Modalités et impact de la cryopréservation des greffons allogéniques en contexte pandémique : recommandations de la Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Allogreffe de cellules souches hématopoïétiques; Cryopréservation; Pandémie COVID-19
Abstract :
[fr] La pandémie COVID-19 a bouleversé les activités de greffe et a nécessité le recours à la cryopréservation des greffons de cellules souches hématopoïétiques allogéniques pour sécuriser la procédure, tant au niveau du patient que du donneur. La cryopréservation en situation allogénique, habituellement anecdotique, a été utilisée par tous les centres francophones. Les données collectées auprès de 24 centres ont été analysées afin d'évaluer l'impact de la cryopréservation sur la qualité du greffon. Cette analyse démontre le rôle délétère du transit prolongé (plus de 48 heures) sur la récupération des progéniteurs CD34+, l'importance de l'augmentation de la dose de progéniteurs CD34+ demandée, justifiant la nécessité d'un contrôle de qualité après décongélation. [en] Method and impact of allografts cryopreservation during the Covid-19 pandemic:
guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular
Therapy (SFGM-TC)
The COVID-19 pandemic disorganized the allogeneic stem cell transplantation activities all over
the world, with the necessity to cryopreserve allografts to secure the procedure for both the
recipient and the donor. Cryopreservation, usually anecdotal, has been used by all the French
speaking centers; data collected from 24 centers were assessed in order to determine the impact
of cryopreservation on the quality of allografts. Our analysis clearly demonstrates that increasing
transit time (more than 48 hours) is deleterious for CD34+ recovery, legitimates the slight increase
of the requested CD34+ cell dose with respect to the average recovery rate as well as the
importance of the quality control on the infused product.
Disciplines :
Hematology
Author, co-author :
Forcade, Edouard; CHU de Bordeaux > Service d'hématologie clinique et thérapie cellulaire
Bacquet, Solenn; CHU Amiens Sud > Unité de thérapie cellulaire
Ballot, Caroline; EFS Hauts-de-France Normandie site de Lille > Laboratoire de thérapie cellulaire
Capin, Lucille; CHU de la Réunion Site Sud > Banque de cellules et tissus
GARNIER, Federico; Agence de la biomédecine > Direction prélèvement et greffe de CSH
Giraud, Christine; CHU de Poitiers > Laboratoire de thérapie cellulaire EFS NVAQ site de Poitiers
Guérout-Vérité, Marie-Agnès; EFS Bretagne site de Rennes > Unité de thérapie cellulaire
Letellier, Catherine; EFS Nouvelle Aquitaine site de Bordeaux > Service ingénierie tissulaire et cellulaire
MAGNANI, Alessandra; Hôpital universitaire Necker-Enfants malades [FR] > Laboratoire de thérapie cellulaire et génique
MAMEZ, Anne-Claire; HUG - Hôpitaux Universitaires de Genève [CH] > Service d'hématologie
NASONE, Justine; Hôpital Saint-Louis [FR] > Unité de thérapie cellulaire
Sinayoko, Mahamadou; Agence de la biomédecine > Direction prélèvement et greffe de CSH
BAUDOUX, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > > Thérapie cellulaire
MIALOU, Valérie; Hôpital Edouard Herriot [FR] > Banque de tissus et cellules
Yakoub-Agha, Ibrahim; ULille - Université de Lille [FR] > Inserm INFINITE U1286,
Calmels, Boris; Institut Paoli Calmettes > Centre de thérapie cellulaire > Module biothérapies du centre d'investigation clinique CBT-1409, Inserm
Modalités et impact de la cryopréservation des greffons allogéniques en contexte pandémique : recommandations de la Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Fisher, V., Khuu, H., David-OCampo, V., Byrne, K., Pavletic, S., Bishop, M., et al. Analysis of the recovery of cryopreserved and thawed CD34 + and CD3 + cells collected for hematopoietic transplantation. Transfusion 54:4 (2014), 1088–1092.
Medd, P., Nagra, S., Hollyman, D., Craddock, C., Malladi, R., Cryopreservation of allogeneic PBSC from related and unrelated donors is associated with delayed platelet engraftment but has no impact on survival. Bone Marrow Transplant 48:2 (2013), 243–248.
Lioznov, M., Dellbrugger, C., Sputtek, A., Fehse, B., Kroger, N., Zander, A.R., Transportation and cryopreservation may impair haematopoietic stem cell function and engraftment of allogeneic PBSCs, but not BM. Bone Marrow Transplant 42:2 (2008), 121–128.
Eapen, M., Zhang, M.J., Tang, X.Y., Lee, S.J., Fei, M.W., Wang, H.L., et al. Hematopoietic cell transplantation with cryopreserved grafts for severe aplastic anemia. Biol Blood Marrow Transplant 26:7 (2020), E161–E166.
Tipton, R., Yakoub-Agha, I., [How we harmonize HSCT clinical practices among the SFGM-TC centers]. Bull Cancer 103:11S (2016), S193–S197.
Kanda, Y., Inoue, M., Uchida, N., Onishi, Y., Kamata, R., Kotaki, M., et al. Cryopreservation of unrelated hematopoietic stem cells from a blood and marrow donor bank during the COVID-19 pandemic: a nationwide survey by the japan marrow donor program. Transplant Cell Ther, 27(8), 2021 [664.e1-e6].
Mfarrej, B., Lemarié, C., Granata, A., Pagliardini, T., Malenfant, C., Lignée, P., et al. Related versus unrelated allogeneic HPC graft cryopreservation: a single-center experience in the context of the global COVID-19 pandemic. Bone Marrow Transplant 56:8 (2021), 2013–2015.
Fernandez-Sojo, J., Azqueta, C., Valdivia, E., Martorell, L., Medina-Boronat, L., Martínez-Llonch, N., et al. Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?. Bone Marrow Transplant 56:10 (2021), 2489–2496.
Valentini, C.G., Chiusolo, P., Bianchi, M., Metafuni, E., Orlando, N., Giammarco, S., et al. Coronavirus disease 2019 pandemic and allogeneic hematopoietic stem cell transplantation: a single center reappraisal. Cytotherapy 23:7 (2021), 635–640.
Wiercinska, E., Schlipfenbacher, V., Bug, G., Bader, P., Verbeek, M., Seifried, E., et al. Allogeneic transplant procurement in the times of COVID-19: Quality report from the central European cryopreservation site. J Transl Med, 19(1), 2021, 145.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
