[en] Alzheimer's disease (AD) represents a major health and societal issue; there is no treatment to date and the pathophysiological mechanisms underlying this disease are not well understood. Yet, there is hope that AD risk factors and thus the number of AD cases can be significantly reduced by prevention measures based on lifestyle modifications as targeted by non-pharmacological preventive interventions. So far, these interventions have rarely targeted the psycho-affective risk factors related to depression, stress, anxiety, and feeling of loneliness, which are all prevalent in ageing. This paper presents the hypothesis that the regular practice of mindfulness meditation (MM) and loving-kindness and compassion meditation (LKCM) in the ageing population constitutes a lifestyle that is protective against AD. In this model, these practices can promote cognition, mental health, and well-being by strengthening attention control, metacognitive monitoring, emotion regulation and pro-social capacities. Training these capacities could reduce the risk of AD by upregulating beneficial age-related factors such as cognitive reserve, and down-regulating detrimental age-related factors, such as stress, or depression. As an illustration, we present the Medit-Ageing study (public name Silver Santé Study), an on-going European project that assesses the impact and mechanisms of non-pharmacological interventions including meditation, in the ageing population.
Disciplines :
Neurosciences & behavior
Author, co-author :
Lutz, Antoine; Lyon Neuroscience Research Center Inserm U1028, CNRS UMR5292, Lyon 1 University,
Collette, Fabienne ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Klimecki, Olga ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie ; Institute of Clinical Psychology and Psychotherapy, TU Dresden, Germany.
Marchant, Natalie L; Division of Psychiatry, University College London, London, United Kingdom.
Acevedo, B.P., Pospos, S., Lavretsky, H., The neural mechanisms of meditative practices: novel approaches for healthy aging. Curr. Behav. Neurosci. Rep. 3 (2016), 328–339, 10.1007/s40473-016-0098-x.
Bannon, S.M., Grunberg, V.A., Reichman, M., Popok, P.J., Traeger, L., Dickerson, B.C., Vranceanu, A.-M., Thematic analysis of dyadic coping in couples with young-onset dementia. JAMA Netw. Open, 4, 2021, e216111, 10.1001/jamanetworkopen.2021.6111.
Barnhofer, T., Mindfulness training in the treatment of persistent depression: can it help to reverse maladaptive plasticity?. Curr. Opin. Psychol. Mindfulness 28 (2019), 262–267, 10.1016/j.copsyc.2019.02.007.
Barnhofer, T., Chittka, T., Nightingale, H., Visser, C., Crane, C., State effects of two forms of meditation on prefrontal EEG asymmetry in previously depressed individuals. Mindfulness 1 (2010), 21–27, 10.1007/s12671-010-0004-7.
Berk, L., van Boxtel, M., van Os, J., Can mindfulness-based interventions influence cognitive functioning in older adults? A review and considerations for future research. Aging Ment. Health 21 (2017), 1113–1120, 10.1080/13607863.2016.1247423.
Carrié, I., van Kan, G.A., Gillette-Guyonnet, S., Andrieu, S., Dartigues, J.-F., Touchon, J., Dantoine, T., Rouaud, O., Bonnefoy, M., Robert, P., Cuffi, M.-N., Bories, L., Bordes, S., Gasnier, Y., Desclaux, F., Sudres, K., Pesce, A., Vellas, B., Recruitment strategies for preventive trials. The MAPT study (MultiDomain Alzheimer Preventive Trial). J. Nutr. Health Aging 16 (2012), 355–359, 10.1007/s12603-012-0046-8.
Chaix, R., Alvarez-López, M.J., Fagny, M., Lemee, L., Regnault, B., Davidson, R.J., Lutz, A., Kaliman, P., Epigenetic clock analysis in long-term meditators. Psychoneuroendocrinology 85 (2017), 210–214, 10.1016/j.psyneuen.2017.08.016.
Chételat, G., Lutz, A., Arenaza-Urquijo, E., Collette, F., Klimecki, O., Marchant, N., Why could meditation practice help promote mental health and well-being in aging?. Alzheimer's Res. Ther., 10, 2018, 57, 10.1186/s13195-018-0388-5.
Chételat, G., Mézenge, F., Tomadesso, C., Landeau, B., Arenaza-Urquijo, E., Rauchs, G., André, C., de Flores, R., Egret, S., Gonneaud, J., Poisnel, G., Chocat, A., Quillard, A., Desgranges, B., Bloch, J.-G., Ricard, M., Lutz, A., Reduced age-associated brain changes in expert meditators: a multimodal neuroimaging pilot study. Sci. Rep., 7, 2017, 10160, 10.1038/s41598-017-07764-x.
Cotier, F.A., Zhang, R., Lee, T.M.C., A longitudinal study of the effect of short-term meditation training on functional network organization of the aging brain. Sci. Rep., 7, 2017, 598, 10.1038/s41598-017-00678-8.
Dahl, et al. The plasticity of well-being: A training-based framework for the cultivation of human flourishing. Proceedings of the National Academy of Sciences, 117(51), 2020, 10.1073/pnas.2014859117.
Dahl, C.J., Lutz, A., Davidson, R.J., Reconstructing and deconstructing the self: cognitive mechanisms in meditation practice. Trends Cogn. Sci. 19 (2015), 515–523, 10.1016/j.tics.2015.07.001.
Deckers, K., Köhler, S., Ngandu, T., Antikainen, R., Laatikainen, T., Soininen, H., Strandberg, T., Verhey, F., Kivipelto, M., Solomon, A., Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index. Alzheimers Dement. 17 (2021), 1205–1212, 10.1002/alz.12281.
Dimidjian, S., Segal, Z.V., Prospects for a clinical science of mindfulness-based interventions. Am. Psychol. 70 (2015), 593–620.
Donald, J.N., Sahdra, B.K., Van Zanden, B., Duineveld, J.J., Atkins, P.W.B., Marshall, S.L., Ciarrochi, J., Does your mindfulness benefit others? A systematic review and meta-analysis of the link between mindfulness and prosocial behaviour. Br. J. Psychol. 110 (2019), 101–125, 10.1111/bjop.12338.
Engert, V., Kok, B.E., Papassotiriou, I., Chrousos, G.P., Singer, T., Specific reduction in cortisol stress reactivity after social but not attention-based mental training. Sci. Adv., 3, 2017, e1700495, 10.1126/sciadv.1700495.
Fjell, A.M., Walhovd, K.B., Structural brain changes in aging: courses, causes and cognitive consequences. Rev. Neurosci. 21 (2010), 187–221, 10.1515/revneuro.2010.21.3.187.
Fountain-Zaragoza, S., Prakash, R.S., Mindfulness training for healthy aging: impact on attention, well-being, and inflammation. Front. Aging Neurosci., 9, 2017, 11, 10.3389/fnagi.2017.00011.
Fox, K.C.R., Dixon, M.L., Nijeboer, S., Girn, M., Floman, J.L., Lifshitz, M., Ellamil, M., Sedlmeier, P., Christoff, K., Functional neuroanatomy of meditation: a review and meta-analysis of 78 functional neuroimaging investigations. Neurosci. Biobehav Rev. 65 (2016), 208–228, 10.1016/j.neubiorev.2016.03.021.
Fox, K.C.R., Nijeboer, S., Dixon, M.L., Floman, J.L., Ellamil, M., Rumak, S.P., Sedlmeier, P., Christoff, K., Is meditation associated with altered brain structure? A systematic review and meta-analysis of morphometric neuroimaging in meditation practitioners. Neurosci. Biobehav. Rev. 43 (2014), 48–73, 10.1016/j.neubiorev.2014.03.016.
Fredrickson, B.L., Cohn, M.A., Coffey, K.A., Pek, J., Finkel, S.M., Open hearts build lives: positive emotions, induced through loving-kindness meditation, build consequential personal resources. J. Pers. Soc. Psychol. 95 (2008), 1045–1062, 10.1037/a0013262.
Friedman, E.M., Ruini, C., Foy, C.R., Jaros, L., Love, G., Ryff, C.D., Lighten UP! A community-based group intervention to promote eudaimonic well-being in older adults: a multi-site replication with 6 month follow-up. Clin. Gerontol. 42 (2019), 387–397, 10.1080/07317115.2019.1574944.
Gard, T., Hölzel, B.K., Lazar, S.W., The potential effects of meditation on age-related cognitive decline: a systematic review. Ann. N. Y. Acad. Sci. 1307 (2014), 89–103, 10.1111/nyas.12348.
Garland, E.L., Kiken, L.G., Faurot, K., Palsson, O., Gaylord, S.A., Upward spirals of mindfulness and reappraisal: testing the mindfulness-to-meaning theory with autoregressive latent trajectory modeling. Cogn. Ther. Res. 41 (2017), 381–392, 10.1007/s10608-016-9768-y.
Geiger, P.J., Boggero, I.A., Brake, C.A., Caldera, C.A., Combs, H.L., Peters, J.R., Baer, R.A., Mindfulness-based interventions for older adults: a review of the effects on physical and emotional well-being. Mindfulness 7 (2016), 296–307, 10.1007/s12671-015-0444-1.
Graser, J., Stangier, U., Compassion and loving-kindness meditation: an overview and prospects for the application in clinical samples. Harv. Rev. Psychiatry 26 (2018), 201–215, 10.1097/HRP.0000000000000192.
Innes, K.E., Selfe, T.K., Meditation as a therapeutic intervention for adults at risk for Alzheimerâ€TMs disease – potential benefits and underlying mechanisms. Front. Psychiatry, 5, 2014, 10.3389/fpsyt.2014.00040.
Kaliman, P., Alvarez-López, M.J., Cosín-Tomás, M., Rosenkranz, M.A., Lutz, A., Davidson, R.J., Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators. Psychoneuroendocrinology 40 (2014), 96–107, 10.1016/j.psyneuen.2013.11.004.
Kim, B.J., Cho, I.S., Cho, K.I., Impact of mindfulness based stress reduction therapy on myocardial function and endothelial dysfunction in female patients with microvascular angina. J. Cardiovasc. Ultrasound 25 (2017), 118–123, 10.4250/jcu.2017.25.4.118.
Kivipelto, M., Solomon, A., Ahtiluoto, S., Ngandu, T., Lehtisalo, J., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., Lindström, J., Mangialasche, F., Nissinen, A., Paajanen, T., Pajala, S., Peltonen, M., Rauramaa, R., Stigsdotter-Neely, A., Strandberg, T., Tuomilehto, J., Soininen, H., The finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER): study design and progress. Alzheimer's Dement. 9 (2013), 657–665, 10.1016/j.jalz.2012.09.012.
Klimecki, O.M., Leiberg, S., Lamm, C., Singer, T., Functional neural plasticity and associated changes in positive affect after compassion training. Cereb. Cortex 23 (2013), 1552–1561, 10.1093/cercor/bhs142.
Kral, T.R.A., Schuyler, B.S., Mumford, J.A., Rosenkranz, M.A., Lutz, A., Davidson, R.J., Impact of short- and long-term mindfulness meditation training on amygdala reactivity to emotional stimuli. NeuroImage 181 (2018), 301–313, 10.1016/j.neuroimage.2018.07.013.
Kurth, F., Cherbuin, N., Luders, E., Promising links between meditation and reduced (brain) aging: an attempt to bridge some gaps between the alleged fountain of youth and the youth of the field. Front. Psychol., 8, 2017, 860, 10.3389/fpsyg.2017.00860.
Lenze, E.J., Hickman, S., Hershey, T., Wendleton, L., Ly, K., Dixon, D., Doré, P., Wetherell, J.L., Mindfulness-based stress reduction for older adults with worry symptoms and co-occurring cognitive dysfunction. Int. J. Geriatr. Psychiatry 29 (2014), 991–1000, 10.1002/gps.4086.
Luders, E., Cherbuin, N., Gaser, C., Estimating brain age using high-resolution pattern recognition: younger brains in long-term meditation practitioners. Neuroimage 134 (2016), 508–513, 10.1016/j.neuroimage.2016.04.007.
Lutz, A., Brefczynski-Lewis, J., Johnstone, T., Davidson, R.J., Regulation of the neural circuitry of emotion by compassion meditation: effects of meditative expertise. PLoS One, 3, 2008, e1897, 10.1371/journal.pone.0001897.
Lutz, A., Jha, A.P., Dunne, J.D., Saron, C.D., Investigating the phenomenological matrix of mindfulness-related practices from a neurocognitive perspective. Am. Psychol. 70 (2015), 632–658, 10.1037/a0039585.
Lutz, A., Klimecki, O.M., Collette, F., Poisnel, G., Arenaza-Urquijo, E., Marchant, N.L., De La Sayette, V., Rauchs, G., Salmon, E., Vuilleumier, P., Frison, E., Vivien, D., Chételat, G., Medit-Ageing Research Group, The age-well observational study on expert meditators in the medit-ageing European project. Alzheimers Dement. 4 (2018), 756–764, 10.1016/j.trci.2018.11.002.
Malinowski, P., Shalamanova, L., Meditation and cognitive ageing: the role of mindfulness meditation in building cognitive reserve. J. Cogn. Enhanc. 1 (2017), 96–106, 10.1007/s41465-017-0022-7.
Marchant, et al. The SCD-Well randomized controlled trial: Effects of a mindfulness-based intervention versus health education on mental health in patients with subjective cognitive decline (SCD). Alzheimers Dement (N Y), 2018, 10.1016/j.trci.2018.10.010.
Marchant, N.L., Howard, R.J., Cognitive debt and Alzheimer's disease. J. Alzheimer's Dis., 2021.
Marchant, N.L., Lovland, L.R., Jones, R., Pichet Binette, A., Gonneaud, J., Arenaza-Urquijo, E.M., Chételat, G., Villeneuve, S., PREVENT-AD Research Group, Repetitive negative thinking is associated with amyloid, tau, and cognitive decline. Alzheimers Dement 16 (2020), 1054–1064, 10.1002/alz.12116.
Montero-Odasso, M., Ismail, Z., Livingston, G., One third of dementia cases can be prevented within the next 25 years by tackling risk factors. The case “for” and “against”. Alzheimer's Res. Ther. 12 (2020), 1–5, 10.1186/s13195-020-00646-x.
Moynihan, J.A., Chapman, B.P., Klorman, R., Krasner, M.S., Duberstein, P.R., Brown, K.W., Talbot, N.L., Mindfulness-based stress reduction for older adults: effects on executive function, frontal alpha asymmetry and immune function. Neuropsychobiology 68 (2013), 34–43, 10.1159/000350949.
Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., Lindström, J., Mangialasche, F., Paajanen, T., Pajala, S., Peltonen, M., Rauramaa, R., Stigsdotter-Neely, A., Strandberg, T., Tuomilehto, J., Soininen, H., Kivipelto, M., A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 385 (2015), 2255–2263, 10.1016/S0140-6736(15)60461-5.
Norton, S., Matthews, F.E., Barnes, D.E., Yaffe, K., Brayne, C., Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 13 (2014), 788–794, 10.1016/S1474-4422(14)70136-X.
Poisnel, G., Arenaza-Urquijo, E., Collette, F., Klimecki, O.M., Marchant, N.L., Wirth, M., de La Sayette, V., Rauchs, G., Salmon, E., Vuilleumier, P., Frison, E., Maillard, A., Vivien, D., Lutz, A., Chételat, G., Medit-Ageing Research Group, The age-well randomized controlled trial of the medit-ageing European project: effect of meditation or foreign language training on brain and mental health in older adults. Alzheimers Dement. 4 (2018), 714–723, 10.1016/j.trci.2018.10.011.
Prakash, R., Rastogi, P., Dubey, I., Abhishek, P., Chaudhury, S., Small, B.J., Long-term concentrative meditation and cognitive performance among older adults. Neuropsychol. Dev. Cogn. B Aging Neuropsychol. Cogn. 19 (2012), 479–494, 10.1080/13825585.2011.630932.
Quintana-Hernández, D.J., Miró-Barrachina, M.T., Ibáñez-Fernández, I.J., Pino, A.S., Quintana-Montesdeoca, M.P., Rodríguez-de Vera, B., Morales-Casanova, D., Pérez-Vieitez, M., del, C., Rodríguez-García, J., Bravo-Caraduje, N., Mindfulness in the maintenance of cognitive capacities in Alzheimer's disease: a randomized clinical trial. JAD 50 (2015), 217–232, 10.3233/JAD-143009.
Richard, E., Van den Heuvel, E., Moll van Charante, E.P., Achthoven, L., Vermeulen, M., Bindels, P.J., Van Gool, W.A., Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress. Alzheimer Dis. Assoc. Disord. 23 (2009), 198–204, 10.1097/WAD.0b013e31819783a4.
Ryff, C.D., Heller, A.S., Schaefer, S.M., van Reekum, C., Davidson, R.J., Purposeful engagement, healthy aging, and the brain. Curr. Behav. Neurosci. Rep. 3 (2016), 318–327, 10.1007/s40473-016-0096-z.
Scarmeas, N., Stern, Y., Cognitive reserve and lifestyle. J. Clin. Exp. Neuropsychol. 25 (2003), 625–633, 10.1076/jcen.25.5.625.14576.
Schutte, N.S., Malouff, J.M., A meta-analytic review of the effects of mindfulness meditation on telomerase activity. Psychoneuroendocrinology 42 (2014), 45–48, 10.1016/j.psyneuen.2013.12.017.
Smart, C.M., Segalowitz, S.J., Mulligan, B.P., Koudys, J., Gawryluk, J.R., Mindfulness training for older adults with subjective cognitive decline: results from a pilot randomized controlled trial. JAD 52 (2016), 757–774, 10.3233/JAD-150992.
Tang, Y.-Y., Hölzel, B.K., Posner, M.I., The neuroscience of mindfulness meditation. Nat. Rev. Neurosci. 16 (2015), 213–225, 10.1038/nrn3916.
Teipel, S., Drzezga, A., Grothe, M.J., Barthel, H., Chételat, G., Schuff, N., Skudlarski, P., Cavedo, E., Frisoni, G.B., Hoffmann, W., Thyrian, J.R., Fox, C., Minoshima, S., Sabri, O., Fellgiebel, A., Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection. Lancet Neurol. 14 (2015), 1037–1053, 10.1016/S1474-4422(15)00093-9.
Valk, S.L., Bernhardt, B.C., Trautwein, F.-M., Böckler, A., Kanske, P., Guizard, N., Collins, D.L., Singer, T., Structural plasticity of the social brain: Differential change after socio-affective and cognitive mental training. Sci. Adv., 3, 2017, e1700489, 10.1126/sciadv.1700489.
Victorson, D., Kentor, M., Maletich, C., Lawton, R.C., Kaufman, V.H., Borrero, M., Languido, L., Lewett, K., Pancoe, H., Berkowitz, C., Mindfulness meditation to promote wellness and manage chronic disease: a systematic review and meta-analysis of mindfulness-based randomized controlled trials relevant to lifestyle medicine. Am. J. Lifestyle Med. 9 (2015), 185–211, 10.1177/1559827614537789.
Yegambaram, M., Manivannan, B., Beach, T.G., Halden, R.U., Role of environmental contaminants in the etiology of Alzheimer's disease: a review. Curr. Alzheimer Res. 12 (2015), 116–146, 10.2174/1567205012666150204121719.
Zellner Keller, B., Singh, N.N., Winton, A.S.W., Mindfulness-based cognitive approach for seniors (MBCAS): program development and implementation. Mindfulness 5 (2014), 453–459, 10.1007/s12671-013-0262-2.
Zufferey, V., Donati, A., Popp, J., Meuli, R., Rossier, J., Frackowiak, R., Draganski, B., von Gunten, A., Kherif, F., Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease. Alzheimers Dement. 7 (2017), 107–114, 10.1016/j.dadm.2017.05.002.
