Vaccinia virus immune evasion

Smith, G. L.; Symons, J. A.; Khanna, A.; Vanderplasschen, Alain; Alcami, A.

doi:10.1111/j.1600-065X.1997.tb01012.x

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Vaccinia virus immune evasion

Smith, G. L.; Symons, J. A.; Khanna, A. et al.

1997 • In Immunological Reviews, 159, p. 137-154

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10.1111/j.1600-065X.1997.tb01012.x

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9416508

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Abstract :

[en] Vaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include proteins which oppose apoptosis. Synthesise steroids, capture chemokines, counteract complement, interfere with interferon and intercept interleukins. This review provides an overview of such proteins, with an emphasis on work from our laboratory, and illustrates how the study of these proteins can increase our understanding of virus pathogenesis, the function of the immune system and how to make safer and more immunogenic poxvirus-based vaccines.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Smith, G. L.

Symons, J. A.

Khanna, A.

Vanderplasschen, Alain ; Université de Liège - ULiège > Immunologie et vaccinologie

Alcami, A.

Language :

English

Title :

Vaccinia virus immune evasion

Publication date :

1997

Journal title :

Immunological Reviews

ISSN :

0105-2896

eISSN :

1600-065X

Publisher :

Munksgaard International Publishers, Copenhagen, Denmark

Volume :

159

Pages :

137-154

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 November 2009

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181

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