Development and characterization of alginate@montmorillonite hybrid microcapsules for encapsulation and controlled release of quercetin: Effect of clay type
[en] In the present study, different organic and hybrid systems for quercetin (Qr) encapsulation were developed, namely Ca-Alginate (Qr-Alg), Ca-Alginate@Na-montmorillonite (Qr-Alg@Na-Mnt), and Ca-Alginate@CPC-montmorillonite (Qr-Alg@CPC-Mnt). Attenuated total reflecting-Fourier-transform infrared (ATR-FTIR) analysis was used to characterize and prove quercetin encapsulation in the developed microcapsules. The encapsulation efficiency (EE) and loading capacity (LC) of quercetin in elaborated biomaterials were determined. Besides, the release kinetics of quercetin molecules from organic and hybrid microcapsules were carefully investigated in two different aqueous mediums; pure distilled water and distilled water containing Tween 20 (1%, w/v). The obtained results show that all developed microcapsules have a good encapsulation efficiency and loading capacity within the range 97.65 ± 0.57–99.47 ± 0.38% for the EE and 19.26 ± 0.46–23.29 ± 0.82 mg/g for the LC. The release rates of Qr from organic microcapsules Qr-Alg, hybrid microcapsules Qr-Alg@Na-Mnt, and Qr-Alg@CPC-Mnt in distilled water containing Tween 20 (1%, w/v) are 52, 49, and 113 times bigger, respectively, than release rate in distilled water. In addition, the kinetics release from hybrid microcapsules was slower in comparison to organic microcapsules. Also, in the case of hybrid microcapsules, the rate of kinetic release of quercetin from Qr-Alg@Na-Mnt was greater than the one from Qr-Alg@CPC-Mnt. This is due to the strong interactions of quercetin molecules with nanoparticle functional groups of cetylpyridinium chloride modified montmorillonite organoclay (CPC-Mnt) compared to sodium montmorillonite (Na-Mnt). The kinetics of Quercetin release from all developed organic and hybrid microcapsules follows the Korsmeyer–Peppas model and is controlled by non-Fickian diffusion.
Disciplines :
Chemistry Food science
Author, co-author :
Essifi, Kamal; Physical Chemistry of Natural Resources and Process Team, Laboratory of Applied Chemistry and Environment (CPSUNAP-LCAE), Department of Chemistry, Faculty of Sciences, Mohammed First University, Oujda, Morocco
Brahmi, Mohamed; Physical Chemistry of Natural Resources and Process Team, Laboratory of Applied Chemistry and Environment (CPSUNAP-LCAE), Department of Chemistry, Faculty of Sciences, Mohammed First University, Oujda, Morocco
Berraaouan, Doha; Physical Chemistry of Natural Resources and Process Team, Laboratory of Applied Chemistry and Environment (CPSUNAP-LCAE), Department of Chemistry, Faculty of Sciences, Mohammed First University, Oujda, Morocco
Amrani, Amina; Physical Chemistry of Natural Resources and Process Team, Laboratory of Applied Chemistry and Environment (CPSUNAP-LCAE), Department of Chemistry, Faculty of Sciences, Mohammed First University, Oujda, Morocco
El Bachiri, Ali; Physical Chemistry of Natural Resources and Process Team, Laboratory of Applied Chemistry and Environment (CPSUNAP-LCAE), Department of Chemistry, Faculty of Sciences, Mohammed First University, Oujda, Morocco
Fauconnier, Marie-Laure ; Université de Liège - ULiège > Département GxABT ; Université de Liège - ULiège > TERRA Research Centre > Chimie des agro-biosystèmes ; Université de Liège - ULiège > Département GxABT > Chimie des agro-biosystèmes
Tahani, Abdesselam; Physical Chemistry of Natural Resources and Process Team, Laboratory of Applied Chemistry and Environment (CPSUNAP-LCAE), Department of Chemistry, Faculty of Sciences, Mohammed First University, Oujda, Morocco
Language :
English
Title :
Development and characterization of alginate@montmorillonite hybrid microcapsules for encapsulation and controlled release of quercetin: Effect of clay type
The authors are sincerely thankful to MESRSFC, CNRST-Morocco, and UMP for their financial support of Project PPR 15-17 and PARA1-2019. The authors are also thankful to Professor Abdelmonaem Talhaoui, Head of the Department of Chemistry, Faculty of Sciences, Mohammed First University, Oujda, Morocco, for managing the Department of analysis.
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