Diffusion tensor imaging; First episode psychosis; Formal thought disorder; Inferior frontooccipital fasciculus; Schizophrenia; Semantic impairment; Anisotropy; Diffusion Tensor Imaging; Humans; Nerve Net; Neural Pathways/diagnostic imaging; Semantics; Schizophrenia/complications; Schizophrenia/diagnostic imaging; White Matter/diagnostic imaging; Neural Pathways; White Matter; Psychiatry and Mental Health; Biological Psychiatry
Abstract :
[en] The core symptoms of schizophrenia spectrum disorders (SSD) include abnormal semantic processing which may rely on the ventral language stream of the human brain. Thus, structural disruption of the ventral language stream may play an important role in semantic deficits observed in SSD patients. Therefore, we compared white matter tract integrity in SSD patients and healthy controls using diffusion tensor imaging combined with probabilistic fiber tractography. For the ventral language stream, we assessed the inferior fronto-occipital fasciculus [IFOF], inferior longitudinal fasciculus, and uncinate fasciculus. The arcuate fasciculus and corticospinal tract were used as control tracts. In SSD patients, the relationship between semantic processing impairments and tract integrity was analyzed separately. Three-dimensional tract reconstructions were performed in 45/44 SSD patients/controls ("Bern sample") and replicated in an independent sample of 24/24 SSD patients/controls ("Basel sample"). Multivariate analyses of fractional anisotropy, mean, axial, and radial diffusivity of the left IFOF showed significant differences between SSD patients and controls (p(FDR-corr) < 0.001, ηp2 = 0.23) in the Bern sample. Axial diffusivity (AD) of the left UF was inversely correlated with semantic impairments (r = -0.454, p(FDR-corr) = 0.035). In the Basel sample, significant group differences for the left IFOF were replicated (p < .01, ηp2 = 0.29), while the correlation between AD of the left IFOF and semantic processing decline (r = -0.376, p = .09) showed a statistical trend. No significant effects were found for the dorsal language stream. This is direct evidence for the importance of the integrity of the ventral language stream, in particular the left IFOF, in semantic processing deficits in SSD.
Disciplines :
Neurology Surgery
Author, co-author :
Surbeck, Werner; Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital of the University of Zurich, Zurich, Switzerland, Department of Neuroanatomy, Faculty of Medicine, University of Liège, Liège, Belgium, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital of the University of Zurich, Zurich, Switzerland. Electronic address: werner.surbeck@puk.zh.ch
Hänggi, Jürgen; Division Neuropsychology, Department of Psychology, University of Zurich, Zurich, Switzerland
Scholtes, Félix ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Nervous system disorders and therapy ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurochirurgie
Viher, Petra V; Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland
Schmidt, André ; Department of Psychiatry (UPK), University of Basel, Basel, Switzerland
Stegmayer, Katharina; Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland
Studerus, Erich; Department of Psychiatry (UPK), University of Basel, Basel, Switzerland
Lang, Udine E; Department of Psychiatry (UPK), University of Basel, Basel, Switzerland
Riecher-Rössler, Anita; Medical Faculty, University of Basel, Basel, Switzerland
Strik, Werner; Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland
Seifritz, Erich; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital of the University of Zurich, Zurich, Switzerland, Neuroscience Center Zurich, University and ETH, Zurich, Switzerland
Borgwardt, Stefan ; Department of Psychiatry (UPK), University of Basel, Basel, Switzerland, Department of Psychiatry and Psychotherapy, University of Lübeck, Germany
Quednow, Boris B; Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital of the University of Zurich, Zurich, Switzerland, Neuroscience Center Zurich, University and ETH, Zurich, Switzerland
Walther, Sebastian; Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland
This study received funding from the Swiss National Science Foundation (grant # 152619 to Sebastian Walther) and the Bangerter-Rhyner-Foundation (to Sebastian Walther).
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