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Article (Scientific journals)
Evaluation of bovine fibrin sealant in the dog.
Bouvy, Bernard; Rosin, E; Frishmeyer, K J et al.
1993In Journal of Investigative Surgery, 6 (3), p. 241-50
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Keywords :
Fibrin Tissue Adhesive; Animals; Aorta, Thoracic/surgery; Blood Vessel Prosthesis; Cattle; Dogs; Evaluation Studies as Topic; Fibrin Tissue Adhesive/immunology; Male; Risk Factors; Virus Diseases/transmission
Abstract :
[en] Fibrin sealant (human fibrinogen-bovine thrombin) is an effective biodegradable hemostatic agent. However, there is a risk of transmission of infectious viral disease. A new bovine fibrinogen-thrombin sealant (BFTS) was tested for tissue and immune responses in intrathoracic aorta graft in dogs. Intrathoracic aorta replacement was performed in three dogs with a porous Dacron graft presealed with BFTS. Dogs were immunized preoperatively with four dermal applications of BFTS at 9-day intervals. Cellular and humoral immunity to BFTS were determined with lymphocyte blastogenesis test and enzyme-lined immunosorbent assay, respectively. Dogs were necropsied 3 weeks after aortic replacement. Histopathological examination showed that all dogs had a mild inflammatory reaction to the BFTS sealed graft, as expected in response to an inert foreign body. Assay of cellular and humoral immunity to BFTS revealed a low lymphocyte response and a moderate immunoglobulin G (Ig G) response, with no evidence of immediate Ig E (type I) or delayed (type IV) hypersensitivity reaction. We conclude that BFTS causes no adverse tissue response or immunologic reaction when used as a hemostatic agent in the dog even after multiple applications of the material.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Bouvy, Bernard  ;  Université de Liège - ULiège > Département d'Enseignement et de Clinique des animaux de Compagnie (DCC) > Chirurgie des animaux de compagnie ; Department of Surgical Sciences, School of Veterinary Medicine, University of
Rosin, E
Frishmeyer, K J
Dubielzig, R R
Schultz, R D
Language :
English
Title :
Evaluation of bovine fibrin sealant in the dog.
Publication date :
1993
Journal title :
Journal of Investigative Surgery
ISSN :
0894-1939
eISSN :
1521-0553
Volume :
6
Issue :
3
Pages :
241-50
Peer reviewed :
Peer reviewed
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since 22 December 2022

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