Association of the matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of coronavirus disease 2019 (COVID-19); implications of contribution for development of neurological symptoms in the COVID-19 patients.
Central nervous system; Coronavirus disease 2019; Genetic polymorphism; Matrix metalloproteinases; Neurological symptoms; Molecular Biology; Genetics; General Medicine
Abstract :
[en] ("[en] BACKGROUND: Seemingly, the Matrix metalloproteinases (MMPs) play a role in the etiopathogenesis of coronavirus disease 2019 (COVID-19). Here in this study, we determined the association of MMP9 rs3918242, MMP3 rs3025058, and MMP2 rs243865 polymorphisms with the risk of COVID-19, especially in those with neurological syndrome (NS).
METHODS: We enrolled 500 patients with COVID-19 and 500 healthy individuals. To genotype the target SNPs, the Real-time allelic discrimination technique was used. To determine serum levels of MMPs, Enzyme-linked immunosorbent assay (ELISA) was exerted.
RESULTS: The MMP9 gene rs3918242 and MMP3 gene rs3025058 SNP were significantly associated with increased COVID-19 risk and susceptibility to COVID-19 with NS. The serum level of MMP-9 and MMP-3 was significantly higher in COVID-19 cases compared with the healthy controls. Serum MMP-9 and MMP-3 levels were also higher in COVID-19 subjects with NS in comparison to the healthy controls. The polymorphisms in MMP genes were not associated with serum level of MMPs.
CONCLUSION: MMP9 and MMP3 gene polymorphisms increases the susceptibility to COVID-19 as well as COVID-19 with neurologic syndrome, but they probably have no role in the regulation of serum MMP-9 and MMP-3 levels.","[en] ","")
Disciplines :
Microbiology Immunology & infectious disease
Author, co-author :
Ramezani, Samaneh; Immunology Research Center, Inflammation and Inflammatory Diseases Division, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
Ezzatifar, Fatemeh; Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran ; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
Hojjatipour, Tahereh; Department of Hematology and Blood Transfusion, Students Research Centre, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran
Hemmatzadeh, Maryam; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Shabgah, Arezoo Gowhari; School of Medicine, Bam University of Medical Sciences, Bam, Iran
Navashenaq, Jamshid Gholizadeh; Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
Aslani, Saeed; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Shomali, Navid; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Arabi, Mohsen; Department of Physiology, Pharmacology and Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
Babaie, Farhad; Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran
Jadidi-Niaragh, Farhad; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Hosseinzadeh, Ramin; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Feizisani, Fahimeh; Student Research Committee, Sarab Faculty of Medical Sciences, Sarab, Iran
Khodayar, Sara; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
Safari, Roghaiyeh ; Université de Liège - ULiège > GIGA > GIGA Cancer - Cellular and Molecular Epigenetics
Mohammadi, Hamed ; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. mohamadi.h86@gmail.com ; Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. mohamadi.h86@gmail.com
Association of the matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of coronavirus disease 2019 (COVID-19); implications of contribution for development of neurological symptoms in the COVID-19 patients.
Publication date :
01 November 2022
Journal title :
Molecular Biology Reports
ISSN :
0301-4851
eISSN :
1573-4978
Publisher :
Springer Science and Business Media B.V., Netherlands
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