Article (Scientific journals)
Pituitary MRI Features in Acromegaly Resulting From Ectopic GHRH Secretion From a Neuroendocrine Tumor: Analysis of 30 Cases
NECHIFOR - POTORAC, Iulia; BONNEVILLE, Jean-François; Daly, Adrian et al.
2022In Journal of Clinical Endocrinology and Metabolism, p. 274
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Abstract :
[en] Ectopic acromegaly is a consequence of rare neuroendocrine tumors (NET) that secrete growth hormone releasing hormone (GHRH). This abnormal GHRH secretion drives growth hormone (GH) and insulin-like growth factor 1 (IGF-1) excess, with a clinical presentation similar to classical pituitary acromegaly. Identifying the underlying cause for the GH hypersecretion in the setting of ectopic GHRH excess is, however, essential for proper management both of acromegaly and the NET. Owing to its rarity, the imaging characteristics of the pituitary in ectopic acromegaly have not been analyzed in depth in large series.Characterize pituitary magnetic resonance imaging (MRI) features at baseline and after NET treatment in patients with ectopic acromegaly.Multicenter, international, retrospectiveTertiary referral pituitary centers30 ectopic acromegaly patients due to GHRH hypersecretionNoneMRI characteristics of pituitary gland, particularly T2-weighted signalIn 30 patients with ectopic GHRH-induced acromegaly, we found that most patients had hyperplastic pituitaries. Hyperplasia was usually moderate but was occasionally subtle, with only small volume increases compared to normal ranges for age and sex. T2-weighted signal was hypointense in most patients, especially in those with hyperplastic pituitaries. After treatment of the NET, pituitary size diminished and T2-weighted signal tended to normalize.This comprehensive study of pituitary MRI characteristics in ectopic acromegaly underlines the utility of performing T2-weighted sequences in the MRI evaluation of patients with acromegaly as an additional tool that can help to establish the correct diagnosis.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
NECHIFOR - POTORAC, Iulia ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'endocrinologie clinique
BONNEVILLE, Jean-François ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Daly, Adrian  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'endocrinologie clinique
de Herder, Wouter
Fainstein-Day, Patricia
Chanson, Philippe
Korbonits, Marta
Cordido, Fernando
Lamback, Elisa Baranski
Abid, Mohamed
Raverot, Véronique
Raverot, Gerald
Anda Apiñániz, Emma
Caron, Philippe
Du Boullay, Helene
Bildingmaier, Martin
Bolanowski, Marek
Laloi-Michelin, Marie
Borson-Chazot, Francoise
Chabre, Olivier
Christin-Maitre, Sophie
Briet, Claire
Diaz-Soto, Gonzalo
Bonneville, Fabrice
Castinetti, Frederic
Gadelha, Mônica R
Santana, Nathalie Oliveira
Stelmachowska-Banaś, Maria
Gudbjartsson, Tomas
Villar-Taibo, Roció
Zornitzki, Taiba
TSHIBANDA, Luaba ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
PETROSSIANS, Patrick  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'endocrinologie clinique
BECKERS, Albert ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
More authors (24 more) Less
Language :
English
Title :
Pituitary MRI Features in Acromegaly Resulting From Ectopic GHRH Secretion From a Neuroendocrine Tumor: Analysis of 30 Cases
Publication date :
04 May 2022
Journal title :
Journal of Clinical Endocrinology and Metabolism
ISSN :
0021-972X
eISSN :
1945-7197
Publisher :
Oxford University Press, New York, Us ny
Pages :
dgac274
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 June 2022

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