Article (Scientific journals)
Eosinophils and Lung Cancer: From Bench to Bedside.
SIBILLE, Anne; CORHAY, Jean-Louis; LOUIS, Renaud et al.
2022In International Journal of Molecular Sciences, 23 (9), p. 5066
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Keywords :
biomarkers; eosinophils; immunotherapy; non-small cell lung cancer; predictive value; prognostic value; Biomarkers; Immune Checkpoint Inhibitors; Eosinophils/pathology; Humans; Immunotherapy; Carcinoma, Non-Small-Cell Lung/pathology; Lung Neoplasms/pathology; Catalysis; Molecular Biology; Spectroscopy; Computer Science Applications; Physical and Theoretical Chemistry; Organic Chemistry; Inorganic Chemistry; General Medicine
Abstract :
[en] Eosinophils are rare, multifunctional granulocytes. Their growth, survival, and tissue migration mainly depend on interleukin (IL)-5 in physiological conditions and on IL-5 and IL-33 in inflammatory conditions. Preclinical evidence supports an immunological role for eosinophils as innate immune cells and as agents of the adaptive immune response. In addition to these data, several reports show a link between the outcomes of patients treated with immune checkpoint inhibitors (ICI) for advanced cancers and blood eosinophilia. In this review, we present, in the context of non-small cell lung cancer (NSCLC), the biological properties of eosinophils and their roles in homeostatic and pathological conditions, with a focus on their pro- and anti-tumorigenic effects. We examine the possible explanations for blood eosinophilia during NSCLC treatment with ICI. In particular, we discuss the value of eosinophils as a potential prognostic and predictive biomarker, highlighting the need for stronger clinical data. Finally, we conclude with perspectives on clinical and translational research topics on this subject.
Disciplines :
Oncology
Author, co-author :
SIBILLE, Anne  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
CORHAY, Jean-Louis ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
LOUIS, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Ninane, Vincent;  Department of Pulmonary Medicine, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium
JERUSALEM, Guy   ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'oncologie médicale
DUYSINX, Bernard  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
 These authors have contributed equally to this work.
Language :
English
Title :
Eosinophils and Lung Cancer: From Bench to Bedside.
Publication date :
03 May 2022
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
MDPI, Switzerland
Volume :
23
Issue :
9
Pages :
5066
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 July 2022

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