[en] Extensive usage of antibiotics has created an unprecedented scenario of the rapid emergence of many drug-resistant bacteria, which has become an alarming public health concern around the globe. Search for better alternatives that are as efficacious as antibiotics led to the discovery of antimicrobial peptides (AMPs). These small cationic amphiphilic peptides have emerged as a promising option as antimicrobial agents, owing to their multifaceted implications against varied pathogens. Recent years have witnessed tremendous growth in research on AMPs resulting in them being tested in clinical trials of which six got approved for topical application. The relatively less successful outcome has been attributed to the poor cell selectivity shown by most of the naturally occurring AMPs. This drawback needs to be circumvented by identifying strategies to design safe and effective peptides. In the present review, we have emphasized the importance of heptad repeat sequence (leucine and/or phenylalanine zipper motif) as a tool that has shown great promise in remodeling the toxic AMPs to safe antimicrobial agents.
Vikas, Yadav ; Université de Liège - ULiège > GIGA > GIGA Cancer - Cellular and Molecular Epigenetics
Misra, Richa; Department of Zoology, Sri Venkateswara College, University of Delhi, Delhi, India
Language :
English
Title :
A review emphasizing on utility of heptad repeat sequence as a tool to design pharmacologically safe peptide-based antibiotics.
Publication date :
December 2021
Journal title :
Biochimie
ISSN :
0300-9084
eISSN :
1638-6183
Publisher :
Elsevier B.V., France
Volume :
191
Pages :
126-139
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Central Drug Research Institute Kungliga Fysiografiska Sällskapet i Lund
Funding text :
The authors would like to acknowledge and appreciate work done on heptad repeat sequence in AMP by Dr. Jimut Kanti Ghosh lab at CSIR-Central Drug Research Institute, Lucknow, India, which served as a motivation to write this review article. Authors would like to apologize for inadvertently missing out on any relevant study related to the role of heptad-repeat sequence due to lack of space. This review article was written in off hours and on weekends. V.Y. would like to acknowledge grants from the Royal Physiographic Society of Lund, Sweden.
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