Article (Scientific journals)
Abdominal Aortic Aneurysm in Heart Transplant Recipients: New Insights from a 30-year Experience at a Single Center.
Tchana-Sato, Vincent; Koch, Jean-Noël; Ancion, Arnaud et al.
2022In Annals of Vascular Surgery
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Keywords :
Surgery; Cardiology and Cardiovascular Medicine; General Medicine
Abstract :
[en] BACKGROUND: Rare autopsy studies have described smaller kidneys as well as urinary tract anomalies in Down syndrome. This observation has never been investigated in vivo and little is known about the possible consequences upon kidney function. Here we wish to confirm whether children with Down syndrome have smaller kidneys and to evaluate their kidney function in vivo. METHODS: This retrospective cohort study enrolled 49 children with Down syndrome, as well as 49 age- and sex-matched controls at the Queen Fabiola Children's University Hospital in Brussels, Belgium. Doppler and kidney ultrasonography, spot urine albumin to creatinine ratio, estimated glomerular filtration rate (eGFR), and anthropometric data were recorded. RESULTS: Kidney size in children with Down syndrome was smaller than age- and sex-matched controls in terms of length (p < 0.001) and volume (p < 0.001). Kidney function based on eGFR was also decreased in Down syndrome compared to historical normal. Twenty-one of the children with Down syndrome (42%) had eGFR < 90 mL/min/1.73 m2, with 5 of these (10%) having an eGFR < 75 mL/min/1.73 m2. In addition, 7 of the children with Down syndrome (14%) had anomalies of the kidney and/or urinary tract that had previously been undiagnosed. CONCLUSIONS: Children with Down syndrome have significantly smaller kidneys than age-matched controls as well as evidence of decreased kidney function. These findings, in addition to well-noted increased kidney and urologic anomalies, highlight the need for universal anatomical and functional assessment of all individuals with Down syndrome. A higher resolution version of the Graphical abstract is available as Supplementary information.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Tchana-Sato, Vincent  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
Koch, Jean-Noël ;  Centre Hospitalier Universitaire de Liège - CHU > > Bloc opératoire chirurgie cardio-vasculaire (+1BC)
Ancion, Arnaud  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique ; CHU Liège - Central University Hospital of Liege [BE] > SIME > Biostatistics
Minga Lowampa, Elie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
Burelli, Mara;  Department of Cardiovascular Surgery, CHU Liege, Liege, Belgium
Defraigne, Jean-Olivier ;  Université de Liège - ULiège > GIGA > GIGA Cardiovascular Sciences - Surgical Research Center
Sakalihasan, Natzi ;  Université de Liège - ULiège > GIGA > GIGA Cardiovascular Sciences - Surgical Research Center
Language :
English
Title :
Abdominal Aortic Aneurysm in Heart Transplant Recipients: New Insights from a 30-year Experience at a Single Center.
Publication date :
24 June 2022
Journal title :
Annals of Vascular Surgery
ISSN :
0890-5096
eISSN :
1615-5947
Publisher :
Elsevier Inc., Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Funding text :
The authors of the manuscript want to thank Dr. Samuel Bruls, as well as all the transplant coordinators for their help in collecting the data on the heart transplant recipients included in the study. We also want to thank Ms. Laurence Seidel for her help with the statistical analysis. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Available on ORBi :
since 26 July 2022

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