2-s2.0-76349114941, 19861953
Bemelman W. A., Warusavitarne J., Sampietro G. M., Serclova Z., Zmora O., Luglio G., ECCO-ESCP consensus on surgery for Crohn's disease. Journal of Crohn's and Colitis 2018, 12, 1, 16
Olivera P., Spinelli A., Gower-Rousseau C., Danese S., Peyrin-Biroulet L., Surgical rates in the era of biological therapy? Current Opinion in Gastroenterology 2017, 33, 4, 246, 253, 10.1097/MOG.0000000000000361, 2-s2.0-85020377673
Swoger J., Regueiro M., Preventive therapy in postoperative Crohns disease. Current Opinion in Gastroenterology 2010, 26, 4, 337, 343, 10.1097/MOG.0b013e328338f724, 2-s2.0-77954111733
Colombel J.-F., Rutgeerts P., Malchow H., Jacyna M., Nielsen O. H., Rask-Madsen J., van Deventer S., Ferguson A., Desreumaux P., Forbes A., Geboes K., Melani L., Cohard M., Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease. Gut 2001, 49, 1, 42, 46, 10.1136/gut.49.1.42, 2-s2.0-0034956334, 11413109
Rutgeerts P., Geboes K., Vantrappen G., Beyls J., Kerremans R., Hiele M., Predictability of the postoperative course of Crohn's disease. Gastroenterology 1990, 99, 4, 956, 963, 10.1016/0016-5085(90)90613-6, 2-s2.0-0025013473, 2394349
Siew C., Kamm M., Management of postoperative Crohn's disease. American Journal of Gastroenterology 2008, 103, 4, 1029, 1035, 10.1111/j.1572-0241.2008.01795.x, 2-s2.0-41849084126
Van Assche G., Dignass A., Reinisch W., Van Assche G., Dignass A., Reinisch W., van der Woude C. J., Sturm A., De Vos M., Guslandi M., Oldenburg B., Dotan I., Marteau P., Ardizzone A., Baumgart D. C., D'Haens G., Gionchetti P., Portela F., Vucelic B., Söderholm J., Escher J., Koletzko S., Kolho K.-L., Lukas M., Mottet C., Tilg H., Vermeire S., Carbonnel F., Cole A., Novacek G., Reinshagen M., Tsianos E., Herrlinger K., Oldenburg B., Bouhnik Y., Kiesslich R., Stange E., Travis S., Lindsay J., The second European evidence-based consensus on the diagnosis and management of Crohn's disease: special situations. Journal of Crohn's and Colitis 2010, 4, 1, 63, 101, 10.1016/j.crohns.2009.09.009, 2-s2.0-75149116327, 21122490
Rutgeerts P., Geboes K., Vantrappen G., Kerremans R., Coenegrachts J. L., Coremans G., Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut 1984, 25, 6, 665, 672, 10.1136/gut.25.6.665, 2-s2.0-0021266269, 6735250
Baudry C., Pacault V., Simon M., Gornet J. M., Cattan P., Munoz-Bongrand N., Sarfati E., Allez M., Lémann M., P.174 Intérêt de la coloscopie systématique dans l'année suivant une résection chirurgicale pour la prévention de la récidive dans la maladie de Crohn. Gastroentérologie Clinique et Biologique 2009, 33, 3, A105, 10.1016/S0399-8320(09)72805-2
De Cruz P., Kamm M. A., Hamilton A. L., Ritchie K. J., Krejany E. O., Gorelik A., Liew D., Prideaux L., Lawrance I. C., Andrews J. M., Bampton P. A., Gibson P. R., Sparrow M., Leong R. W., Florin T. H., Gearry R. B., Radford-Smith G., Macrae F. A., Debinski H., Selby W., Kronborg I., Johnston M. J., Woods R., Elliott P. R., Bell S. J., Brown S. J., Connell W. R., Desmond P. V., Crohn's disease management after intestinal resection: A randomised trial. Lancet Lond Engl 2015, 385, 9976, 1406, 1417, 10.1016/S0140-6736(14)61908-5, 2-s2.0-84928704222, 25542620
Pariente B., Torres J., Burisch J., Arebi N., Barberio B., Duricova D., Ellul P., Goldis A., Kaimakliotis I., Katsanos K., Krznaric Ž., McNamara D., Pedersen N., Sebastian S., Azahaf M., Weimers P., Lung P., Lacognata C., Horak M., Christodoulou D., Domislovic V., Murphy I., Lambert J., Ungaro R., Colombel J. F., Mary J. Y., Validation and update of the Lémann index to measure cumulative structural bowel damage in Crohn's disease. Gastroenterology 2021, 161, 3, 853, 864.e13, 10.1053/j.gastro.2021.05.049, 34052277
Yamamoto T., Factors affecting recurrence after surgery for Crohn's disease. World Journal of Gastroenterology 2005, 11, 26, 3971, 3979, 10.3748/wjg.v11.i26.3971, 2-s2.0-24144475465, 15996018
King D., Coupland B., Dosanjh A., Cole A., Adderley N. J., Reulen R. C., Patel P., Trudgill N. J., The risk of later surgery at the anastomotic site following right hemicolectomy for Crohn's disease in a national cohort of 12 230 patients. Alimentary Pharmacology & Therapeutics 2021, 53, 1, 114, 127, 10.1111/apt.16114, 33086430
Candia R., Bravo-Soto G. A., Monrroy H., Hernandez C., Nguyen G. C., Colonoscopy-guided therapy for the prevention of post-operative recurrence of Crohn's disease. Cochrane Database of Systematic Reviews 2020, 8, 8
Gionchetti P., Dignass A., Danese S., Magro Dias F. J., Rogler G., Lakatos P. L., Adamina M., Ardizzone S., Buskens C. J., Sebastian S., Laureti S., Sampietro G. M., Vucelic B., van der Woude C. J., Barreiro-de Acosta M., Maaser C., Portela F., Vavricka S. R., Gomollón F., On behalf of ECCO, 3rdEuropean evidence-based consensus on the diagnosis and management of Crohn's disease 2016: part 2: surgical management and special situations. Journal of Crohn's and Colitis 2017, 11, 2, 135, 149, 10.1093/ecco-jcc/jjw169, 2-s2.0-85014294059, 27660342,
Nos P., Domènech E., Postoperative Crohn's disease recurrence: A practical approach. World Journal of Gastroenterology 2008, 14, 36, 5540, 5548, 10.3748/wjg.14.5540, 2-s2.0-58149192819, 18810773
Breuer-Katschinski B. D., Hollander N., Goebell H., Effect of cigarette smoking on the course of Crohn's disease. European Journal of Gastroenterology & Hepatology 1996, 8, 3, 225, 228, 10.1097/00042737-199603000-00007, 2-s2.0-0029998730, 8724021
Reese G. E., Nanidis T., Borysiewicz C., Yamamoto T., Orchard T., Tekkis P. P., The effect of smoking after surgery for Crohn's disease: A meta-Analysis of observational studies. International Journal of Colorectal Disease 2008, 23, 12, 1213, 1221, 10.1007/s00384-008-0542-9, 2-s2.0-56749105799, 18762954
Collins M., Sarter H., Gower-Rousseau C., Koriche D., Libier L., Nachury M., Cortot A., Zerbib P., Blanc P., Desreumaux P., Colombel J. F., Peyrin-Biroulet L., Pineton de Chambrun G., Previous exposure to multiple anti-TNF is associated with decreased efficiency in preventing postoperative Crohn's disease recurrence. Journal of Crohn's and Colitis 2017, 11, 3, 281, 288, 10.1093/ecco-jcc/jjw151, 2-s2.0-85032966616, 27578800
Van Loo E. S., Dijkstra G., Ploeg R. J., Nieuwenhuijs V. B., Prevention of postoperative recurrence of Crohn's disease. Journal of Crohn's and Colitis 2012, 6, 6, 637, 646, 10.1016/j.crohns.2011.12.006, 2-s2.0-84862168533
Hellers G., Cortot A., Jewell D., Leijonmarck C. E., Löfberg R., Malchow H., Nilsson L. G., Pallone F., Pena S., Persson T., Prantera C., Rutgeerts P., Oral budesonide for prevention of postsurgical recurrence in Crohn's disease. The IOIBD Budesonide Study Group. Gastroenterology 1999, 116, 2, 294, 300
Olaison G., Smedh K., Sjodahl R., Natural course of Crohn's disease after ileocolic resection: endoscopically visualised ileal ulcers preceding symptoms. Gut 1992, 33, 3, 331, 335, 10.1136/gut.33.3.331, 1568651
De Cruz P., Bernardi M.-P., Kamm M. A., Allen P. B., Prideaux L., Williams J., Johnston M. J., Keck J., Brouwer R., Heriot A., Woods R., Brown S., Bell S. J., Elliott R., Connell W. R., Desmond P. V., Postoperative recurrence of Crohn's disease: impact of endoscopic monitoring and treatment step-up. Colorectal Disease 2013, 15, 2, 187, 197, 10.1111/j.1463-1318.2012.03168.x, 2-s2.0-84870631250, 22757652
Lochs H., Mayer M., Fleig W. E., Mortensen P. B., Bauer P., Genser D., Petritsch W., Raithel M., Hoffmann R., Gross V., Plauth M., Staun M., Nesje L. B., Prophylaxis of postoperative relapse in Crohn's disease with mesalamine: European Cooperative Crohn's Disease Study IV. Gastroenterology 2000, 118, 2, 264, 273, 10.1016/S0016-5085(00)70208-3, 2-s2.0-0033965199, 10648454
De Cruz P., Kamm M. A., Hamilton A. L., Ritchie K. J., Krejany E. O., Gorelik A., Liew D., Prideaux L., Lawrance I. C., Andrews J. M., Bampton P. A., Jakobovits S., Florin T. H., Gibson P. R., Debinski H., Gearry R. B., Macrae F. A., Leong R. W., Kronborg I., Radford-Smith G., Sel W., Efficacy of thiopurines and adalimumab in preventing Crohn's disease recurrence in high-risk patients-A POCER study analysis. Alimentary Pharmacology & Therapeutics 2015, 42, 7, 867, 879, 10.1111/apt.13353, 2-s2.0-84940793606, 26314275
Regueiro M., Schraut W., Baidoo L., Kip K. E., Sepulveda A. R., Pesci M., Harrison J., Plevy S. E., Infliximab prevents Crohn's disease recurrence after ileal resection. Gastroenterology 2009, 136, 2, 441, 450, 10.1053/j.gastro.2008.10.051, 2-s2.0-58649121974, 19109962
Regueiro M., Feagan B. G., Zou B., Johanns J., Blank M. A., Chevrier M., Plevy S., Popp J., Cornillie F. J., Lukas M., Danese S., Gionchetti P., Hanauer S. B., Reinisch W., Sandborn W. J., Sorrentino D., Rutgeerts P., Debinski H., Florin T., Hetzel D., Lawrance I., Radford-Smith G., Sloss A., Sorrentino D., Gassner S., Haas T., Reicht G., Reinisch W., Strasser M., Vogelsang H., Bossuyt P., DeWit O., D'Haens G., Franchimont D., Louis E., Vermeire S., Bernstein C. N., Bourdages R., Chiba N., Dhalla S. S., Feagan B. G., Fedorak R. N., Lachance J. R., Panaccione R., Ropeleski M., Singh Salh B., Lukas M., Colombel J. F., Allez M., Desreumaux P., Dupas J. L., Grimaud J. C., Hebuterne X., Laharie D., Lerebours E., Peyrin-Biroulet L., Reimund J. M., Viennot S., Zerbib F., Antoni C., Atreya R., Baumgart D. C., Berg C., Boecker U., Bramkamp G., Bünning C., Ehehalt R., Howaldt S., Kucharzik T., Lamprecht H. G., Mudter J., Preiss J. C., Schreiber S., Seidler U., Altorjay I., Banai J., Lakatos P. L., Varga M., Vincze A., Avni-Biron I., Fishman S., Fraser G. M., Goldin E., Rachmilewitz D., Annese V., Ardizzone S., Biancone L., Bossa F., Danese S., Fries W., Gionchetti P., Maconi G., Terrosu G., Usai P., D'Haens G. R., Gearry R. B., Hill J., Rowbotham D. S., Schultz M., Stubbs R. S., Wallace D., Walmsley R. S., Wyeth J., Malecka-Panas E., Paradowski L., Regula J., Beales I. P., Campbell S., Hawthorne A. B., Parkes M., Travis S. P., Achkar J. P., Behm B. W., Bickston S. J., Brown K. J., Chiorean M. V., DeVilliers W. J. S., Elliott D. E., Grunkmeier D., Hamilton J. W., Hanauer S. B., Hanson J. S., Hardi R., Helper D. J., Herfarth H., Higgins P. D. R., Holderman W. H., Kottoor R., Kreines M. D., Leman B. I., Li X., Loftus E. V. Jr., Noar M., Oikonomou I., Onken J., Peterson K. A., Phillips R. P., Randall C. W., Ricci M., Ritter T., Rubin D. T., Safdi M., Sandborn W. J., Sauberman L., Scherl E., Schwarz R. P., Sedghi S., Shafran I., Sninsky C. A., Stein I., Swoger J., Vecchio J., Weinberg D. I., Wruble L. D., Yajnik V., Younes Z., Infliximab reduces endoscopic, but not clinical, recurrence of Crohn's disease after ileocolonic resection. Gastroenterology 2016, 150, 7, 1568, 1578, 10.1053/j.gastro.2016.02.072, 2-s2.0-84975815690
Yamamoto T., Umegae S., Matsumoto K., Impact of infliximab therapy after early endoscopic recurrence following ileocolonic resection of Crohn's disease: A prospective pilot study. Inflamm Bowel 2009, 15, 10, 1460, 1466, 10.1002/ibd.20915, 2-s2.0-70450175693, 19266566
López-Sanromán A., Vera-Mendoza I., Domènech E., Taxonera C., Vega Ruiz V., Marín-Jiménez I., Guardiola J., Castro L., Esteve M., Iglesias E., Ceballos D., Martínez-Montiel P., Gisbert J. P., Mínguez M., Echarri A., Calvet X., Barrio J., Hinojosa J., Martín-Arranz M. D., Márquez-Mosquera L., Bermejo F., Rimola J., Pons V., Nos P., on behalf of the Spanish GETECCU group [APPRECIA study], Adalimumab vs azathioprine in the prevention of postoperative Crohn's disease recurrence. A GETECCU randomised trial. Journal of Crohn's and Colitis 2017, 11, 11, 1293, 1301, 10.1093/ecco-jcc/jjx051, 2-s2.0-85033383027, 28402454
Barnes E. L., Lightner A. L., Regueiro M., Peri-operative and post-operative management of patients with Crohn's disease and ulcerative colitis. Clinical Gastroenterology and Hepatology 2020, 18, 6, 1356, 1366, 10.1016/j.cgh.2019.09.040, 31589972
Burr N. E., Hall B., Hamlin P. J., Selinger C. P., Ford A. C., O'Connor A., Systematic review and network meta-Analysis of medical therapies to prevent recurrence of post-operative Crohn's disease. Journal of Crohn's & Colitis 2019, 13, 6, 693, 701, 10.1093/ecco-jcc/jjy216, 2-s2.0-85066929363, 30561586
Regueiro M., Kip K. E., Baidoo L., Swoger J. M., Schraut W., Post-operative therapy with infliximab prevents long-Term Crohn's disease recurrence. Clinical Gastroenterology and Hepatology 2014, 12, 9, 1494, 1502.e1, 10.1016/j.cgh.2013.12.035, 2-s2.0-84906790991, 24440221