A review emphasizing on utility of heptad repeat sequence as a tool to design pharmacologically safe peptide-based antibiotics.

Vikas, Yadav; Misra, Richa

doi:10.1016/j.biochi.2021.09.001

Article (Scientific journals)

A review emphasizing on utility of heptad repeat sequence as a tool to design pharmacologically safe peptide-based antibiotics.

Vikas, Yadav; Misra, Richa

2021 • In Biochimie, 191, p. 126-139

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/293684

DOI
10.1016/j.biochi.2021.09.001

PubMed
34492334

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Keywords :

Antimicrobial peptides; Cytotoxicity; Haematotoxicity; Heptad repeat sequence; Leucine zipper motif; Phenylalanine zipper motif; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Humans; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/therapeutic use; Antimicrobial Cationic Peptides/chemistry; Antimicrobial Cationic Peptides/therapeutic use; Drug Design; Repetitive Sequences, Amino Acid; Biochemistry; General Medicine

Abstract :

[en] Extensive usage of antibiotics has created an unprecedented scenario of the rapid emergence of many drug-resistant bacteria, which has become an alarming public health concern around the globe. Search for better alternatives that are as efficacious as antibiotics led to the discovery of antimicrobial peptides (AMPs). These small cationic amphiphilic peptides have emerged as a promising option as antimicrobial agents, owing to their multifaceted implications against varied pathogens. Recent years have witnessed tremendous growth in research on AMPs resulting in them being tested in clinical trials of which six got approved for topical application. The relatively less successful outcome has been attributed to the poor cell selectivity shown by most of the naturally occurring AMPs. This drawback needs to be circumvented by identifying strategies to design safe and effective peptides. In the present review, we have emphasized the importance of heptad repeat sequence (leucine and/or phenylalanine zipper motif) as a tool that has shown great promise in remodeling the toxic AMPs to safe antimicrobial agents.

Disciplines :

Biochemistry, biophysics & molecular biology
Pharmacy, pharmacology & toxicology

Author, co-author :

Vikas, Yadav ; Université de Liège - ULiège > GIGA > GIGA Cancer - Cellular and Molecular Epigenetics

Misra, Richa; Department of Zoology, Sri Venkateswara College, University of Delhi, Delhi, India

Language :

English

Title :

A review emphasizing on utility of heptad repeat sequence as a tool to design pharmacologically safe peptide-based antibiotics.

Publication date :

December 2021

Journal title :

Biochimie

ISSN :

0300-9084

eISSN :

1638-6183

Publisher :

Elsevier B.V., France

Volume :

191

Pages :

126-139

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

Central Drug Research Institute
Kungliga Fysiografiska Sällskapet i Lund

Funding text :

The authors would like to acknowledge and appreciate work done on heptad repeat sequence in AMP by Dr. Jimut Kanti Ghosh lab at CSIR-Central Drug Research Institute, Lucknow, India, which served as a motivation to write this review article. Authors would like to apologize for inadvertently missing out on any relevant study related to the role of heptad-repeat sequence due to lack of space. This review article was written in off hours and on weekends. V.Y. would like to acknowledge grants from the Royal Physiographic Society of Lund, Sweden.

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