oncology; radiation oncology; radiotherapy; lung cancer; pneumonitis; bronchoalveolar lavage fluid; transforming growth factor beta1; interleukin-6; oncologie; radiothérapie oncologie; radiothérapie; cancer du poumon; liquide de lavage bronchoalvéolaire; TGFbeta1; Il-6
Abstract :
[en] Transforming growth factor beta1 and Interleukin-6 were measured in the bronchoalveolar lavage fluid of lung cancer patients having received radiotherapy as part of their treatment. Il-6 concentrations remained unchanged during the follow-up period. On the contrary, TGFbeta1 increased continuously and paralleled to severity of pneumonitis. Our study suggests that this profibrogenic cytokine might be involved in radiation-induced lung injury.
Disciplines :
Oncology
Author, co-author :
BARTHELEMY, Nicole ; ULiège - Université de Liège > Département des sciences cliniques > Service de Radiothérapie
Bosquée, Lionel; CHR de la Citadelle Liège
BARTSCH, Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique
Deneufbourg, Jean-Marie ; Université de Liège - ULiège > Département des sciences cliniques > Radiothérapie
Nusgens, Betty; ULiège - Université de Liège > Laboratoire du tissu conjonctif
Language :
English
Title :
Thoracic Radiotherapy for Lung Cancer Increases Local Concentrations of Transforming Growth Factor beta1 (TGFbeta1)
Publication date :
September 2002
Number of pages :
138 P37
Event name :
32nd Annual Meeting of the European Society for Radiation Biology ESRB
