International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020).
Farmer, Adam D; Strzelczyk, Adam; Finisguerra, Alessandraet al.
2020 • In Frontiers in Human Neuroscience, 14, p. 568051
[en] Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation (tVNS) across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation(VNS) and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice.
Disciplines :
Neurology
Author, co-author :
Farmer, Adam D; Department of Gastroenterology, University Hospitals of North Midlands NHS Trust, Stoke on Trent, United Kingdom
Strzelczyk, Adam; Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, Goethe-University Frankfurt, Frankfurt am Main, Germany
Finisguerra, Alessandra; Scientific Institute, IRCCS E. Medea, Pasian di Prato, Italy
Gourine, Alexander V; Department of Neuroscience, Physiology and Pharmacology, Centre for Cardiovascular and Metabolic Neuroscience, University College London, London, United Kingdom
Gharabaghi, Alireza; Institute for Neuromodulation and Neurotechnology, University Hospital and University of Tuebingen, Tuebingen, Germany
Hasan, Alkomiet; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany ; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Burger, Andreas M; Laboratory for Biological Psychology, Faculty of Psychology and Educational Sciences, University of Leuven, Leuven, Belgium
Jaramillo, Andrés M; Leibniz Institute for Neurobiology, Magdeburg, Germany
Mertens, Ann; Department of Neurology, Institute for Neuroscience, 4Brain, Ghent University Hospital, Gent, Belgium
Majid, Arshad; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom
Verkuil, Bart; Clinical Psychology and the Leiden Institute of Brain and Cognition, Leiden University, Leiden, Netherlands
Badran, Bashar W; Department of Psychiatry, Medical University of South Carolina, Charleston, SC, United States
Ventura-Bort, Carlos; Department of Biological Psychology and Affective Science, Faculty of Human Sciences, University of Potsdam, Potsdam, Germany
Gaul, Charly; Migraine and Headache Clinic Koenigstein, Königstein im Taunus, Germany
Beste, Christian; Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany
Warren, Christopher M; Utah State University, Logan, UT, United States
Quintana, Daniel S; NORMENT, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway ; Department of Psychology, University of Oslo, Oslo, Norway ; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway
Hämmerer, Dorothea; Medical Faculty, Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany ; Institute of Cognitive Neuroscience, University College London, London, United Kingdom ; Center for Behavioral Brain Sciences Magdeburg (CBBS), Otto-von-Guericke University, Magdeburg, Germany
Freri, Elena; Department of Pediatric Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
Frangos, Eleni; Pain and Integrative Neuroscience Branch, National Center for Complementary and Integrative Health, NIH, Bethesda, MD, United States
Tobaldini, Eleonora; Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy ; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Kaniusas, Eugenijus; Institute of Electrodynamics, Microwave and Circuit Engineering, TU Wien, Vienna, Austria ; SzeleSTIM GmbH, Vienna, Austria
Rosenow, Felix; Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, Goethe-University Frankfurt, Frankfurt am Main, Germany
Capone, Fioravante; Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy
Panetsos, Fivos; Faculty of Biology and Faculty of Optics, Complutense University of Madrid and Institute for Health Research, San Carlos Clinical Hospital (IdISSC), Madrid, Spain
Ackland, Gareth L; Translational Medicine and Therapeutics, Barts and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Kaithwas, Gaurav; Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India
O'Leary, Georgia H; Department of Psychiatry, Medical University of South Carolina, Charleston, SC, United States
Genheimer, Hannah; Department of Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Würzburg, Germany
Jacobs, Heidi I L; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States ; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, Netherlands
Van Diest, Ilse; Research Group Health Psychology, Faculty of Psychology and Educational Sciences, University of Leuven, Leuven, Belgium
Schoenen, Jean ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie (CHR)
Redgrave, Jessica; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom
Fang, Jiliang; Functional Imaging Lab, Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Deuchars, Jim; School of Biomedical Science, Faculty of Biological Science, University of Leeds, Leeds, United Kingdom
Széles, Jozsef C; Division for Vascular Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria
Thayer, Julian F; Department of Psychological Science, University of California, Irvine, Irvine, CA, United States
More, Kaushik; Institute for Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany ; Neuromodulatory Networks, Leibniz Institute for Neurobiology, Magdeburg, Germany
Vonck, Kristl; Department of Neurology, Institute for Neuroscience, 4Brain, Ghent University Hospital, Gent, Belgium
Steenbergen, Laura; Clinical and Cognitive Psychology and the Leiden Institute of Brain and Cognition, Leiden University, Leiden, Netherlands
Vianna, Lauro C; NeuroV̇ASQ̇ - Integrative Physiology Laboratory, Faculty of Physical Education, University of Brasilia, Brasilia, Brazil
McTeague, Lisa M; Department of Psychiatry, Medical University of South Carolina, Charleston, SC, United States
Ludwig, Mareike; Department of Anatomy, Faculty of Medicine, Mersin University, Mersin, Turkey
Veldhuizen, Maria G; Mental Health and Wellbeing Research Group, Vrije Universiteit Brussel, Brussels, Belgium
De Couck, Marijke; Faculty of Health Care, University College Odisee, Aalst, Belgium ; Division of Epileptology, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy
Casazza, Marina; Department of Neurosurgery, University of Tübingen, Tübingen, Germany
Keute, Marius; Institute for Neuromodulation and Neurotechnology, University Hospital and University of Tuebingen, Tuebingen, Germany
Bikson, Marom; Department of Biomedical Engineering, City College of New York, New York, NY, United States
Andreatta, Marta; Department of Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Würzburg, Germany ; Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, Netherlands
D'Agostini, Martina; Research Group Health Psychology, Faculty of Psychology and Educational Sciences, University of Leuven, Leuven, Belgium
Weymar, Mathias; Department of Biological Psychology and Affective Science, Faculty of Human Sciences, University of Potsdam, Potsdam, Germany ; Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany
Betts, Matthew; Department of Anatomy, Faculty of Medicine, Mersin University, Mersin, Turkey ; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Magdeburg, Germany ; Center for Behavioral Brain Sciences, Otto-von-Guericke University, Magdeburg, Germany
Prigge, Matthias; Neuromodulatory Networks, Leibniz Institute for Neurobiology, Magdeburg, Germany
Kaess, Michael; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland ; Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany
Roden, Michael; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany ; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany ; German Center for Diabetes Research, Munich, Germany
Thai, Michelle; Department of Psychology, College of Liberal Arts, University of Minnesota, Minneapolis, MN, United States
Schuster, Nathaniel M; Department of Anesthesiology, Center for Pain Medicine, University of California, San Diego Health System, La Jolla, CA, United States
Montano, Nicola; Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy ; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Hansen, Niels; Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany ; Laboratory of Systems Neuroscience and Imaging in Psychiatry (SNIPLab), University of Göttingen, Göttingen, Germany
Kroemer, Nils B; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
Rong, Peijing; Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China
Fischer, Rico; Department of Psychology, University of Greifswald, Greifswald, Germany
Howland, Robert H; Department of Psychiatry, University of Pittsburgh School of Medicine, UPMC Western Psychiatric Hospital, Pittsburgh, PA, United States
Sclocco, Roberta; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States ; Department of Radiology, Logan University, Chesterfield, MO, United States
Sellaro, Roberta; Cognitive Psychology Unit, Institute of Psychology, Leiden University, Leiden, Netherlands ; Leiden Institute for Brain and Cognition, Leiden, Netherlands ; Department of Developmental Psychology and Socialisation, University of Padova, Padova, Italy
Garcia, Ronald G; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States ; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
Bauer, Sebastian; Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, Goethe-University Frankfurt, Frankfurt am Main, Germany
Gancheva, Sofiya; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany ; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany ; Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Stavrakis, Stavros; Faculty of Biological Science, School of Biomedical Science, University of Leeds, Leeds, United Kingdom
Kampusch, Stefan; Institute of Electrodynamics, Microwave and Circuit Engineering, TU Wien, Vienna, Austria ; SzeleSTIM GmbH, Vienna, Austria
Deuchars, Susan A; School of Biomedical Science, Faculty of Biological Science, University of Leeds, Leeds, United Kingdom
Wehner, Sven; Department of Surgery, University Hospital Bonn, Bonn, Germany
Laborde, Sylvain; Department of Performance Psychology, Institute of Psychology, Deutsche Sporthochschule, Köln, Germany
Usichenko, Taras; Department of Anesthesiology, University Medicine Greifswald, Greifswald, Germany ; Department of Anesthesia, McMaster University, Hamilton, ON, Canada
Polak, Thomas; Laboratory of Functional Neurovascular Diagnostics, AG Early Diagnosis of Dementia, Department of Psychiatry, Psychosomatics and Psychotherapy, University Clinic Würzburg, Würzburg, Germany
Zaehle, Tino; Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany
Borges, Uirassu; Department of Performance Psychology, Institute of Psychology, Deutsche Sporthochschule, Köln, Germany ; Department of Social and Health Psychology, Institute of Psychology, Deutsche Sporthochschule, Köln, Germany
Teckentrup, Vanessa; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
Jandackova, Vera K; Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Ostrava, Czechia ; Department of Human Movement Studies, Faculty of Education, University of Ostrava, Ostrava, Czechia
Napadow, Vitaly; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States ; Department of Radiology, Logan University, Chesterfield, MO, United States
Koenig, Julian; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland ; Section for Experimental Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany
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