Accelerating the end-to-end production of cyclic phosphate monomers with modular flow chemistry

Morodo Martinez, Romain; Riva, Raphaël; van den Akker, Nynke M. S.; Molin, Daniel G. M.; Jérôme, Christine; Monbaliu, Jean-Christophe

doi:10.1039/d2sc02891c

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Accelerating the end-to-end production of cyclic phosphate monomers with modular flow chemistry

Morodo Martinez, Romain; Riva, Raphaël; van den Akker, Nynke M. S. et al.

2022 • In Chemical Science

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/294310

DOI
10.1039/d2sc02891c

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Keywords :

General Chemistry; continuous-flow chemistry; polymer chemistry

Abstract :

[en] A semi-continuous flow platform allows the safer end-to-end production of cyclic phosphate monomers providing an easier access to polyphosphoesters and their applications.

Disciplines :

Chemistry

Author, co-author :

Morodo Martinez, Romain ; Université de Liège - ULiège > Molecular Systems (MolSys)

Riva, Raphaël ; Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de recherches sur les macromolécules (CERM)

van den Akker, Nynke M. S.; Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands

Molin, Daniel G. M. ; Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands

Jérôme, Christine ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie des macromolécules et des matériaux organiques (CERM)

Monbaliu, Jean-Christophe ; Université de Liège - ULiège > Molecular Systems (MolSys)

Language :

English

Title :

Accelerating the end-to-end production of cyclic phosphate monomers with modular flow chemistry

Publication date :

September 2022

Journal title :

Chemical Science

ISSN :

2041-6520

eISSN :

2041-6539

Publisher :

Royal Society of Chemistry (RSC)

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02891C

Name of the research project :

IN FLOW

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
ERDF - European Regional Development Fund [BE]

Funding number :

MIS F453020F

Funding text :

The authors acknowledge Interreg V-A Euregio Meuse-Rhine (EMR) program (IN FLOW) for funding. IN FLOW was granted a € 2.1 M total budget from the European Regional Development Fund (ERDF). With the investment of EU funds in Interreg projects, the European Union directly invests in the economic development, innovation, territorial development, social inclusion and education in the Euregio Meuse-Rhine. The authors also thank the University of Liège and the F.R.S.-FNRS (Incentive grant for scientific research MIS F453020F, JCMM). Dr G. Gauron and A. Vizza (Corning SAS) are acknowledged for the loan of the AFR reactors and the logistic, technical and scientific support for the scalability trials; M. Gagliardi is acknowledged for his experimental support with the cytotoxicity assays; Dr P. Lecomte is acknowledged for his advice. The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.

Available on ORBi :

since 05 September 2022

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