Dysmorphism and major anomalies are a main predictor of survival in newborns admitted to the neonatal intensive care unit in the Democratic Republic of Congo.
Manuscript_Dysmorphism and major anomalies are a main predictor of survival in newborns admitted to the neonatal Intensive Care unit in the Democratic Republic of Congo.pdf
NICU; congenital anomalies; newborns; survival; Abnormalities, Multiple/diagnosis; Abnormalities, Multiple/epidemiology; Abnormalities, Multiple/genetics; Democratic Republic of the Congo/epidemiology; Female; Hospitalization; Humans; Infant, Newborn; Infant, Newborn, Diseases/diagnosis; Infant, Newborn, Diseases/epidemiology; Infant, Newborn, Diseases/genetics; Male; Intensive Care Units, Neonatal; Abnormalities, Multiple; Democratic Republic of the Congo; Infant, Newborn, Diseases; Genetics; Genetics (clinical)
Abstract :
[en] In Central-Africa, neonatal infections, asphyxia and prematurity are main reasons for admission to the neonatal intensive care unit and major determinants of newborn survival. Also, the outcome of newborns with congenital anomalies is expected to be poor, due to a lack of state-of-the art care. We conducted a study of 102 newborns recruited in the Neonatal Intensive Care Unit (NICU) at the University Hospitals of Kinshasa, DR Congo, to assess the impact of congenital anomalies. The presence of a major anomaly was associated with a hazard ratio of death of 13.2 (95%CI: 3.7-46.7, p < .001). In addition, the presence of three or more minor anomalies was associated with a 4.5-fold increased risk of death (95%CI: 1.1-18.6, p = .04). We conclude that like major anomalies, the presence of three or more minor anomalies should also be given particular attention and that the evaluation of dysmorphism should be promoted in NICU.
Disciplines :
Genetics & genetic processes Pediatrics
Author, co-author :
Mubungu, Gerrye ; Faculty of Medicine, Center for Human Genetics, University of Kinshasa, Kinshasa, Congo ; Faculty of Medicine, Department of Pediatrics, University of Kinshasa, Kinshasa, Congo ; Center for Human Genetics, University Hospital, University of Leuven, Leuven, Belgium
Makay, Prince; Faculty of Medicine, Center for Human Genetics, University of Kinshasa, Kinshasa, Congo ; Faculty of Medicine, Department of Pediatrics, University of Kinshasa, Kinshasa, Congo
Lumaka Zola, Aimé ; Centre Hospitalier Universitaire de Liège - CHU ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique humaine
Mvuama, Nono; Faculty of Medicine, Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Congo
Tshika, Dahlie; Faculty of Medicine, Center for Human Genetics, University of Kinshasa, Kinshasa, Congo ; Faculty of Medicine, Department of Pediatrics, University of Kinshasa, Kinshasa, Congo
Tady, Bruno-Paul; Faculty of Medicine, Department of Pediatrics, University of Kinshasa, Kinshasa, Congo
Biselele, Thérèse; Faculty of Medicine, Department of Pediatrics, University of Kinshasa, Kinshasa, Congo
Roelants, Mathieu; Department of Public Health and Primary Care, Environment and Health, KU Leuven-University of Leuven, Leuven, Belgium
Tshilobo, Prosper Lukusa; Faculty of Medicine, Center for Human Genetics, University of Kinshasa, Kinshasa, Congo ; Faculty of Medicine, Department of Pediatrics, University of Kinshasa, Kinshasa, Congo ; Center for Human Genetics, University Hospital, University of Leuven, Leuven, Belgium ; Institut National de Recherche Biomédicale, Kinshasa, Kinshasa, Congo
Devriendt, Koenraad; Center for Human Genetics, University Hospital, University of Leuven, Leuven, Belgium
Language :
English
Title :
Dysmorphism and major anomalies are a main predictor of survival in newborns admitted to the neonatal intensive care unit in the Democratic Republic of Congo.
The authors are thankful to children and their parents for their participation to this study, and to the staffs of the Neonatology Intensive Care Unit of the University Hospitals for their great support. The authors are also thankful to Dr Fwanani Patrick, Dr Mbala Bedie for their assistance during data collection. Marc Vervenne Fund Doctoral Scholarship, KU Leuven. Chair for Human Genetics in DR Congo, KU Leuven.
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