Article (Scientific journals)
Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial
De Niet, Sophie; Trémège, Mickaël; Coffiner, Monte et al.
2022In Nutrients, 14 (15), p. 3048
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Keywords :
Food Science; Nutrition and Dietetics; Vitamin D; COVID-19
Abstract :
[en] Retrospective studies showed a relationship between vitamin D status and COVID-19 severity and mortality, with an inverse relation between SARS-CoV-2 positivity and circulating calcifediol levels. The objective of this pilot study was to investigate the effect of vitamin D supplementation on the length of hospital stay and clinical improvement in patients with vitamin D deficiency hospitalized with COVID-19. The study was randomized, double blind and placebo controlled. A total of 50 subjects were enrolled and received, in addition to the best available COVID therapy, either vitamin D (25,000 IU per day over 4 consecutive days, followed by 25,000 IU per week up to 6 weeks) or placebo. The length of hospital stay decreased significantly in the vitamin D group compared to the placebo group (4 days vs. 8 days; p = 0.003). At Day 7, a significantly lower percentage of patients were still hospitalized in the vitamin D group compared to the placebo group (19% vs. 54%; p = 0.0161), and none of the patients treated with vitamin D were hospitalized after 21 days compared to 14% of the patients treated with placebo. Vitamin D significantly reduced the duration of supplemental oxygen among the patients who needed it (4 days vs. 7 days in the placebo group; p = 0.012) and significantly improved the clinical recovery of the patients, as assessed by the WHO scale (p = 0.0048). In conclusion, this study demonstrated that the clinical outcome of COVID-19 patients requiring hospitalization was improved by administration of vitamin D.
Disciplines :
Anesthesia & intensive care
Author, co-author :
De Niet, Sophie 
Trémège, Mickaël
Coffiner, Monte
Rousseau, Anne-Françoise  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
CALMES, Doriane ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Frix, Anne-Noëlle ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
GESTER, Fanny ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Delvaux, Muriel ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
DIVE, Anne-Françoise ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
GUGLIELMI, Elora ;  Centre Hospitalier Universitaire de Liège - CHU > > Unité équipe mobile Sart Tilman
Henket, Monique ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Staderoli, Alicia ;  Centre Hospitalier Universitaire de Liège - CHU > > Unité de chirurgie A NDB
Maesen, Didier ;  Centre Hospitalier Universitaire de Liège - CHU > > Service officine et gaz médicaux
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Guiot, Julien  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Cavalier, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chimie clinique
More authors (6 more) Less
Language :
English
Title :
Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial
Publication date :
26 July 2022
Journal title :
Nutrients
ISSN :
2072-6643
Publisher :
MDPI AG
Volume :
14
Issue :
15
Pages :
3048
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 July 2022

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