[en] Obesity is associated with an increased risk of several neurological and psychiatric diseases, but few studies report the contribution of biological features in the occurrence of mood disorders in obese patients. The aim of the study is to evaluate the potential links between serum metabolomics and gut microbiome, and mood disturbances in a cohort of obese patients. Psychological, biological characteristics and nutritional habits were evaluated in 94 obese subjects from the Food4Gut study stratified according to their mood score assessed by the Positive and Negative Affect Schedule (PANAS). The fecal gut microbiota and plasma non-targeted metabolomics were analysed. Obese subjects with increased negative mood display elevated levels of Coprococcus as well as decreased levels of Sutterella and Lactobacillus. Serum metabolite profile analysis reveals in these subjects altered levels of several amino acid-derived metabolites, such as an increased level of L-histidine and a decreased in phenylacetylglutamine, linked to altered gut microbiota composition and function rather than to differences in dietary amino acid intake. Regarding clinical profile, we did not observe any differences between both groups. Our results reveal new microbiota-derived metabolites that characterize the alterations of mood in obese subjects, thereby allowing to propose new targets to tackle mood disturbances in this context. Food4gut, clinicaltrial.gov: NCT03852069.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Leyrolle, Quentin; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium
Cserjesi, Renata; Center for Social and Cultural Psychology, Université Libre de Bruxelles, 1000 Brussels, Belgium ; Institute of Psychology, Eötvös Loránd University, 1053 Budapest, Hungary
Demeure, Romane; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium
Neyrinck, Audrey M ; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium
Amadieu, Camille; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium
Rodriguez, Julie; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium
Kärkkäinen, Olli ; School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland
Hanhineva, Kati; Food Chemistry and Food Development Unit, Department of Life Technologies, University of Turku, 20014 Turku, Finland ; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland
Paquot, Nicolas ; Centre Hospitalier Universitaire de Liège - CHU > > Service de diabétologie, nutrition, maladies métaboliques
Cnop, Miriam ; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium ; Division of Endocrinology, Erasmus Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium
Cani, Patrice D ; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium ; WELBIO-Walloon Excellence in Life Sciences and BIOtechnology, UCLouvain, 1200 Brussels, Belgium
Thissen, Jean-Paul; Pole of Endocrinology, Diabetes and Nutrition, Institut de Recherche Expérimentale et Clinique IREC, UCLouvain, 1200 Brussels, Belgium
Bindels, Laure B ; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium
Klein, Olivier ; Center for Social and Cultural Psychology, Université Libre de Bruxelles, 1000 Brussels, Belgium
Luminet, Olivier; Research Institute for Psychological Sciences, UCLouvain, 1348 Louvain-la-Neuve, Belgium
Delzenne, Nathalie M ; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, 1200 Brussels, Belgium
SPW - Service Public de Wallonie [BE] F.R.S.-FNRS - Fund for Scientific Research [BE] FWB - Fédération Wallonie-Bruxelles [BE] Academy of Finland [FI]
Funding text :
Funding: This study was supported by the Service Public de Wallonie (SPW-EER, FOOD4GUT project, convention 1318148) and Fonds de la Recherche Scientifique (FRS)-FNRS (PINT-MULTI R.8013.19 (NEURON, call 2019) and PDR T.0068.19). NMD is a recipient of a grant from the Fédération Wallonie-Bruxelles (Action de Recherche Concertée ARC18-23/092). OL is a Research Director from the FRS-FNRS. PDC is a senior research associate at FRS-FNRS (Fonds de la Recherche Scientifique), Belgium and is supported by the Fonds Baillet Latour (Grant for Medical Research 2015), the Fonds de la Recherche Scientifique (FNRS, FRFS-WELBIO: WELBIO-CR-2019C-02R, and EOS program no.30770923). RC was supported by Bolyai Janos Research Fellowship of the Hungarian Academy of Science. KH was supported by Academy of Finland (Grant no. 321716).Acknowledgments: We thank all the funders who supported this work: ERANET-NEURON; Service Public de Wallonie; Fonds de la Recherche Scientifique; Fédération Wallonie-Bruxelles; Fonds Baillet Latour; Academy of Finland; Hungarian Academy of Science.
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