Article (Scientific journals)
Pupil response speed as a marker of cognitive fatigue in early Multiple Sclerosis.
Guillemin, Camille; Hammad, Grégory; Read, John et al.
2022In Multiple Sclerosis and Related Disorders, 65, p. 104001
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Keywords :
Neurology (clinical); Neurology; General Medicine
Abstract :
[en] Context: Cognitive fatigue (CF) is a disabling symptom frequently reported by patients with multiple sclerosis (pwMS). Whether pwMS in the early disease stages present an increased sensitivity to fatigue induction remains debated. Objective measures of CF have been validated neither for clinical nor research purposes. This study aimed at (i) assessing how fatigue induction by manipulation of cognitive load affects subjective fatigue and behavioral performance in newly diagnosed pwMS and matched healthy controls (HC); and (ii) exploring the relevance of eye metrics to describe CF in pwMS. Methods: Nineteen pwMS with disease duration <5 years and 19 matched HC participated to this study. CF was induced with a dual-task in two separate sessions with varying cognitive load (High and Low cognitive load conditions, HCL and LCL). Accuracy, reaction times (RTs), subjective fatigue and sleepiness states were assessed. Bayesian Analyses of Variance for repeated measures (rmANOVA) explored the effects of time, group and load condition on the assessed variables. Eye metrics (number of long blinks, pupil size and pupil response speed: PRS) were obtained during the CF task for a sub-sample (16 pwMS and 15 HC) and analyzed with Generalized Linear Mixed Models (GLMM). Results: Performance (accuracy and RTs) was lower in the HCL condition and accuracy decreased over time (BFsincl > 100) while RTs did not significantly vary. Performance over task and conditions followed the same pattern of evolution across groups (BFsincl <0.08) suggesting that pwMS did not show increased alteration of performance during fatigue induction. Regarding subjective state, both fatigue and sleepiness increased following the task (BFsincl >15), regardless of condition and group (BFsincl <3). CF in pwMS seems to be associated with PRS, as PRS decreased during the task among pwMS only and especially in the HCL condition (all p <.05). A significant Condition*Group interaction was observed regarding long blinks (p <.0001) as well as an expected effect of cognitive load condition on pupil diameter (p <.01). Conclusion: These results suggest that newly diagnosed pwMS and HC behave similarly during fatigue induction, in terms of both performance decrement and accrued fatigue sensation. Eye metric data further reveal a susceptibility to CF in pwMS, which can be objectively measured.
Research center :
GIGA CRC In vivo Imaging-Cognitive Neurosciences - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Guillemin, Camille  ;  Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog) ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Hammad, Grégory  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Read, John  ;  Université de Liège - ULiège > Faculté de Psychologie, Logopédie et Sciences de l'Education > Master sc. psycho., à fin.
Requier, Florence  ;  Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog)
Charonitis, Maëlle  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Delrue, Gaël ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de médecine de l'appareil locomoteur
Vandeleene, Nora  ;  Université de Liège - ULiège > GIGA ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
LOMMERS, Emilie  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Maquet, Pierre  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Collette, Fabienne  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog) > Cognition et Langage
Language :
English
Title :
Pupil response speed as a marker of cognitive fatigue in early Multiple Sclerosis.
Publication date :
June 2022
Journal title :
Multiple Sclerosis and Related Disorders
ISSN :
2211-0348
eISSN :
2211-0356
Publisher :
Elsevier BV
Volume :
65
Pages :
104001
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRB - Fondation Roi Baudouin [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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since 02 August 2022

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