Antimalarial Activity of Cryptolepine and some otrher Anhydronium Bases

[en] Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitemia was suppressed by 80% at 50 mg/kg/day.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Wright, C. W.

Phillipson, J. D.

Awe, S. O.

Kirby, G. C.

Warhurst, D. C.

Quetin-Leclercq, J.

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Language :

English

Title :

Antimalarial Activity of Cryptolepine and some otrher Anhydronium Bases

Publication date :

1996

Journal title :

Phytotherapy Research

ISSN :

0951-418X

eISSN :

1099-1573

Publisher :

Wiley, Chichester, United Kingdom

Volume :

Pages :

361-363

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 11 May 2010

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Bibliography

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