Effects on nicotine administered via a transdermal delivery system on vigilance : a repeated measure study

[en] Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing test 1.3, 3 and 6.3 hrs after patch application, to verify the involvement of the dose of nicotine on the performance. The results confirm and extend the knowledge on the increasing effects of nicotine on vigilance previously found with orally and transdermally administered nicotine. Moreover, results show that such performance was independent of the time of nicotine absorption, which suggests that a relatively low dose of nicotine suffices to activate vigilance processing. Regarding motor performance, no convincing effect of nicotine was observed on reaction time. ((c) 1999 APA/PsycINFO, all rights reserved)

Research Center/Unit :

Centre de Neurosciences Cognitives et Comportementales - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Mancuso, Giovanna

Andrès Bénito, Pilar

Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

Tirelli, Ezio ; Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér.

Language :

English

Title :

Effects on nicotine administered via a transdermal delivery system on vigilance : a repeated measure study

Publication date :

1999

Journal title :

Psychopharmacology

ISSN :

0033-3158

eISSN :

1432-2072

Publisher :

Springer Verlag, Berlin, Germany

Volume :

142

Issue :

Pages :

18-23

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 November 2009

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Bibliography

Benowitz NL, Chan K, Denaro CH, Jacob P (1991) Stable isotope method for studying transdermal drug absorption: the nicotine patch. Clin Pharmacol Ther 50:286-293
Caspary S, Keller-Stanislawski B, Huber T, Merz PG (1991) Pharmacokinetics of nicotine after application of a 30 cm2 nicotine patch under steady-state conditions. Int J Clin Pharmacol Ther Toxicol 29:92-95
Coull JT, Frith CD, Frackowiak RS, Grasby PM (1996) A fronto-parietal network for rapid visual information processing: a PET study of sustained attention and working memory. Neuropsychologia 34:1085-1095
Edwards JA, Wesnes K, Warburton DM, Gale A (1985) Evidence of more rapid stimulus evaluation following cigarette smoking. Addict Behav 10:113-126
Foulds J, Stapleton J, Swettenham J, Bell N, McSorley K, Russell MA (1996) Cognitive performance effects of subcutaneous nicotine in smokers and never-smokers. Psychopharmacology 127:31-38
Ghatan PH, Ingvar M, Eriksson L, Stone-Elander S, Serrander M, Ekberg K, Wahren J (1998) Cerebral effects of nicotine during cognition in smokers and non-smokers. Psychopharmacology 136:179-189
Heishman SJ, Taylor RC, Henningfield JE (1994) Nicotine and smoking: a review of effects on human performance. Exp Clin Psychopharmacol 2:345-395
Hindmarch I, Kerr JS, Sherwood N (1990) Effects of nicotine gum on psychomotor performance in smokers and non-smokers. Psychopharmacology 100:535-541
Jones GMM, Sahakian BJ, Levy R, Warburton DM, Gray JA (1992) Effects of acute subcutaneous nicotine on attention information processing and short-term memory in Alzheimer's disease. Psychopharmacology 108:485-494
Kochhar N, Warburton DM (1990) Puff-by-puff sensory evaluation of a low to middle tar medium nicotine cigarette designed to maintain nicotine delivery to the smoker. Psychopharmacology 102:343-349
Le Houezec J, Halliday R, Benowitz NL, Callaway E, Naylor H, Herzig K (1994) A low dose of subcutaneous nicotine improves information processing in non-smokers. Psychopharmacology 114:628-634
Mulligan SC, Masterson JG, Devane GJ, Kelly JG (1990) Clinical and pharmacokinetic properties of a transdermal nicotine patch. Clin Pharmacol Ther 47:331-337
Parrott AC (1994) Acute pharmacodynamic tolerance to the subjective effects of cigarette smoking. Psychopharmacology 116: 93-97
Parrott AC, Graig D (1992) Cigarette smoking and nicotine gum (02 and 4 mg): Effects upon four visual attention tasks. Neuropsychology 25:34-43
Parrott AC, Winder G (1989) Nicotine chewing gum (2 mg and 4mg) and cigarette smoking: comparative effects upon vigilance and heart rate. Psychopharmacology 97:257-261
Perkins KA, Grobe JE, Epstein LH, Caggiula A, Stiller RL, Jacob RG (1993) Chronic and acute tolerance to subjective effects of nicotine. Pharmacol Biochem Behav 45:375-381
Perkins KA, Grobe JE, Fonte C, Goettler J, Caggiula AR, Reynolds WA, Stiller RL, Scierka A, Jacob RG (1994) Chronic and acute tolerance to subjective, behavioral and cardiovascular effects of nicotine in humans. J Pharmacol Exp Ther 270:628-638
Perkins KA, Grobe JE, Mitchell SL, Goettler J, Caggiula A, Stiller RL, Scierka A (1995) Acute tolerance to nicotine in smokers: lack of dissipation within 2 hours. Psychopharmacology 118:164-170
Porchet HC, Benowitz NL, Sheiner LB (1980) Pharmacodynamic model of tolerance: application to nicotine. J Pharmacol Exp Ther 244:231-236
Posner MI, Petersen SE (1990) The attention system of the human brain. Annu Rev Neurosci 13:25-42
Posner MI, Petersen SE, Fox PT, Raichle ME (1988) Localization of cognitive operations in the human brain. Science 240:1627-1631
Revell AD (1988) Smoking and performance: a puff-by-puff analysis. Psychopharmacology 96:563-565
Rosenberg J, Benowitz NL, Jacob P, Wilson KM (1890) Disposition kinetics and effects of intravenous nicotine. Clin Pharmacol Ther 28:517-522
Russell MAH (1988) Nicotine replacement: the role of blood nicotine levels their rate of change and nicotine tolerance. Proc Clin Biol Res 261:63-94
Russell MAH, Raw M, Jarvis MJ (1980) Clinical use of nicotine chewing-gum. BMJ 280:1599-1602
Sherwood N (1993) Effects of nicotine on human psychomotor performance. Hum Psychopharmacol 8:155-184
Sherwood N, Kerr JS, Hindmarch I (1992) Psychomotor performance in smokers following single and repeated doses of nicotine gum. Psychopharmacology 108:432-436
Warburton DM, Arnall C (1994) Improvements in performance without nicotine withdrawal. Psychopharmacology 115:539-542
Warburton DM, Mancuso G (1998) Evaluation of the information processing and mood effect of a transdermal nicotine patch. Psychopharmacology 135:305-310
Wesnes K, Revell A (1984) The separate and combined effects of scopolamine and nicotine on human information processing. Psychopharmacology 84:5-11
Wesnes K, Warburton DM (1983) Effects of smoking on rapid information processing performance. Neuropsychobiology 9:223-229
Wesnes K, Warburton DM (1984) The effects of cigarettes of varying yield on rapid information processing performance. Psychopharmacology 82:338-342
West RJ, Jarvis MJ (1986) Effects of nicotine on finger tapping rate in non-smokers. Pharmacol Biochem Behav 25:727-731
Williams DG (1980) Effects of cigarette smoking on immediate memory and performance in different kind of smokers. Br J Psychol 71:83-90
Wilson AL, Langley LK, Monley J, Bauer T, Rottunda S, McFalls E, Kovera C, McCarten JR (1995) Nicotine patches in Alzheimer's disease: pilot study on learning, memory, and safety. Pharmacol Biochem Behav 51:509-514
Winer BJ, Brown DR, Michels KM (1991) Statistical principles in experimental design, 3rd edn. MacGraw-Hill, New York