Article (Scientific journals)
Antimalarial Activity of Cryptolepine and some otrher Anhydronium Bases
Wright, C. W.; Phillipson, J. D.; Awe, S. O. et al.
1996In Phytotherapy Research, 10, p. 361-363
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Keywords :
alkaloids; anhydronium bases; cryptolepine; Plasmodium sp.; Alstonia sp.; Cryptolepis sanguinolenta; Strychnos sp.
Abstract :
[en] Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitemia was suppressed by 80% at 50 mg/kg/day.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Wright, C. W.
Phillipson, J. D.
Awe, S. O.
Kirby, G. C.
Warhurst, D. C.
Quetin-Leclercq, J.
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Antimalarial Activity of Cryptolepine and some otrher Anhydronium Bases
Publication date :
1996
Journal title :
Phytotherapy Research
ISSN :
0951-418X
eISSN :
1099-1573
Publisher :
Wiley, Chichester, United Kingdom
Volume :
10
Pages :
361-363
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 May 2010

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