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Impact of donor age over 70 years in donation after circulatory death liver transplantation: a 15 years of experience
AMICONE, Caroline; Ledoux, Didier; MEURISSE, Nicolas et al.
2022In Transplantation, 106 (8S), p. 73 (LB-O-15
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Keywords :
foie; greffe; transplantation; complication; donneur; NHBD; ischemia
Abstract :
[en] Background: Advanced donor age has been identified as a risk factor in donation after circulatory death (DCD 3) liver transplantation (LT), associated with poor graft function and development of ischemic cholangiopathy. In this study, we evaluated the results after DCD 3 LT using grafts from donors over 70 years compared to younger grafts (<70 years). Methods: We retrospectively analysed outcome after DCD 3 LT (n=228), comparing donors 􏰀70 years (n=53) and <70 years (n=175) from our center between 2003 and 2020. The two age groups were compared in terms of graft and patient survivals at 1, 3 and 5 years, in terms of donor and recipient demographics, transplant conditions and labora- tory values. Results: The overall graft survivals at 1, 3 and 5 years were 88, 75, 70 per cent respectively. Graft survival rates were not significantly diffe- rent at 5 years between the two groups (P = 0,536). No difference was noted in incidence of acute rejection, biliary strictures, hepatic artery thrombosis or retransplantation rates between the two groups. The time of cold ischemia was significatively lower in the older group (mean 235 min; SD 72) than in younger donor (mean 258 min; SD 72) (p=0.012). The posttransplant AST peak was significatively higher in the advanced age donor group than the second group with 2201±2703 U/L vs 1561U/L (SD 2151±2151 U/L), respectively (p= 0.04).Conclusions: Results for DCD LT from 70-yr-old grafts were similar to those from younger donors. Advanced donors should not be discarded for liver donation if other donor risk factors (such as cold ischemia time and graft quality) are limited.
Disciplines :
Anesthesia & intensive care
Gastroenterology & hepatology
Surgery
Author, co-author :
AMICONE, Caroline ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Ledoux, Didier  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs généraux
MEURISSE, Nicolas ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
Honoré, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
Vandermeulen, Morgan ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
DELBOUILLE, Marie-Hélène ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
MONARD, Josée ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
WARMOES, Audrey ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
Warling, Odile ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Lamproye, Anne ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
KABA, Abdourahmane ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
JORIS, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
Delwaide, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive ; Université de Liège - ULiège > Département des sciences cliniques
Detry, Olivier  ;  Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
More authors (4 more) Less
Language :
English
Title :
Impact of donor age over 70 years in donation after circulatory death liver transplantation: a 15 years of experience
Publication date :
August 2022
Event name :
2022 Joint International Congress
Event organizer :
ILTS, ELITA & LICAGE
Event place :
Istanbul, Turkey
Event date :
du 4 au 7 mai 2022
Audience :
International
Journal title :
Transplantation
ISSN :
0041-1337
eISSN :
1534-6080
Publisher :
Lippincott Williams & Wilkins, Maryland, United States - Maryland
Volume :
106
Issue :
8S
Pages :
73 (LB-O-15)
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 September 2022

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