Article (Scientific journals)
Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial.
Neyrinck, Audrey M; Rodriguez, Julie; Zhang, Zhengxiao et al.
2021In European Journal of Nutrition, 60 (6), p. 3159-3170
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Keywords :
Gut microbiota; Microbial metabolites; Obesity; Prebiotic; Dietary Fiber; Prebiotics; RNA, Ribosomal, 16S; Inulin; Feces; Humans; Inflammation; Retrospective Studies; Medicine (miscellaneous); Nutrition and Dietetics
Abstract :
[en] ("[en] PURPOSE: Inulin-type fructans (ITF) are prebiotic dietary fibre (DF) that may confer beneficial health effects, by interacting with the gut microbiota. We have tested the hypothesis that a dietary intervention promoting inulin intake versus placebo influences fecal microbial-derived metabolites and markers related to gut integrity and inflammation in obese patients. METHODS: Microbiota (16S rRNA sequencing), long- and short-chain fatty acids (LCFA, SCFA), bile acids, zonulin, and calprotectin were analyzed in fecal samples obtained from obese patients included in a randomized, placebo-controlled trial. Participants received either 16 g/d native inulin (prebiotic n = 12) versus maltodextrin (placebo n = 12), coupled to dietary advice to consume inulin-rich versus inulin-poor vegetables for 3 months, in addition to dietary caloric restriction. RESULTS: Both placebo and prebiotic interventions lowered energy and protein intake. A substantial increase in Bifidobacterium was detected after ITF treatment (q = 0.049) supporting our recent data obtained in a larger cohort. Interestingly, fecal calprotectin, a marker of gut inflammation, was reduced upon ITF treatment. Both prebiotic and placebo interventions increased the ratio of tauro-conjugated/free bile acids in feces. Prebiotic treatment did not significantly modify fecal SCFA content but it increased fecal rumenic acid, a conjugated linoleic acid (cis-9, trans-11 CLA) with immunomodulatory properties, that correlated notably to the expansion of Bifidobacterium (p = 0.031; r = 0.052). CONCLUSIONS: Our study demonstrates that ITF-prebiotic intake during 3 months decreases a fecal marker of intestinal inflammation in obese patients. Our data point to a potential contribution of microbial lipid-derived metabolites in gastro-intestinal dysfunction related to obesity. CLINICALTRIALS. GOV IDENTIFIER: NCT03852069 (February 22, 2019 retrospectively, registered).","[en] ","")
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Neyrinck, Audrey M ;  Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, avenue E. Mounier box B1.73.11, B-1200, Brussels, Belgium
Rodriguez, Julie ;  Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, avenue E. Mounier box B1.73.11, B-1200, Brussels, Belgium
Zhang, Zhengxiao ;  Department of Medicine, University of Alberta, Edmonton, Canada
Seethaler, Benjamin ;  Institute of Nutritional Medicine, University of Hohenheim, Hohenheim, Germany
Sánchez, Cándido Robles;  Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, avenue E. Mounier box B1.73.11, B-1200, Brussels, Belgium
Roumain, Martin ;  Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, Brussels, Belgium
Hiel, Sophie;  Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, avenue E. Mounier box B1.73.11, B-1200, Brussels, Belgium
Bindels, Laure B ;  Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, avenue E. Mounier box B1.73.11, B-1200, Brussels, Belgium
Cani, Patrice D ;  Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, avenue E. Mounier box B1.73.11, B-1200, Brussels, Belgium ; WELBIO- Walloon Excellence in Life Sciences and Biotechnology, UCLouvain, Université catholique de Louvain, Brussels, Belgium
Paquot, Nicolas ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de diabétologie, nutrition, maladies métaboliques
Cnop, Miriam;  ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium ; Division of Endocrinology, Erasmus Hospital, Université Libre de Bruxelles, Brussels, Belgium
Nazare, Julie-Anne ;  Rhône-Alpes Research Center for Human Nutrition, Université-Lyon, CarMeN Laboratory, Hospices Civils de Lyon, Lyon, France
Laville, Martine ;  Rhône-Alpes Research Center for Human Nutrition, Université-Lyon, CarMeN Laboratory, Hospices Civils de Lyon, Lyon, France
Muccioli, Giulio G ;  Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, Brussels, Belgium
Bischoff, Stephan C ;  Institute of Nutritional Medicine, University of Hohenheim, Hohenheim, Germany
Walter, Jens ;  Department of Medicine, University of Alberta, Edmonton, Canada ; Department of Medicine, and School of Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland
Thissen, Jean-Paul;  Pole of Endocrinology, Diabetes and Nutrition, Institut de Recherche Expérimentale et Clinique, UCLouvain, Université catholique de Louvain, Brussels, Belgium
Delzenne, Nathalie M ;  Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, avenue E. Mounier box B1.73.11, B-1200, Brussels, Belgium. nathalie.delzenne@uclouvain.be
More authors (8 more) Less
Language :
English
Title :
Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial.
Publication date :
September 2021
Journal title :
European Journal of Nutrition
ISSN :
1436-6207
eISSN :
1436-6215
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
Volume :
60
Issue :
6
Pages :
3159-3170
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Service Publique de Wallonie-Économie, Emploi, Recherche
Funding text :
We are grateful to the study participants for their participation in the study. We thank Coralie Frenay for dietetic analysis. We thank Véronique Allaeys for the excellent technical assistance. We thank the UCLouvain’s platform “Support en méthodologie et calcul statistique” and more specifically Céline Bugli for their advice concerning statistical analyses. We thank Céline Druart and Florence Mailleux for their precious help and implication for the LCFA analysis. CRS is a beneficiary of a postdoctoral fellowship program from Fundación Alfonso Martin Escudero. NMD is a recipient of grants from the Fonds de la Recherche Scientifique (FRS-FNRS, convention PINT-MULTI R.8013.19 (NEURON, call 2019) and convention PDR T.0068.19) and from UCLouvain (Action de Recherche Concertée ARC18-23/092). PDC is supported by the Fonds Baillet Latour (Grant for Medical Research 2015), the Fonds de la Recherche Scientifique (FNRS, FRFS-WELBIO: WELBIO-CR-2019C-02R, and EOS program no.30770923).We are grateful to the study participants for their participation in the study. We thank Coralie Frenay for dietetic analysis. We thank Véronique Allaeys for the excellent technical assistance. We thank the UCLouvain’s platform “Support en méthodologie et calcul statistique” and more specifically Céline Bugli for their advice concerning statistical analyses. We thank Céline Druart and Florence Mailleux for their precious help and implication for the LCFA analysis. CRS is a beneficiary of a postdoctoral fellowship program from Fundación Alfonso Martin Escudero. NMD is a recipient of grants from the Fonds de la Recherche Scientifique (FRS-FNRS, convention PINT-MULTI R.8013.19 (NEURON, call 2019) and convention PDR T.0068.19) and from UCLouvain (Action de Recherche Concertée ARC18-23/092). PDC is supported by the Fonds Baillet Latour (Grant for Medical Research 2015), the Fonds de la Recherche Scientifique (FNRS, FRFS-WELBIO: WELBIO-CR-2019C-02R, and EOS program no.30770923).This study was supported by the Service Public de Wallonie (SPW-EER, convention FiberTAG 1610365 and convention FOOD4GUT 1318148, Belgium).
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