Article (Scientific journals)
Polymer-based or Polymer-free Stents in Patients at High Bleeding Risk.
Windecker, Stephan; Latib, Azeem; Kedhi, Elvin et al.
2020In New England Journal of Medicine, 382 (13), p. 1208-1218
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Keywords :
Immunosuppressive Agents; Platelet Aggregation Inhibitors; Polymers; H4GXR80IZE (zotarolimus); U36PGF65JH (umirolimus); W36ZG6FT64 (Sirolimus); Coronary Artery Disease/therapy; Coronary Thrombosis/etiology/mortality; Drug Therapy, Combination; Drug-Eluting Stents/adverse effects; Heart Diseases/mortality; Hemorrhage/chemically induced; Humans; Immunosuppressive Agents/administration & dosage; Kaplan-Meier Estimate; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors/adverse effects/therapeutic use; Prosthesis Design; Single-Blind Method; Sirolimus/administration & dosage/analogs & derivatives
Abstract :
[en] BACKGROUND: Polymer-free drug-coated stents provide superior clinical outcomes to bare-metal stents in patients at high bleeding risk who undergo percutaneous coronary intervention (PCI) and are treated with 1 month of dual antiplatelet therapy. Data on the use of polymer-based drug-eluting stents, as compared with polymer-free drug-coated stents, in such patients are limited. METHODS: In an international, randomized, single-blind trial, we compared polymer-based zotarolimus-eluting stents with polymer-free umirolimus-coated stents in patients at high bleeding risk. After PCI, patients were treated with 1 month of dual antiplatelet therapy, followed by single antiplatelet therapy. The primary outcome was a safety composite of death from cardiac causes, myocardial infarction, or stent thrombosis at 1 year. The principal secondary outcome was target-lesion failure, an effectiveness composite of death from cardiac causes, target-vessel myocardial infarction, or clinically indicated target-lesion revascularization. Both outcomes were powered for noninferiority. RESULTS: A total of 1996 patients at high bleeding risk were randomly assigned in a 1:1 ratio to receive zotarolimus-eluting stents (1003 patients) or polymer-free drug-coated stents (993 patients). At 1 year, the primary outcome was observed in 169 of 988 patients (17.1%) in the zotarolimus-eluting stent group and in 164 of 969 (16.9%) in the polymer-free drug-coated stent group (risk difference, 0.2 percentage points; upper boundary of the one-sided 97.5% confidence interval [CI], 3.5; noninferiority margin, 4.1; P = 0.01 for noninferiority). The principal secondary outcome was observed in 174 patients (17.6%) in the zotarolimus-eluting stent group and in 169 (17.4%) in the polymer-free drug-coated stent group (risk difference, 0.2 percentage points; upper boundary of the one-sided 97.5% CI, 3.5; noninferiority margin, 4.4; P = 0.007 for noninferiority). CONCLUSIONS: Among patients at high bleeding risk who received 1 month of dual antiplatelet therapy after PCI, use of polymer-based zotarolimus-eluting stents was noninferior to use of polymer-free drug-coated stents with regard to safety and effectiveness composite outcomes. (Funded by Medtronic; ONYX ONE ClinicalTrials.gov number, NCT03344653.).
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Windecker, Stephan;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Latib, Azeem;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Kedhi, Elvin;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Kirtane, Ajay J;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Kandzari, David E;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Mehran, Roxana;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Price, Matthew J;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Abizaid, Alexandre;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Simon, Daniel I;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Worthley, Stephen G;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Zaman, Azfar;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Hudec, Martin;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Poliacikova, Petra;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Abdul Ghapar, A Kahar Bin;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Selvaraj, Kamaraj;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Petrov, Ivo;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Mylotte, Darren;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Pinar, Eduardo;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Moreno, Raul;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Fabbiocchi, Franco;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Pasupati, Sanjeevan;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Kim, Hyo-Soo;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Aminian, Adel;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Tie, Charles;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Wlodarczak, Adrian;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Hur, Seung-Ho;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Marx, Steven O;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Jankovic, Ivana;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Brar, Sandeep;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Bousquette, Lisa;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Liu, Minglei;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Stone, Gregg W;  From Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
ONYX ONE, Investigators
More authors (23 more) Less
Other collaborator :
Friedrich, Guy
Basic, Daniel
Brenner, Christoph
Dichtl, Wolfgang
Doerler, Jakob
Kirchmair, Rudolf
Klug, Gert
Mair, Johannes
Metzler, Bernhard
Moes, Nico
Plank, Fabian
Schreinlechner, Michael
Stuhlinger, Markus
Zaruba, Marc
Mayerl, Christina
Mrakovic, Anita
Mrakovic, Sarah
Petrov, Ivo
Dimitrova, Viktoria
Dobrev, Georgi
Pavlova, Silvia
Polomski, Petar
Stanillov, Plamen
Stankov, Zoran
Tasheva, Iveta
Kireva, Nadezhda
Milanova, Nadia
Petkova, Dafinka
Stancheva, Nadezhda
Zheglova, Ralitsa
Tie, Charles
Chacko, Georgy
Montarello, Joseph
Sage, Peter
Samaraie, Luay
Sidharta, Samuel
Cole, Joanna
Contibas, Michael
Deans, Renae
Fragnito, Kristen
Thring, Kate
Park, Seung Jung
Ahn, JungMin
Kang, DoYoon
Kwon, Osung
Lee, Pil Hyoung
Lee, Seung Whan
Park, Duk Woo
Jang, Soon Deok
Kim, Jong Sun
Lee, Jung Hwa
Lee, Min Suk
Webster, Mark
Ruygrok, Peter
Somaratne, Jithendra
Stewart, James
Burd, Jan
Clarke, Robin
Fish, Mandy
Conradie, Andre
Di Fiore, David
Grout, David
Wittmer, Hermann
Bryant, Lesley
Fox, Karen
Howes, Kassandra
Morgan, Jill
Nelson, Sonia
Starmer, Gregory
Brazzale, Anthony
Lam, Willis Chunwai
Ng, Kevin
Preston, Shane
Reddy, Saireddy Ramakrishna
Sutcliffe, Steven
Dixon, Sue
Gosley, Michelle
Anderson, Richard
Amtra, Rito
Choudhury, Anirban
Gallagher, Sean
Khurana, Ayush
Chandler, Kayleigh
Hodges, Elizabeth
Holder, Jacqueline
Nott, Claire
Thompson, Elizabeth
Moccetti, Tiziano
Araco, Marco
Bomio, Fulvio
Crljenica, Carmela
Del Bufalo, Alessandro
Moccetti, Marco
Monti, Cristina
Pasotti, Elena
Pedrazzini, Giovanni
Quagliana, Angelo
Rossi, Mariagrazia
Petrova Slater, Iveta
Surder, Daniel
Camporini, Cristina
Chiumiento, Lorena
Forlenza, Rossella
Maspoli, Simona
Polledri, Simona
Ponti, Giada
Serra, Anna
Fabbiocchi, Franco
Bartorelli, Antonio
Calligaris, Giuseppe
De Martini, Stefano
Galli, Stefano
Montorsi, Piero
Teruzzi, Giovanni
Trabattoni, Daniela
Jeong, Myung-Ho
Kim, Min Chul
Kim, Yong Cheol
Kim, Doo Sun Sim Yuri
Aminian, Adel
Ben Yedder, Mohamed
Dolatabadi, Dariouch
Lalmand, Jacques
Lefebvre, Pascal
Conde Y Bolado, Asuncion
El Houri, Aya
Piamonte, Veronica
Teixeira, Elisabete
LANCELLOTTI, Patrizio  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie
DAVIN, Laurent ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie
Gach, Olivier
LEMPEREUR, Mathieu ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie
MARECHAL, Patrick ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie
Christophe, Christophe
Martinez, Martinez
Dive, Anne-Francoise
Doneux, Pierre
Silvestri, Marc
Maillard, Luc
Tavildari, Alain
Sevilla, José
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Clugston, Richard
Erickson, Matthew
Judkins, Chris
Kuppusamy, Harveen
Lee, Felicity
Mabote, Thato
Nguyen, Michael
Rankin, James
Shiekh, Imran Amin
Whelan, Alan
Yong, Gerald
Forrest, Nicole
Greenwell, Della
Tulloch, Gill
Sinhal, Ajay
Chew, Derek
Chuang, Ming-Yu
Nazir, Sheraz
Tee, Su Ling
Tiver, Kathryn
Hincks, Christine
Horsfall, Matthew
Thomas, Simeoni
Wollaston, Fiona
Mylotte, Darren
Ahmed, Khalid
Amario Bel, Xavier
Reddy Bijjam, Venu
Connolly, Niall
Crowley, Jim
Cusack, Ronan
Hynes, Brian
Ullah Jan, Zia
Keane, Stephen
MacNeill, Briain
McGrath, Brian
Nash, Patrick
Neylon, Antoinette
O'Connor, Tim
Quinn, Sandra
Rosseel, Liesbeth
Sharif, Faisal
Burke, Maura
Coen, Eileen
Duane, Linda
Finnerty, Sara
Glynn, Nicola
Ryan, Chloe
Kastberg, Robert
Hellsten, Lasse
Johansson, Staffan
Lutter, Kris
Saleh, Elena
Bergström, Kristina
Mauritzon, Marina
Oldroyd, Keith
Good, Richard
Kelly, Joanne
McLaren, Ruth
O'Donnell, Anna
Tewkesbury, Alex
Teyhan, Fiona
Wojakowski, Wojciech
Dworowy, Sebastian
Gasior, Pawel
Kurzelowski, Radosław
Nowak, Adrianna
Ochała, Andrzej
Haag, Den
Somi, Samer
Bax, Matthijs
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Karijodikoro-Bogaards, Ellen
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Chevalier, Bernard
Ben-Amer, Hakim
Champagne, Stéphane
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Hovasse, Thomas
Lefevre, Thierry
Sanguineti, Francesca
Unterseeh, Thierry
Carado, Julia
Martin Culet, Noëlie
Roger, Séverine
Cruz, Ignacio
Diego, Alejandro
Herrero, Jesús
Martín, Javier
Rodríguez, Javier
Moralejo, Ana
Sanchez Pablo, Clara
Sánchez, Nuria
Pinar, Eduardo
Duran, Juan M
Garcia de Lars, Juan
Gimeno, Juan R
Hurtado, Jose
Lacunza, Javier
Leithold, Gunnar
Lova, Alejandro
Valdesuso, Raul
Valles, Dolores
Vaquerizo, Beatriz
Millan, Raul
Rodriquez Costoya, Iris
Salvatella, Neus
Tizon Marcos, Helena
Cabero, Paula
Ivern, Consol
Sánchez Carpintero, Andrea
Soler, Cristina
Mainar, Vincente
Bordes, Pascual
Pineda, Javier
Ruiz Nodar, Juan Miguel
Valencia, José
Ajo, Maria
Ajo, Raquel
Unikas, Ramūnas
Braukylienė, Rima
Jaruševičius, Gediminas
Morkūnaitė, Kristina
Nemeikša, Sigitas
Pažereckaitė, Daiva
Bin Abdul Ghapar, Abdul Kahar
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Bin Abdullah Ramaiah, Asri Ranga
Selvaraj, Kamaraj
Sivasubramaniam, Vanessa
Tay, Lip Kai
Binti Abdul Haq, Hafsah Begum
Binti Daud, Siti Rohaya
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Cequier, Ángel
Ferreiro, José Luís
Fuentes, Lara
Antoni Gómez, Joan
Gómez Lara, Josep
Gracida, Montserrat
León, Valentina
Romaguera, Rafael
Roura, Gerard
Teruel, Luis
Cañavate, Olga
Guerrero, Sonia
Rodríguez, Silvia
Bosa Ojeda, Francisco
Leiva, Miguel
Méndez Vargas, Corabel
Sánchez-Grande Flecha, Alejandro
Yanes Bowden, Geoffrey
de la Fuente Perdomo, Mária Belén
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Sánchez Recalde, Angel
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Mediavilla, Guiomar
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de la Torre Hernandez, Jose María
Garcia Camarero, Tamara
Hwang, Dae-Hyun Lee
Sainz Laso, Fermin
Veiga Fernandez, Gabriela
Windecker, Stephan
Billinger, Michael
Häner, Jonas
Pilgrim, Thomas
Praz, Fabien
Raeber, Lorenz
Siontis, Georgios
Spirito, Alessandro
Stortecky, Stefan
Valgimiglo, Marco
Bertschy, Magali
Fahrni, Therese
Morf, Laura
Sager, Ursina
Lumpur, Kuala
Malaysia, Malaysia
Bin Nuruddin, Amin Ariff
Arshad, Akmal Hakim
Bin Rosman, Azhari
Bin Wan Rahimi Shah, Faizal
Kolanthaivelu, Jayakhanthan
Penwala, Tanveer Iqbal
Teoh, Chee Kiang
Win, Nay Thu
Syamsi, Renobastian Nur
Selamat, Salizah
Kedhi, Elvin
Berta, Balazs
Gosselink, Antonius
Hermanides, Rik
Kaplan, Eliza
Ottervanger, Jan Paul
Roolvink, Vincent
van Leeuwen, Maarten
Yokota, S
Bouwhuis, Ilse
Rietdijk, Gijsbert Johan Adriaan
Schrijver, Claudia
van den Brink, Linda
van der Laan, Marielle
Henareh, Loghman
Desta, Liyew
Hassan, Shams
Jurga, Juliane
Mogensen, Brynjolfur
Venetsanos, Dimitros
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Kim, Hyung-Seop
Kim, In Cheol
Lee, Cheol Hyun
Nam, Chang-Wook
Park, Hyoung Seob
Yoon, Hyuck Joon
Kwon, So Young
Park, So Hyeon
Toth, Gabor
Buschmann, Eva
Luha, Olev
Schmidt, Albrecht
Zweiker, Robert
Flasch, Marlies
Gharibeh, Sarah
Praschk, Andreas
van 't Hof, Arnoud
Feld, Rob
Gho, Ben
Ilhan, Mustafa
Kietselaer, Bas
Rasoul, Saman
Ruiters, Alexander
Stein, Mèra
Theunissen, Ralph
Vainer, Jindrich
Veenstra, Leo
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Kasperski, Ilse
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Mahadevan, Kalaivani
Austin, Rosalynn
Howe, Serena
Scott, Kerrie
Suttling, Anne
Turner, Charlotte
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Lee, Michael Kang-Yin
Chan, Alan Ka Chun
Chan, Kam Tim
Cheng, Yuet Wong
Chui, Shing Fung
Fu, Chiu Lai
Kwok, Kevin Chun Kit
Luk, Ngai Hong
Wong, Eric Chi Yuen
Chan, Cecilia
Leung, Jo Ka-Wai
Liew, Houng Bang
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Chow, Kwok Kang
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Salleh, Siti Nur Syuhada
Sekaran, Vithiyah
Sevalingam, Raj Kumar
Bin Syaripuddin, Alfieyanto
Tan, You Zhuan
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Pungging, Normalah
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Chan, Kelvin Ki Wan
Chan, Will Yap Hang
Fang, Jonathan
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Chan, Alice
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Lisnovs, Artjoms
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Puchalski, Robert J
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Singh, Suhasini
Sowden, Nicholas
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Tomlinson, Stephen
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Sharp, Andrew
Renouf, Adrian
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Godbeer, Emma
Keenan, Samantha
Mackle, Daisy
Kalra, Sundeep
Manmathan, Gavin
Badhan, Gurpreet Rani
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Henriksen, Peter
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Bhindi, Ravinay
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Whitbourn, Robert
Adams, Heath
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Sulehan, Juriah Binti
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Chae, In-Ho
Cho, Young-Seok
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Yun, Ji Yeon
Kim, Hyo Soo
Cho, Hyun-Jai
Han, Jung Kyu
Kang, Hyun-Jae
Kang, Jee Hoon
Koo, Bon Kwon
Park, Kyung-Woo
Yang, Hanmo
Jeong, Jae-Hoon
Lee, Jin Hwa
Chang, Kiyuk
Hwang, Byung Hee
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Lee, Jae Hyun
Jang, Yangsoo
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Choi, Dong-Hoon
Hong, Myeong-Ki
Hong, Sung Jin
Kim, Byeong-Keuk
Kim, Joong Sun
Ko, Young-Guk
Cho, Yusun
Kim, So Young
Kim, Woo Sin
Tresukosol, Damras
Towashiraporn, Korakoth
Wongpraparut, Nattawut
Chaiphet, Olaree
Reanthong, Treenet
Witt, Nils
Alström, Patrik
Fedchenko, Nikolai
Jensen, Ulf
Santos Pardo, Irene
Ahlinder, Carolin
Blomberg, Elin
Korsell, Annette
Malkki, Katri
Österblom, Ulrika
Sundelin, Runa
Jan Suttorp, Maarten
Agostoni, Pierfrancesco
Arslan, Fatih
Arnoud, Mike
Bosschaert, Ramon
Eefting, Frank
Rensing, Bernard
Ten Berg, Jurriën
van den Akker, Bertinel
van Kuijk, Jan-Peter
Albersen, Inke
Gornelda Bras, Rebecca
Feirabend, Conny
Helwig-Vernooij, Johanna Catharina
Kranen, Gerda
Nakamura, Rosana
Oostveen, Manfred
Larsen, Alf Inge
Bogale, Nigussie
Bonarjee, Vernon
Ogne, Christer
Moen, Solfrid
Nilsen, Jorunn
Skadberg, Mette
Sletteboe, Inger Marie
Hudec, Martin
Gombaský, Marcel
Krajči, Peter
Kupec, Andrej
Poliačiková, Petra
Trenčan, Milan
Lesiak, Maciej
Dudek, Magdalena
Iwańczyk, Sylwia
Kałużna-Oleksy, Marta
Klotzka, Aneta
Przepióra, Agnieszka
Ong, Paul J L
Ho, Hee Hwa
Jafary, Fahim Hairder
Khoo, Deanna Zhi-Lin
Lee, Deborah Jin Hyun
Loh, Jason
Li, Cathy Haiyan
Ong, Elena See Peng
Tan, Geraldine Geok Cheng
Wong, Stephanie
Yu, Crystal Bo
Walton, Tony
Bloom, Jason
Chan, William
Duffy, Stephen
Freilich, Mark
Hengel, Christopher
Htun, Nay
Peter, Karlheinz
Prakash, Roshan
Shaw, James
Stehli, Julia
Stub, Dion
Davidson, Brianna
Hammond, Louise H
Holland, Samantha
Johnston, Rozanne
Muir, Douglas
Bawamia, Bilal
Chapman, Michael
Vahabi, Sharareh
Williams, Paul
Athorne, Deborah
Atkinson, Beverley
Donnelly, Anthony
Mack, Stephanie
Manders, Tracy
Richardson, Catherine
Zaman, Azfar
Ahmed, Javed
Bagnall, Alan
Das, Rajiv
Edwards, Richard
Egred, Mohaned
Purcell, Ian
Spyridopoulos, Ioakim
Adams, Jennifer
Arkley, Michael
Bailey, Angela
Ebejer, Michela
Harrison, Ursula
Hetherington, Suzanne
Hindmarch, Paul
Lamb, Sarah
Matsvimbo, Pamela
Procter, Katherine
Quinn, Louise
Ward, Jane
Wealleans, Vera
Raffel, Christopher
Aroney, Nicholas
Chan, Julian
Dautov, Rustem
Gaikwad, Niranjan
Gopal, Kathikeyan
Markham, Ryan
Mishra, Akshay
Poon, Karl
Putrino, Anthony
Beevors, Estelle
Chu, Winnie Lai Cheung
Janoschka, Bo
Mearns, Megan
Phillips, Sandra
Roxas, Maricel
Rymar, Irena
Spencer, Suzanne
Stibijl, Kathryn
Sardella, Gennaro
Infusino, Fabio
Salvi, Nicolo
van der Harst, Pim
de Koning, Marie-Sophie
Groot, Hilde
Lipsic, Erik
Pundziute, Gabija
Schurer, Remco
Tan, Yong
van den Heuvel, Aloysius
van der Werf, Rik
Fröbert, Ole
Calais, Fredrik
Dhaha, Usama
Josefsson, Johan
Kellerth, Thomas
Marton, Laszlo
Zagozdzon, Leszek
Eriksson, Annika
Eriksson, Sandra
Hansson, Liselotte
Johansson, Magnus
Karlstrom, Kristina
Larsson, Liselotte
Thorsson, Amanda
Törnkvist, Eva
Desmet, Walter
Adriaenssens, Tom
Bennett, Johan
Dubois, Christophe
Marynissen, Thomas
McCutcheon, Keir Robert Gregor
Sinnaeve, Peter
Broos, Karin
Claes, Marina
Reniers, Sarah
van Roey, Sabina
Diderholm, Erik
Grimfjärd, Per
Kåregren, Amra
Saman, Saidi
Skoglund Andersson, Camilla
Voldberg, Birgitta
Andersson, Carina
Lundqvist, Marika
Myllylä, Lotta
Troquay, Roel
Aydin, Selahattin
Duygun, Ayse
Eerens, Filip
Frenk, Lisa
Rahel, B M
Remkes, Wouter
Daniels, Richard
Doesborg, Loek
Hattu, Lilian
Peeters, Conny
Baranauskas, Arvydas
Abraitis, Vytautas
Davidavičius, Giedrius
Radauskaitė, Greta
Solovjova, Svetlana
Baltokaitė, Lina
Gaidamavičiūtė, Violeta
Urbonaitė, Eglė
Pasupati, Sanjeevan
Fisher, Raewyn
Hamilton, Fraser
Heald, Spencer
Khurana, Akshat
Vun Liew, Tze
Menon, Madhav
Michael, Amit
Ali, Faaez Mohammed
Nair, Rajesh
Nizar, Ahmad
Nunn, Christopher
Pera, Vijaya
Sebastian, Cherian
Thaneeru, Pavan
Wolbinski, Mariusz
Kirk, Melissa
Low, Liz
Pillay, Roselyn
Harding, Scott
Aitken, Andrew
Fairley, Sarah
Ranchord, Anil
Wilkins, Benjamin
Davies, Bronwyn
Middleditch, Diane
Wylie, Donna
Yoon, Junghan
Ahn, Min Soo
Ahn, Sung Gyun
Kim, Jang Young
Lee, Jun-Won
Lee, Seung Hwan
Park, Sang Wook
Son, Jung-Woo
Yoo, Byung-Su
Ahn, Hae Jung
Han, Sunhui
Jang, Hye Suk
Shin, Seon Mi
Woo, Jung Ja
More authors (879 more) Less
Language :
English
Title :
Polymer-based or Polymer-free Stents in Patients at High Bleeding Risk.
Publication date :
26 March 2020
Journal title :
New England Journal of Medicine
ISSN :
0028-4793
eISSN :
1533-4406
Publisher :
Massachusetts Medical Society, Us ma
Volume :
382
Issue :
13
Pages :
1208-1218
Peer reviewed :
Peer Reviewed verified by ORBi
Funding number :
Funded the ONYX ONE Trial/Medtronic/International
Commentary :
Copyright © 2020 Massachusetts Medical Society.
Available on ORBi :
since 24 June 2022

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