Article (Scientific journals)
Repetitive saliva-based mass screening as a tool for controlling SARS-CoV-2 transmission in nursing homes.
Saegerman, Claude; Donneau, Anne-Françoise; Speybroeck, Niko et al.
2021In Transboundary and Emerging Diseases
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Keywords :
Belgium; COVID-19; RT-qPCR; SARS-CoV-2; nursing home; saliva test; worker; Immunology and Microbiology (all); Veterinary (all); General Veterinary; General Immunology and Microbiology; General Medicine
Abstract :
[en] Nursing home (NH) residents and staff have been severely affected by the COVID-19 pandemic. The aim of this study was to examine the use of weekly saliva RT-qPCR testing for SARS-CoV-2 detection among NH workers as a strategy to control disease transmission within NHs in Belgium. From 16 November to 27 December 2020, a voluntary and anonymous weekly screening was implemented in a cohort of 50,000 workers across 572 NHs in the Walloon region of Belgium to detect asymptomatic cases of SARS-CoV-2 via saliva RT-qPCR testing and using the Diagenode saliva sample collection device. Positive workers were isolated to avoid subsequent infections in residents and other staff. RT-qPCR testing was based on pooled saliva sampling techniques from three workers, followed by individual testing of each positive or inconclusive pool. The majority of NHs (85%) and 55% of their workers participated. Pooling did not affect sensitivity as it only induced a very decrease in sensitivity estimated as 0.33%. Significant decreases in the prevalence (34.4-13.4%) and incidence of NHs with either single (13.8-2%) or multiple positive workers (3.7-0%) were observed over time. In addition, deaths among NH residents and NH worker absences decreased significantly over time. Weekly saliva RT-qPCR testing for SARS-CoV-2 demonstrated large-scale feasibility and efficacy in disrupting the chain of transmission. Implementation of this testing strategy in NHs could also be extended to other settings with the aim to control viral transmission for maintaining essential activities.
Disciplines :
Immunology & infectious disease
Author, co-author :
Saegerman, Claude  ;  Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Santé publique vétérinaire
Donneau, Anne-Françoise  ;  Université de Liège - ULiège > Santé publique : de la Biostatistique à la Promotion de la Santé
Speybroeck, Niko ;  Research Institute of Health and Society, Catholic University of Louvain, Brussels, Belgium
Diep, Anh Nguyet ;  Biostatistics Unit, Liège University, Liège, Belgium
Williams, Alexandria;  P95 Pharmacovigilance and Epidemiology, Leuven, Belgium
Stamatakis, Lambert;  General Delegation COVID-19, Government of the Walloon Region, Namur, Belgium
Coppieters, Wouter ;  Université de Liège - ULiège > Département de gestion vétérinaire des Ressources Animales (DRA) > Génomique animale
Michel, Fabienne  ;  Université de Liège - ULiège > Département d'économie > UER Economie : Economie sociale et systèmes économiques
Breuer, Christophe  ;  Université de Liège - ULiège > Département de géographie
Dandoy, Margaux ;  Université de Liège - ULiège > HEC Liège : UER > UER Opérations : Recherche opérationnelle et gestion de la production
Ek, Olivier ;  Université de Liège - ULiège > GIGA > GIGA I3 - Cellular and Molecular Immunology
Gourzonès, Claire ;  Université de Liège - ULiège > GIGA > GIGA I3 - Cellular and Molecular Immunology
Schyns, Joey ;  Université de Liège - ULiège > GIGA > GIGA I3 - Cellular and Molecular Immunology
Goffin, Emeline ;  Université de Liège - ULiège > GIGA > GIGA I3 - Cellular and Molecular Immunology
Minner, Frédéric ;  Université de Liège - ULiège > GIGA > GIGA I3 - Cellular and Molecular Immunology
Renault, Véronique  ;  Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Santé publique vétérinaire
Gillet, Laurent   ;  Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Santé publique vétérinaire
Bureau, Fabrice   ;  Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > Biochimie et biologie moléculaire
More authors (8 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
Repetitive saliva-based mass screening as a tool for controlling SARS-CoV-2 transmission in nursing homes.
Publication date :
06 August 2021
Journal title :
Transboundary and Emerging Diseases
ISSN :
1865-1674
eISSN :
1865-1682
Publisher :
John Wiley and Sons Inc, Germany
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Gouvernement Wallon
Funding text :
We gratefully acknowledge the Government of Wallonia for their financial support within the framework of a public contract initiated by the Walloon Agency for a Quality Life (AViQ), as well as Liège University for their collaboration in the project. This work would not have been accomplished without the engagement of participating NHs and people involved in the University of Liège Covid‐19 Platform, in particular E. Baudri, W. Berriche, B. Boniver, J. Fonzé, H. Gillet, S. Guilliams, J. Noël, T. Nothomb, M. Pathammavong, J. Patiny, L. Robaye, J. Smeets, D. Tonneau, Z. Truffaut, T. Weigert. Therefore, we thank them for their dedicated time and trust. Raw data used to generate Figure 3 were provided by Sciensano, the Belgian Institute for Health.
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