Article (Scientific journals)
Uni-ventricular palliation vs. bi-ventricular repair: differential inflammatory response.
Sigler, Matthias; Rouatbi, Hatem; Vazquez-Jimenez, Jaime et al.
2022In Molecular and Cellular Pediatrics, 9 (1), p. 5
Peer reviewed


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Keywords :
Bi-ventricular repair; Inflammatory balance; Interleukin-10; Interleukin-12; Interleukin-6; Pediatric cardiac surgery; Procalcitonin; Total cavo-pulmonary connection; Tumor necrosis factor-α; Pediatrics, Perinatology and Child Health; Cell Biology; Molecular Biology; General Medicine
Abstract :
[en] BACKGROUND: To examine whether uni-ventricular palliation (UVP) and bi-ventricular repair (BVR) result in a different pattern of systemic inflammatory response to pediatric cardiac surgery with extra-corporeal circulation (ECC). METHODS: In 20 children (median age 39.5 months) undergoing either UVP (n = 12) or BVR (n = 8), plasma levels of the inflammatory cytokines TNF-α, IL-6, IL-10, and IL-12 and of procalcitonin (PCT), were measured before, during and after open cardiac surgery up to postoperative day (POD) 10. RESULTS: Epidemiologic, operative- and outcome variables were similar in both groups but post-operative central venous pressure that was higher in UVP. In the whole cohort, the inflammatory response was characterized by an early important, significant and parallel increase of IL-6 and IL-10 that reached their peak values either at the end of ECC (IL-10) or 4 h postoperatively (IL-6), respectively and by a significant and parallel decrease of TNF-α and IL-12 levels after connection to ECC, followed by a bi-phasic significant increase with a first peak 4 h after ECC and a second at POD 10, respectively. Patients after UVP showed a shift of the cytokine balance with lower IL-6- (p = 0.01) after connection to ECC, lower early post-operative TNF-α - (p = 0.02) and IL-12- (p = 0.04) concentrations and lower TNF-α/IL-10-ratio (p = 0.03) as compared with patients with BVR. Levels of PCT were similar in both groups. CONCLUSIONS: UVP is associated with an anti-inflammatory shift of the inflammatory response to cardiac surgery that might be related to the particular hemodynamic situation of patients with UVP.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Sigler, Matthias ;  Pediatric Cardiology, Intensive Care Medicine and Neonatology, Georg-August Universität, Robert-Koch-Str. 40, D-37075, Göttingen, Germany.
Rouatbi, Hatem;  Department of Pediatrics and Pediatric Cardiology, University Hospital Liège, Liège, Belgium
Vazquez-Jimenez, Jaime;  Department of Pediatric Cardiac Surgery, University Hospital Aachen, Aachen, Germany
SEGHAYE, Marie-Christine ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Language :
Title :
Uni-ventricular palliation vs. bi-ventricular repair: differential inflammatory response.
Publication date :
20 March 2022
Journal title :
Molecular and Cellular Pediatrics
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
Volume :
Issue :
Pages :
Peer reviewed :
Peer reviewed
Funders :
Georg-August-Universität Göttingen
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