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Social mind representation: Where does it fail in frontotemporal dementia?

Ruby, P.; Schmidt, Christina; Hogge, Michaël et al.

2007 • In Journal of Cognitive Neuroscience, 19 (4), p. 671-683

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https://hdl.handle.net/2268/2946

DOI
10.1162/jocn.2007.19.4.671

PubMed
17381257

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Keywords :

anosognosia; frontal dementia; PET

Abstract :

[en] We aimed at investigating social disability and its cerebral correlates in frontotemporal dementia (FTD). To do so, we contrasted answers of patients with early-stage FTD and of their relatives on personality trait judgment and on behavior prediction in social and emotional situations. Such contrasts were compared to control contrasts calculated with answers of matched controls tested with their relatives. in addition, brain metabolism was measured in patients with positron emission tomography and the [F-18]fluorodeoxyglucose method. Patients turned out to be as accurate as controls in describing their relative's personality, but they failed to predict their relative's behavior in social and emotional circumstances. Concerning the self, patients were impaired both in Current personality assessment and in prediction of their own behavior. Those two self-evaluation measures did not correlate. Only patients' anosognosia for social behavioral disability was found to be related to decreased metabolic activity in the left temporal pole. Such results suggest that anosognosia for social disability in FTD originates in impaired processing of emotional autobiographical information, leading to a self-representation that does not match current behavior. Moreover, we propose that perspective-taking disability participates in anosognosia, preventing patients from correcting their inaccurate self-representation based on their relative's perspective.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Theoretical & cognitive psychology
Neurosciences & behavior

Author, co-author :

Ruby, P.

Schmidt, Christina ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

Hogge, Michaël; Université de Liège - ULiège

D'Argembeau, Arnaud ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive

Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

Salmon, Eric ; Université de Liège - ULiège > Centre de Recherches du Cyclotron > Département des sciences cliniques- Neuroimagerie des troubles de la mémoire et révalid. cogn.

Language :

English

Title :

Social mind representation: Where does it fail in frontotemporal dementia?

Publication date :

April 2007

Journal title :

Journal of Cognitive Neuroscience

ISSN :

0898-929X

eISSN :

1530-8898

Publisher :

M I T Press, Cambridge, United Kingdom

Volume :

19

Issue :

4

Pages :

671-683

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
EC - European Commission

Funding text :

This work was supported by the National Fund for Scientific Research (FNRS), by the University of Liège, by the InterUniversity Attraction Pole P 5/04, by the EC FP6 project DiMI, LSHB-CT-2005-512146, and by the European Community, which granted P. Ruby a Marie Curie Individual fellowship. F. Collette and A. D’Argembeau are FNRS researchers.

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