Antarctic fungi; DNA barcoding; bioactive compounds; culturomics; extracellular enzymes; plant–fungus interaction; Plant Science; Ecology, Evolution, Behavior and Systematics; Microbiology (medical)
Abstract :
[en] Microorganisms from extreme environments are considered as a new and valuable reservoir of bioactive molecules of biotechnological interest and are also utilized as tools for enhancing tolerance to (a)biotic stresses in crops. In this study, the fungal endophytic community associated with the leaves of the Antarctic angiosperm Colobanthus quitensis was investigated as a new source of bioactive molecules. We isolated 132 fungal strains and taxonomically annotated 26 representative isolates, which mainly belonged to the Basidiomycota division. Selected isolates of Trametes sp., Lenzites sp., Sistotrema sp., and Peniophora sp. displayed broad extracellular enzymatic profiles; fungal extracts from some of them showed dose-dependent antitumor activity and inhibited the formation of amyloid fibrils of α-synuclein and its pathological mutant E46K. Selected fungal isolates were also able to promote secondary root development and fresh weight increase in Arabidopsis and tomato and antagonize the growth of pathogenic fungi harmful to crops. This study emphasizes the ecological and biotechnological relevance of fungi from the Antarctic ecosystem and provides clues to the bioprospecting of Antarctic Basidiomycetes fungi for industrial, agricultural, and medical applications.
Bertini, Laura; Department of Ecological and Biological Sciences, University of Tuscia, Largo dell'Università, 01100 Viterbo, Italy
Perazzolli, Michele ; Centre Agriculture Food Environment (C3A), University of Trento, Via E. Mach 1, 38098 San Michele all'Adige, Italy ; Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38098 San Michele all'Adige, Italy
Proietti, Silvia ; Department of Ecological and Biological Sciences, University of Tuscia, Largo dell'Università, 01100 Viterbo, Italy
Capaldi, Gloria; Department of Ecological and Biological Sciences, University of Tuscia, Largo dell'Università, 01100 Viterbo, Italy
Savatin, Daniel V ; Department of Agriculture and Forest Sciences, University of Tuscia, Via S. Camillo de Lellis, 01100 Viterbo, Italy
Bigini, Valentina ; Department of Agriculture and Forest Sciences, University of Tuscia, Via S. Camillo de Lellis, 01100 Viterbo, Italy
Longa, Claudia Maria Oliveira ; Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38098 San Michele all'Adige, Italy
Basaglia, Marina ; Department of Agronomy Food Natural Resources Animals and Environment, University of Padova, Viale dell'Università 16, Legnaro, 35020 Padova, Italy
Favaro, Lorenzo ; Department of Agronomy Food Natural Resources Animals and Environment, University of Padova, Viale dell'Università 16, Legnaro, 35020 Padova, Italy
Casella, Sergio; Department of Agronomy Food Natural Resources Animals and Environment, University of Padova, Viale dell'Università 16, Legnaro, 35020 Padova, Italy
Fongaro, Benedetta ; Université de Liège - ULiège > Département des sciences de la vie > Centre d'Ingénierie des Protéines (CIP) ; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy
Polverino de Laureto, Patrizia ; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy
Caruso, Carla ; Department of Ecological and Biological Sciences, University of Tuscia, Largo dell'Università, 01100 Viterbo, Italy
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