An oleuropein-based dietary supplement may improve joint functional capacity in older people with high knee joint pain: findings from a multicentre-RCT and post hoc analysis.
function; joint pain; nutritional supplement; oleuropein; Rheumatology; Orthopedics and Sports Medicine
Abstract :
[en] OBJECTIVES: To investigate a 6-month intervention with an olive leaf extract (OLE) on knee functionality and biomarkers of bone/cartilage metabolism and inflammation.
DESIGN: This randomized, double-blind, placebo-controlled, multi-centric trial included 124 subjects with knee pain or mobility issues. Subjects received twice a day one capsule of placebo or 125 mg OLE (Bonolive™, an OLE containing 50 mg of oleuropein) for 6 months. The co-primary endpoints were Knee injury and Osteoarthritis Outcome Score (KOOS) and serum Coll2-1NO2. The secondary endpoints were the subscales of the KOOS, knee pain VAS at rest and at walking, OARSI core set of performance-based tests and multiple inflammatory and bone or cartilage remodeling serum biomarkers and concentration of oleuropein's metabolites in urine.
RESULTS: At 6 months, OLE group was not efficient on global KOOS score, changes of inflammatory and cartilage remodeling biomarkers compared to placebo. Post hoc analyses demonstrated a large and significant treatment effect of OLE in a sub-group of subjects with high walking pain at baseline (p = 0.03). This was observed at 6 months for the global KOOS score, and each different subscale and for pain at walking (p = 0.02). OLE treatment was well tolerated.
CONCLUSION: OLE was not effective on joint discomfort excepted in a sub-group of subjects with high pain at treatment initiation. As oleuropein is well tolerated, OLE can be used to relieve knee joint pain and enhance mobility in subjects with articular pain.
Disciplines :
Rheumatology
Author, co-author :
Horcajada, Marie-Noëlle; Musculoskeletal Health Department, Nestle Research, EPFL Innovation Park, 1015 Lausanne, Switzerland
Jandrain, Bernard; Clinical Pharmacology Unit, ATC S.A., Liège, Belgium
Grek, Vincent ; Université de Liège - ULiège > Centres attachés à la Faculté (Sciences) > Centre Wallon de biologie industrielle ; 2B Clinic, Wavre, Belgium
MALAISE, Michel ; Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
Henrotin, Yves ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)
An oleuropein-based dietary supplement may improve joint functional capacity in older people with high knee joint pain: findings from a multicentre-RCT and post hoc analysis.
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: All the operational phase of this study (patient recruitment, data collection, and statistical analysis) was funded by Société des produits Nestlé SA.
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