Association of the matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of coronavirus disease 2019 (COVID-19); implications of contribution for development of neurological symptoms in the COVID-19 patients.
Central nervous system; Coronavirus disease 2019; Genetic polymorphism; Matrix metalloproteinases; Neurological symptoms; Molecular Biology; Genetics; General Medicine
Abstract :
[en] ("[en] BACKGROUND: Seemingly, the Matrix metalloproteinases (MMPs) play a role in the etiopathogenesis of coronavirus disease 2019 (COVID-19). Here in this study, we determined the association of MMP9 rs3918242, MMP3 rs3025058, and MMP2 rs243865 polymorphisms with the risk of COVID-19, especially in those with neurological syndrome (NS).
METHODS: We enrolled 500 patients with COVID-19 and 500 healthy individuals. To genotype the target SNPs, the Real-time allelic discrimination technique was used. To determine serum levels of MMPs, Enzyme-linked immunosorbent assay (ELISA) was exerted.
RESULTS: The MMP9 gene rs3918242 and MMP3 gene rs3025058 SNP were significantly associated with increased COVID-19 risk and susceptibility to COVID-19 with NS. The serum level of MMP-9 and MMP-3 was significantly higher in COVID-19 cases compared with the healthy controls. Serum MMP-9 and MMP-3 levels were also higher in COVID-19 subjects with NS in comparison to the healthy controls. The polymorphisms in MMP genes were not associated with serum level of MMPs.
CONCLUSION: MMP9 and MMP3 gene polymorphisms increases the susceptibility to COVID-19 as well as COVID-19 with neurologic syndrome, but they probably have no role in the regulation of serum MMP-9 and MMP-3 levels.","[en] ","")
Disciplines :
Microbiology Immunology & infectious disease
Author, co-author :
Ramezani, Samaneh; Immunology Research Center, Inflammation and Inflammatory Diseases Division, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
Ezzatifar, Fatemeh; Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran ; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
Hojjatipour, Tahereh; Department of Hematology and Blood Transfusion, Students Research Centre, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran
Hemmatzadeh, Maryam; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Shabgah, Arezoo Gowhari; School of Medicine, Bam University of Medical Sciences, Bam, Iran
Navashenaq, Jamshid Gholizadeh; Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
Aslani, Saeed; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Shomali, Navid; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Arabi, Mohsen; Department of Physiology, Pharmacology and Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
Babaie, Farhad; Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran
Jadidi-Niaragh, Farhad; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Hosseinzadeh, Ramin; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Feizisani, Fahimeh; Student Research Committee, Sarab Faculty of Medical Sciences, Sarab, Iran
Khodayar, Sara; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
Safari, Roghaiyeh ; Université de Liège - ULiège > GIGA > GIGA Cancer - Cellular and Molecular Epigenetics
Mohammadi, Hamed ; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. mohamadi.h86@gmail.com ; Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. mohamadi.h86@gmail.com
Association of the matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of coronavirus disease 2019 (COVID-19); implications of contribution for development of neurological symptoms in the COVID-19 patients.
Publication date :
01 November 2022
Journal title :
Molecular Biology Reports
ISSN :
0301-4851
eISSN :
1573-4978
Publisher :
Springer Science and Business Media B.V., Netherlands
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Bibliography
Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W et al (2020) A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579(7798):270–273 DOI: 10.1038/s41586-020-2012-7
Turner AJ, Hiscox JA, Hooper NM (2004) ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci 25(6):291–294 DOI: 10.1016/j.tips.2004.04.001
Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C et al (2020) Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 382(23):2268–2270 DOI: 10.1056/NEJMc2008597
Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J et al (2020) A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis 94:55–58 DOI: 10.1016/j.ijid.2020.03.062
Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L et al (2020) Multiorgan and renal tropism of SARS-CoV-2. N Engl J Med 383(6):590–592 DOI: 10.1056/NEJMc2011400
Yoon S-O, Park S-J, Yun C-H, Chung A-S (2003) Roles of matrix metalloproteinases in tumor metastasis and angiogenesis. J Biochem Mol Biol 36(1):128–137
Yong VW, Power C, Forsyth P, Edwards DR (2001) Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci 2(7):502 DOI: 10.1038/35081571
Shi S, Su M, Shen G, Hu Y, Yi F, Zeng Z et al (2021) Matrix metalloproteinase 3 as a valuable marker for patients with COVID-19. J Med Virol 93(1):528–532 DOI: 10.1002/jmv.26235
Desforges M, Le Coupanec A, Stodola JK, Meessen-Pinard M, Talbot PJ (2014) Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis. Virus Res 194:145–158 DOI: 10.1016/j.virusres.2014.09.011
Ye S (2000) Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases. Matrix Biol 19(7):623–629 DOI: 10.1016/S0945-053X(00)00102-5
Kanamori Y, Matsushima M, Minaguchi T, Kobayashi K, Sagae S, Kudo R et al (1999) Correlation between expression of the matrix metalloproteinase-1 gene in ovarian cancers and an insertion/deletion polymorphism in its promoter region. Cancer Res 59(17):4225–4227
dos Reis ST, Pontes J Jr, Villanova FE, de Andrade Borra PM, Antunes AA, Dall’oglio MF et al (2009) Genetic polymorphisms of matrix metalloproteinases: susceptibility and prognostic implications for prostate cancer. J Urol 181(5):2320–2325 DOI: 10.1016/j.juro.2009.01.012
Yong VW, Zabad RK, Agrawal S, DaSilva AG, Metz LM (2007) Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators. J Neurol Sci 259(1–2):79–84 DOI: 10.1016/j.jns.2006.11.021
Hassanzadeh-Makoui R, Razi B, Aslani S, Imani D, Tabaee SS (2020) The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis. BMC Cardiovasc Disord 20(1):232. 10.1186/s12872-020-01510-4 DOI: 10.1186/s12872-020-01510-4
Singh H, Nain S, Krishnaraj A, Lata S, Dhole TN (2019) Genetic variation of matrix metalloproteinase enzyme in HIV-associated neurocognitive disorder. Gene 698:41–49. 10.1016/j.gene.2019.02.057 DOI: 10.1016/j.gene.2019.02.057
Herbster S, Paladino A, de Freitas S, Boccardo E (2018) Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases. Clinics (Sao Paulo, Brazil) 73 (suppl 1):e551s. https://doi.org/10.6061/clinics/2018/e551s
Mohammadhosayni M, Khosrojerdi A, Lorian K, Aslani S, Imani D, Razi B et al (2020) Matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of multiple sclerosis: systematic review and meta-analysis. BMC Neurol 20(1):218. 10.1186/s12883-020-01804-2 DOI: 10.1186/s12883-020-01804-2
Behl T, Kaur G, Sehgal A, Bhardwaj S, Singh S, Buhas C et al (2021) Multifaceted Role of Matrix Metalloproteinases in Neurodegenerative Diseases: Pathophysiological and Therapeutic Perspectives. Int J Mol Sci 22(3). 10.3390/ijms22031413
Han S, Mallampalli RK (2015) The acute respiratory distress syndrome: from mechanism to translation. J Immunol 194(3):855–860 DOI: 10.4049/jimmunol.1402513
Ebrahimi N, Aslani S, Babaie F, Hemmatzadeh M, Hosseinzadeh R, Joneidi Z et al (2020) Recent findings on the Coronavirus disease 2019 (COVID-19); immunopathogenesis and immunotherapeutics. International immunopharmacology:107082
Yamashita CM, Cybulskie C, Milos S, Zuo YY, McCaig LA, Veldhuizen RA (2016) The effect of matrix metalloproteinase-3 deficiency on pulmonary surfactant in a mouse model of acute lung injury. Can J Physiol Pharmacol 94(6):682–685 DOI: 10.1139/cjpp-2015-0377
Nissinen L, Kähäri V-M (2014) Matrix metalloproteinases in inflammation. Biochimica et Biophysica Acta (BBA)-General Subjects. 1840:2571–25808
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S et al (2020) SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell 181(2):271–280e278. 10.1016/j.cell.2020.02.052 DOI: 10.1016/j.cell.2020.02.052
Phillips JM, Gallagher T, Weiss SR (2017) Neurovirulent murine coronavirus JHM. SD uses cellular zinc metalloproteases for virus entry and cell-cell fusion.Journal of virology91 (8)
Fernandes KS, Brum DG, Sandrim VC, Guerreiro CT, Barreira AA, Tanus-Santos JE (2009) Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease. J Neuroimmunol 214(1–2):128–131 DOI: 10.1016/j.jneuroim.2009.07.004
La Russa A, Cittadella R, De Marco EV, Valentino P, Andreoli V, Trecroci F et al (2010) Single nucleotide polymorphism in the MMP-9 gene is associated with susceptibility to develop multiple sclerosis in an Italian case-control study. J Neuroimmunol 225(1–2):175–179 DOI: 10.1016/j.jneuroim.2010.04.016
Zhang B, Henney A, Eriksson P, Hamsten A, Watkins H, Ye S (1999) Genetic variation at the matrix metalloproteinase-9 locus on chromosome 20q12. 2–13.1. Hum Genet 105(5):418–423
Souslova V, Townsend PA, Mann J, van der Loos CM, Motterle A, D’Acquisto F et al (2010) Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFκB. PLoS ONE 5(3):e9902 DOI: 10.1371/journal.pone.0009902
Waubant E (2006) Biomarkers indicative of blood-brain barrier disruption in multiple sclerosis. Dis Markers 22(4):235–244 DOI: 10.1155/2006/709869
Woessner JF Jr (1991) Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5(8):2145–2154 DOI: 10.1096/fasebj.5.8.1850705
Chandler S, Coates R, Gearing A, Lury J, Wells G, Bone E (1995) Matrix metalloproteinases degrade myelin basic protein. Neurosci Lett 201(3):223–226 DOI: 10.1016/0304-3940(95)12173-0
Gijbels K, Proost P, Masure S, Carton H, Billiau A, Opdenakker G (1993) Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein. J Neurosci Res 36(4):432–440 DOI: 10.1002/jnr.490360409
Proost P, Vandamme J, Opdenakker G (1993) Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein. Biochem Biophys Res Commun 192(3):1175–1181 DOI: 10.1006/bbrc.1993.1540
Neumann B, Schmidbauer ML, Dimitriadis K, Otto S, Knier B, Niesen W-D et al (2020) Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms. Journal of the neurological sciences 418
Remsik J, Wilcox JA, Babady NE, McMillen TA, Vachha BA, Halpern NA et al (2021) Inflammatory leptomeningeal cytokines mediate COVID-19 neurologic symptoms in cancer patients. Cancer Cell 39(2):276–283 e273 DOI: 10.1016/j.ccell.2021.01.007
Mohammadhosayni M, Mohammadi FS, Ezzatifar F, Gorabi AM, Khosrojerdi A, Aslani S et al (2021) Matrix metalloproteinases are involved in the development of neurological complications in patients with Coronavirus disease 2019. Int Immunopharmacol 100:108076 DOI: 10.1016/j.intimp.2021.108076
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