[en] Bovine Viral Diarrhea Virus (BVDV) is one of the main pathogens that affects ruminants worldwide, generating significant economic losses. Like other RNA viruses, BVDV is characterized by a high genetic variability, generating the emergence of new variants, and increasing the risk of new outbreaks. The last report on BVDV genotypes in France was in 2008, since which there have been no new information. The goal of this study is to determine the genetic diversity of BVDV strains currently circulating in France. To this aim, samples of cattle were taken from different departments that are part of the main areas of livestock production during the years 2018 to 2020. Using the partial sequence of the 5'UTR region of the viral genome, we identified and classified 145 samples corresponding to Pestivirus A and one sample corresponding to Pestivirus D. For the Pestivirus A samples, the 1e, 1b, 1d, and 1l genotypes, previously described in France, were identified. Next, the 1r and 1s genotypes, not previously described in the country, were detected. In addition, a new genotype was identified and was tentatively assigned as 1x genotype. These results indicate an increase in the genetic diversity of BVDV in France.
Disciplines :
Médecine vétérinaire & santé animale
Auteur, co-auteur :
Rivas, José; Fundamental and Applied Research for Animals and Health (FARAH), Faculty of
Hasanaj, Alesia ; Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Pathologie générale et autopsies ; Fundamental and Applied Research for Animals and Health (FARAH), Faculty of
Deblon, Caroline ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) ; Fundamental and Applied Research for Animals and Health (FARAH), Faculty of
Gisbert, Philippe; Ceva Santé Animale, Libourne, France.
Garigliany, Mutien-Marie ; Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Pathologie générale et autopsies ; Fundamental and Applied Research for Animals and Health (FARAH), Faculty of
Langue du document :
Anglais
Titre :
Genetic diversity of Bovine Viral Diarrhea Virus in cattle in France between 2018 and 2020.
Ridpath JF. Bovine Viral Diarrhea Virus: Global Status. Vol. 26, Veterinary Clinics of North America—Food Animal Practice. Amsterdam: Elsevier (2010). p. 105–21. 10.1016/j.cvfa.2009.10.00720117546
Krametter-Froetscher R Duenser M Preyler B Theiner A Benetka V Moestl K et al. Pestivirus infection in sheep and goats in West Austria. Vet J. (2010) 186:342–6. 10.1016/j.tvjl.2009.09.00620042353
Becher P Orlich M Shannon AD Horner G König M Thiel HJ. Phylogenetic analysis of pestiviruses from domestic and wild ruminants. J General Virol. (1997) 78:1357–66. 10.1099/0022-1317-78-6-13579191930
Blome S Beer M Wernike K. New leaves in the growing tree of pestiviruses. Adv Virus Res. (2017) 99:139–60. 10.1016/bs.aivir.2017.07.00329029724
Smith DB Meyers G Bukh J Gould EA Monath T Muerhoff AS et al. Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae. J General Virol. (2017) 98:2106–12. 10.1099/jgv.0.00087328786787
Yeşilbag K Alpay G Becher P. Variability and global distribution of subgenotypes of bovine viral diarrhea virus. Viruses. (2017) 9:128. 10.3390/v906012828587150
Deng M Chen N Guidarini C Xu Z Zhang J Cai L et al. Prevalence and genetic diversity of bovine viral diarrhea virus in dairy herds of China. Vet Microbiol. (2020) 242:108565. 10.1016/j.vetmic.2019.10856532122580
Walker PJ Siddell SG Lefkowitz EJ Mushegian AR Adriaenssens EM Dempsey DM et al. Changes to virus taxonomy and the Statutes ratified by the International Committee on Taxonomy of Viruses (2020). Arch Virol. (2020) 165:2737–48. 10.1007/s00705-020-04752-x32816125
Decaro N. HoBi-like pestivirus and reproductive disorders. Front Vet Sci. (2020). 7:622447. 10.3389/fvets.2020.62244733415134
Giammarioli M Ridpath JF Rossi E Bazzucchi M Casciari C De Mia GM. Genetic detection and characterization of emerging HoBi-like viruses in archival foetal bovine serum batches. Biologicals. (2015) 43:220–4. 10.1016/j.biologicals.2015.05.00926071653
Vilček S Herring AJ Herring JA Nettleton PF Lowings JP Paton DJ. Pestiviruses isolated from pigs, cattle and sheep can be allocated into at least three genogroups using polymerase chain reaction and restriction endonuclease analysis. Arch Virol. (1994) 136:309–23. 10.1007/BF013210608031236
Righi C Petrini S Pierini I Giammarioli M De Mia GM. Global distribution and genetic heterogeneity of border disease virus. Viruses. (2021) 13:950. 10.3390/v1306095034064016
Jackova A Novackova M Pelletier C Audeval C Gueneau E Haffar A et al. The extended genetic diversity of BVDV-1: typing of BVDV isolates from France. Vet Res Commun. (2008) 32:7–11. 10.1007/s11259-007-9012-z17657577
Vilček Š Paton DJ Durkovic B Strojny L Ibata G Moussa A et al. Bovine viral diarrhoea virus genotype 1 can be separated into at least eleven genetic groups. Arch Virol. (2001) 146:99–115. 10.1007/s00705017019411266221
QGIS.org (2022). Available online at: https://www.qgis.org/en/site/ (accessed March 23, 2022).
Kumar S Stecher G Li M Knyaz C Tamura K MEGA X. Molecular evolutionary genetics analysis across computing platforms. Mol Biol Evol. (2018) 35:1547–9. 10.1093/molbev/msy09629722887
Kimura M. (1980). A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol. Evol. 16:111–20. 10.1007/BF017315817463489
FranceAgriMer. Les filières de l'élevage français. Les cahiers de franceagrimer. Montreuil-sous-Bois: Éric Allain (2013). p. 87.
Silveira S Weber MN Mósena ACS da Silva MS Streck AF Pescador CA et al. Genetic diversity of brazilian bovine pestiviruses detected between 1995 and 2014. Transbound Emerg Dis. (2017) 64:613–23. 10.1111/tbed.1242726415862
Spetter MJ Louge Uriarte EL Verna AE Leunda MR Pereyra SB Odeón AC et al. Genomic diversity and phylodynamic of bovine viral diarrhea virus in Argentina. Infect Genet Evol. (2021) 96:105089. 10.1016/j.meegid.2021.10508934563649
Luzzago C Decaro N. Epidemiology of bovine pestiviruses circulating in Italy. Front Vet Sci. (2021) 8:669942. 10.3389/fvets.2021.66994234150891
Stalder H Bachofen C Schweizer M Zanoni R Sauerländer D Peterhans E. Traces of history conserved over 600 years in the geographic distribution of genetic variants of an RNA virus: Bovine viral diarrhea virus in Switzerland. PLoS ONE. (2018) 13:e0207604. 10.1371/journal.pone.020760430517140
Ebranati E Lauzi S Cerutti F Caruso C Masoero L Moreno A et al. Highlighting priority areas for bovine viral diarrhea control in Italy: a phylogeographic approach. Infect Genet Evol. (2018) 58:258–68. 10.1016/j.meegid.2018.01.00629329686
Fulton RW Briggs RE Ridpath JF Saliki JT Confer AW Payton ME et al. Transmission of Bovine viral diarrhea virus 1b to susceptible and vaccinated calves by exposure to persistently infected calves. Can J Vet Res. (2005) 69:161.16187545
Pecora A Malacari DA Ridpath JF Perez Aguirreburualde MS Combessies G Odeón AC et al. First finding of genetic and antigenic diversity in 1b-BVDV isolates from Argentina. Res Vet Sci. (2014) 96:204–12. 10.1016/j.rvsc.2013.11.00424295740
Porto GS Dall Agnol AM Leme RA de Souza TCGD Alfieri AA Alfieri AF. Detection of pestivirus A (bovine viral diarrhea virus 1) in free-living wild boars in Brazil. Braz J Microbiol. (2021) 52:1037–42. 10.1007/s42770-021-00449-833638128
Giammarioli M Ceglie L Rossi E Bazzucchi M Casciari C Petrini S et al. Increased genetic diversity of BVDV-1: recent findings and implications thereof. Virus Genes. (2015) 50:147–51. 10.1007/s11262-014-1132-225349062
Mirosław P Polak M. Increased genetic variation of bovine viral diarrhea virus in dairy cattle in Poland. BMC Vet Res. (2019) 15:1–12. 10.1186/s12917-019-2029-z31382966
Bachofen C Stalder H Braun U Hilbe M Ehrensperger F Peterhans E. Co-existence of genetically and antigenically diverse bovine viral diarrhoea viruses in an endemic situation. Vet Microbiol. (2008) 131:93–102. 10.1016/j.vetmic.2008.02.02318424020
Casaubon J Vogt HR Stalder H Hug C Ryser-Degiorgis MP. Bovine viral diarrhea virus in free-ranging wild ruminants in Switzerland: low prevalence of infection despite regular interactions with domestic livestock. BMC Vet Res. (2012) 8:204. 10.1186/1746-6148-8-20423107231
Tian B Cai D Li W Bu Q Wang M Ye G et al. Identification and genotyping of a new subtype of bovine viral diarrhea virus 1 isolated from cattle with diarrhea. Arch Virol. (2021) 166:1259. 10.1007/s00705-021-04990-733582856
Ridpath JF. Immunology of BVDV vaccines. Biologicals. (2013) 41:14–9. 10.1016/j.biologicals.2012.07.00322883306
Booth RE Thomas CJ El-Attar LM Gunn G Brownlie J. A phylogenetic analysis of Bovine Viral Diarrhoea Virus (BVDV) isolates from six different regions of the UK and links to animal movement data. Vet Res. (2013) 44:43. 10.1186/1297-9716-44-4323783173
Giangaspero M Harasawa R Weber L Belloli A. Genoepidemiological evaluation of Bovine viral diarrhea virus 2 species based on secondary structures in the 5′ untranslated region. J Vet Med Sci. (2008) 70:571–80. 10.1292/jvms.70.57118628597
Luzzago C Lauzi S Ebranati E Giammarioli M Moreno A Cannella V et al. Extended genetic diversity of bovine viral diarrhea virus and frequency of genotypes and subtypes in cattle in Italy between 1995 and 2013. Biomed Res Int. (2014) 2014:147145. 10.1155/2014/14714525045658
Silveira S Cibulski SP Junqueira DM Mósena ACS Weber MN Mayer FQ et al. Phylogenetic and evolutionary analysis of HoBi-like pestivirus: insights into origin and dispersal. Transbound Emerg Dis. (2020) 67:tbed.13520. 10.1111/tbed.1352032073749
Decaro N Lucente MS Mari V Sciarretta R Pinto P Buonavoglia D et al. Hobi-like pestivirus in aborted bovine fetuses. J Clin Microbiol. (2012) 50:509–12. 10.1128/JCM.05887-1122162547
Braun U Hilbe M Peterhans E Schweizer M. Border disease in cattle. Vet J. (2019) 246:12–20. 10.1016/j.tvjl.2019.01.00630902184
Dubois E Russo P Prigent M Thiéry R. Genetic characterization of ovine pestiviruses isolated in France, between 1985 and 2006. Vet Microbiol. (2008) 130:69–79. 10.1016/j.vetmic.2008.01.00218299176
Luzzago C Ebranati E Cabezón O Fernández-Sirera L Lavín S Rosell R et al. Spatial and temporal phylogeny of border disease virus in pyrenean chamois (Rupicapra p. Pyrenaica). PLoS ONE. (2016) 11:e0168232. 10.1371/journal.pone.016823228033381
Martin C Duquesne V Adam G Belleau E Gauthier D Champion JL et al. Pestiviruses infections at the wild and domestic ruminants interface in the French Southern Alps. Vet Microbiol. (2015) 175:341–8. 10.1016/j.vetmic.2014.11.02525532780
Valdazo-González B Álvarez-Martínez M Sandvik T. Genetic and antigenic typing of border disease virus isolates in sheep from the Iberian Peninsula. Vet J. (2007) 174:316–24. 10.1016/j.tvjl.2006.10.00217126573
Paniagua J García-Bocanegra I Arenas-Montes A Berriatua E Espunyes J Carbonero A et al. Absence of circulation of pestivirus between wild and domestic ruminants in southern Spain. Vet Record. (2016) 178:215. 10.1136/vr.10349026864026
Ministère de L'agriculture et de l'alimentation. Publications officielles - Journal officiel - Arrêté du 31 juillet 2019 fixant des mesures de surveillance et de lutte contre la maladie des muqueuses/diarrhée virale bovine (BVD) NOR: AGRG1920523A. J Officiel Républ Franç. (2019). p. 1–3. Available online at: https://www.legifrance.gouv.fr/download/pdf?id=UxVuUK_SInm5dKwr6bbw08eXG16_Zzx4qTH8vEQiEuo= (accessed Jun 24, 2022).
Agence nationale de sécurité sanitaire de l'alimentation de l'environnement et du travail Anses - Index des Médicaments vétérinaires autorisés en France. Available online at: http://www.ircp.anmv.anses.fr/results.aspx (accessed November 22, 2021).
Alpay G Yeşilbag K. Serological relationships among subgroups in bovine viral diarrhea virus genotype 1 (BVDV-1). Vet Microbiol. (2015) 175:1–6. 10.1016/j.vetmic.2014.10.03425487441
Ridpath JF Fulton RW Kirkland PD Neill JD. Prevalence and antigenic differences observed between bovine viral diarrhea virus subgenotypes isolated from cattle in Australia and feedlots in the Southwestern United States. J Vet Diagn Investig. (2010) 22:184–91. 10.1177/10406387100220020320224075
Sozzi E Righi C Boldini M Bazzucchi M Pezzoni G Gradassi M et al. Cross-reactivity antibody response after vaccination with modified live and killed bovine viral diarrhoea virus (BVD) vaccines. Vaccines (Basel). (2020) 8:1–10. 10.3390/vaccines803037432664468
Mosena ACS Falkenberg SM Ma H Casas E Dassanayake RP Booth R et al. Use of multivariate analysis to evaluate antigenic relationships between US BVDV vaccine strains and non-US genetically divergent isolates. J Virol Methods. (2022) 299:114328. 10.1016/j.jviromet.2021.11432834710497
Leyh RD Fulton RW Stegner JE Goodyear MD Witte SB Lucas P et al. Fetal protection in heifers vaccinated with a modified-live virus vaccine containing bovine viral diarrhea virus subtypes 1a and 2a and exposed during gestation to cattle persistently infected with bovine viral diarrhea virus subtype 1b. Am J Vet Res. (2011) 72:367–75. 10.2460/ajvr.72.3.36721355740
Walz PH Riddell KP Newcomer BW Neill JD Falkenberg SM Cortese VS et al. Comparison of reproductive protection against bovine viral diarrhea virus provided by multivalent viral vaccines containing inactivated fractions of bovine viral diarrhea virus 1 and 2. Vaccine. (2018) 36:3853–60. 10.1016/j.vaccine.2018.04.00529699786
Mosena ACS Falkenberg SM Ma H Casas E Dassanayake RP Walz PH et al. Multivariate analysis as a method to evaluate antigenic relationships between BVDV vaccine and field strains. Vaccine. (2020) 38:5764–72. 10.1016/j.vaccine.2020.07.01032690424
Young NJ Thomas CJ Thompson I Collins ME Brownlie J. Immune responses to non-structural protein 3 (NS3) of bovine viral diarrhoea virus (BVDV) in NS3 DNA vaccinated and naturally infected cattle. Prev Vet Med. (2005) 72:115–20. 10.1016/j.prevetmed.2005.08.01316169103
Endsley JJ Ridpath JF Neill JD Sandbulte MR Roth JA. Induction of T lymphocytes specific for bovine viral diarrhea virus in calves with maternal antibody. Viral Immunol. (2004) 17:13–23. 10.1089/08828240432287542115018659
Endsley JJ Roth JA Ridpath J Neill J. Maternal antibody blocks humoral but not T cell responses to BVDV. Biologicals. (2003) 31:123–5. 10.1016/S1045-1056(03)00027-712770543
Sangewar N Waghela SD Yao J Sang H Bray J Mwangi W. Novel potent IFN-γ-inducing CD8 + T cell epitopes conserved among diverse bovine viral diarrhea virus strains. J Immunol. (2021) 206:1709–18. 10.4049/jimmunol.200142433762324
Riitho V Strong R Larska M Graham SP Steinbach F. Bovine pestivirus heterogeneity and its potential impact on vaccination and diagnosis. Viruses. (2020) 12:1134. 10.3390/v1210113433036281
Meyer G Deplanche M Roux D Moulignie M Picard-Hagen N Lyazrhi F et al. Fetal protection against bovine viral diarrhoea type 1 virus infection after one administration of a live-attenuated vaccine. Vet J. (2012) 192:242–5. 10.1016/j.tvjl.2011.05.01121689959
Newcomer BW Chamorro MF Walz PH. Vaccination of cattle against bovine viral diarrhea virus. Vet Microbiol. (2017) 206:78–83. 10.1016/j.vetmic.2017.04.00328400145
Nardelli S Decaro N Belfanti I Lucente MS Giammarioli M Mion M et al. Do modified live virus vaccines against bovine viral diarrhea induce fetal cross-protection against HoBi-like Pestivirus? Vet Microbiol. (2021) 260:109178. 10.1016/j.vetmic.2021.10917834330023
Antos A Miroslaw P Rola J Polak MP. Vaccination failure in eradication and control programs for bovine viral diarrhea infection. Front Vet Sci. (2021) 8:688911. 10.3389/fvets.2021.68891134268349
Klimowicz-Bodys MD Polak MP Płoneczka-Janeczko K Bagnicka E Zbroja D Rypuła K. Lack of fetal protection against bovine viral diarrhea virus in a vaccinated heifer. Viruses. (2022) 14:311. 10.3390/v1402031135215904
Mari V Losurdo M Lucente MS Lorusso E Elia G Martella V et al. Multiplex real-time RT-PCR assay for bovine viral diarrhea virus type 1, type 2 and HoBi-like pestivirus. J Virol Methods. (2016) 229:1–7. 10.1016/j.jviromet.2015.12.003 26709100