adolescent; cancer survivors; child; leukemia, acute lymphoblastic; quality of life; survivorship; young adult; Psychiatry and Mental health; Oncology; Experimental and Cognitive Psychology
Abstract :
[en] ("[en] OBJECTIVE: Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long-term quality of life (QoL) and domains of complaints in these patients. Furthermore, the main priorities of these patients need to be clarified. We assessed long-term QoL outcomes of survivors of childhood ALL compared to matched population controls.
METHODS: QoL data were collected from survivors recruited in France and Belgium between 2012 and 2017, including the Short Form Health Survey (SF-12) and the Quality of Life Systemic Inventory (QLSI). The Wilcoxon test was used to compare SF-12 scale scores between survivors and matched population controls. For the QLSI, comparisons were mainly descriptive.
RESULTS: One hundred and eighty-six survivors (mean age: 27.6 years; range: 18.1-52.8) at follow-up completed QoL measures, amongst whom 180 were matched to controls. Overall, survivors had higher QoL on all SF12 scale scores, indicating that they had better functioning compared to controls. Statistically significant differences on the SF12 were observed for Vitality, Social Functioning, Role Limitations due to Emotional Problems and Mental Health scales. QLSI outcomes suggested that survivors were happier than controls with Couple and Social Relations. Controls were unhappiest compared to survivors with Money, Love life, Self-esteem, Nutrition and Paid Work.
CONCLUSIONS: Our findings suggest that survivors of childhood ALL have better QoL outcomes on some domains compared to the general population, specifically around social and emotional functioning, and that they tend to prioritize their relationships more. Interventions for improving QoL outcomes, might build on existing positive experiences with family, friends and partners.","[en] ","")
Disciplines :
Pediatrics Oncology Public health, health care sciences & services
Author, co-author :
Chantziara, Sofia; School of Health Sciences, University of Southampton, Southampton, UK
Musoro, Jammbe; European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium
Rowsell, Alison C; School of Health Sciences, University of Southampton, Southampton, UK
Sleurs, Charlotte; Department of Oncology, KU Leuven, Leuven, Belgium ; Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands
Coens, Corneel; European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium
Pe, Madeline; European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium
Suciu, Stefan; European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium
Kicinski, Michal; European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium
Missotten, Pierre ; Université de Liège - ULiège > Département de Psychologie > Psychologie de la sénescence et du vieillissement
Vandecruys, Els; Department of Pediatric Hematology-Oncology, Ghent University Hospital, Ghent, Belgium
Uyttebroeck, Anne; Department of Pediatric Hemato-Oncology, University Hospital Leuven, Leuven, Belgium
Dresse, Marie-Françoise ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Pluchart, Claire; Department of Pediatric Haematology and Oncology, CHU Reims, Reims, France
Ferster, Alina; Department of Hemato-Oncology, HUDERF (ULB), Brussels, Belgium
Freycon, Claire; Department of Pediatric Hematology-Oncology, CHU Grenoble, Grenoble, France
Bosch, Jutte Van Der Werff Ten; VUB, Brussels, Belgium
Rohrlich, Pierre; Pediatric Oncology, CHU Nice, Nice, France
Benoit, Yves; Department of Pediatric Hematology-Oncology, Ghent University Hospital, Ghent, Belgium
Darlington, Anne-Sophie; School of Health Sciences, University of Southampton, Southampton, UK
Piette, Caroline ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLG) and Children's Leukemia Group (CLG)
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