Acrylamide; Fracture; Osteoarthritis initiative; Osteoporosis; Geriatrics and Gerontology; Aging
Abstract :
[en] BACKGROUND: Acrylamide, a component of fried foods, has been associated with several negative health outcomes. However, the relationship between dietary acrylamide and osteoporotic fractures has been explored by a few cross-sectional studies.
AIMS: To investigate if dietary acrylamide is associated with the onset of fractures in North American participants at high risk/having knee osteoarthritis (OA), over 8 years of follow-up.
METHODS: A Cox's regression analysis, adjusted for baseline confounders was run and the data were reported as hazard ratios (HRs) and 95% confidence intervals (CIs). Dietary acrylamide intake was assessed at the baseline using a food frequency questionnaire and categorized in tertiles (T), whilst fractures' history was recorded using self-reported information.
RESULTS: Altogether, 4,436 participants were included. Compared to participants with lower acrylamide intake (T1; < 3,313 μg), those with a higher acrylamide intake (T3; > 10,180 μg) reported a significantly higher risk of any fracture (HR = 1.37; 95% CI 1.12-1.68; p for trend = 0.009), forearm (HR = 1.73; 95% CI 1.09-2.77; p for trend = 0.04), spine (HR = 2.21; 95% CI 1.14-4.31; p for trend = 0.04), and hip fracture (HR = 4.09; 95% CI 1.29-12.96; p for trend = 0.046).
CONCLUSIONS: Our study is the first to report that high dietary acrylamide may be associated with an increased risk of osteoporotic fractures.
Disciplines :
General & internal medicine
Author, co-author :
Veronese, Nicola ; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, via del Vespro, 141, 90127, Palermo, Italy. nicola.veronese@unipa.it
Bolzetta, Francesco; Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria, Dolo-Mirano District, 3 "Serenissima", Dolo, Italy
Cacco, Chiara; University of Padova, Oncology, Padua, Italy
Cester, Alberto; Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria, Dolo-Mirano District, 3 "Serenissima", Dolo, Italy
Smith, Lee; The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, CB1 1PT, UK
Demurtas, Jacopo; Primary Care Department, Azienda USL Toscana Sud Est, Grosseto, Italy
Cooper, Cyrus; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK ; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK
Rizzoli, Renè; Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Caruso, Maria Gabriella; National Institute of Gastroenterology, Research Hospital, IRCCS De Bellis, Castellana Grotte, Bari, Italy
Notarnicola, Maria; National Institute of Gastroenterology, Research Hospital, IRCCS De Bellis, Castellana Grotte, Bari, Italy ; WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium
Reginster, Jean-Yves ; Université de Liège - ULiège > Unité de recherche Santé publique, épidémiologie et économie de la santé (URSAPES)
Maggi, Stefania; Aging Branch, Neuroscience Institute, National Research Council, 35121, Padua, Italy
Barbagallo, Mario; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, via del Vespro, 141, 90127, Palermo, Italy
Trott, Mike; The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, CB1 1PT, UK ; Vision and Eye Research Institute, Faculty of Health and Medical Sciences, Anglia Ruskin University, Cambridge, UK
Dominguez, Ligia J; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, via del Vespro, 141, 90127, Palermo, Italy ; Faculty of Medicine and Surgery, University of Enna "Kore", Enna, Italy
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