[en] We aimed at investigating social disability and its cerebral correlates in frontotemporal dementia (FTD). To do so, we contrasted answers of patients with early-stage FTD and of their relatives on personality trait judgment and on behavior prediction in social and emotional situations. Such contrasts were compared to control contrasts calculated with answers of matched controls tested with their relatives. in addition, brain metabolism was measured in patients with positron emission tomography and the [F-18]fluorodeoxyglucose method. Patients turned out to be as accurate as controls in describing their relative's personality, but they failed to predict their relative's behavior in social and emotional circumstances. Concerning the self, patients were impaired both in Current personality assessment and in prediction of their own behavior. Those two self-evaluation measures did not correlate. Only patients' anosognosia for social behavioral disability was found to be related to decreased metabolic activity in the left temporal pole. Such results suggest that anosognosia for social disability in FTD originates in impaired processing of emotional autobiographical information, leading to a self-representation that does not match current behavior. Moreover, we propose that perspective-taking disability participates in anosognosia, preventing patients from correcting their inaccurate self-representation based on their relative's perspective.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Schmidt, Christina ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Hogge, Michaël; Université de Liège - ULiège
D'Argembeau, Arnaud ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Salmon, Eric ; Université de Liège - ULiège > Centre de Recherches du Cyclotron > Département des sciences cliniques- Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Social mind representation: Where does it fail in frontotemporal dementia?
Publication date :
April 2007
Journal title :
Journal of Cognitive Neuroscience
ISSN :
0898-929X
eISSN :
1530-8898
Publisher :
M I T Press, Cambridge, United Kingdom
Volume :
19
Issue :
4
Pages :
671-683
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique EC - European Commission
Funding text :
This work was supported by the National Fund for Scientific Research (FNRS), by the University of Liège, by the InterUniversity Attraction Pole P 5/04, by the EC FP6 project DiMI, LSHB-CT-2005-512146, and by the European Community, which granted P. Ruby a Marie Curie Individual fellowship. F. Collette and A. D’Argembeau are FNRS researchers.
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