[en] For this study, new dendrimers were prepared from poly(propylene imine) (PPI) and polyamidoamine (PAMAM) dendrimers using an efficient acid-base reaction with various phenolic acids. The syntheses were also optimized in both microwave and microfluidic reactors. These ionic and hydrophilic dendrimers were fully characterized and showed excellent antioxidant properties. Their cytotoxic properties have been also determined in the case of fibroblast dermal cells.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bacha, Katia ; Université de Liège - ULiège > TERRA Research Centre ; Molecular Chemistry Reims Institute UMR CNRS 7312, Reims Champagne-Ardenne University, Boîte n° 44, B.P. 1039, 51687 Reims, France
Estager, Julien; Certech, Rue Jules Bordet, 45 Zone Industrielle C, 7180 Seneffe, Belgium
Brassart-Pasco, Sylvie ; UMR CNRS/URCA 7369 (MEDyC), Reims Champagne Ardenne University, 51 Rue Cognacq Jay CS30018, 51095 Reims, France
Chemotti, Catherine ; Université de Liège - ULiège > Département GxABT > Chimie des agro-biosystèmes
Fernandes, Antony E; Certech, Rue Jules Bordet, 45 Zone Industrielle C, 7180 Seneffe, Belgium
Mbakidi, Jean-Pierre; Molecular Chemistry Reims Institute UMR CNRS 7312, Reims Champagne-Ardenne University, Boîte n° 44, B.P. 1039, 51687 Reims, France
Deleu, Magali ; Université de Liège - ULiège > TERRA Research Centre > Chimie des agro-biosystèmes
Bouquillon, Sandrine; Molecular Chemistry Reims Institute UMR CNRS 7312, Reims Champagne-Ardenne University, Boîte n° 44, B.P. 1039, 51687 Reims, France
Language :
English
Title :
Synthesis and Activity of Ionic Antioxidant-Functionalized PAMAMs and PPIs Dendrimers.
This research was co-funded by the European Research Development Fund and Wallonia in the scope of the France-Wallonie-Vlaanderen Interreg 2014–2020 program via the project InTiCosm (project number 1.1.338 INTICOSM).All the authors are grateful to the Interreg France-Wallonie-Vlaanderen 2014–2020 Program (InTiCosm project, ERDF funding) for funding the research and KB PhD thesis. Universities of Reims Champagne-Ardenne (France) and Liège (Belgium) are acknowledged for support. K.B., S.B.-P., J.-P.M. and S.B. are grateful to Grand Est for co-funding the InTiCosm project. A.E.F., J.E., K.B., C.C. and M.D. are grateful to Wallonia for co-funding the InTiCosm project. M.D. thanks the F.R.S.-F.N.R.S. for her position as Senior Research Associate.
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