Alzheimer’s disease; Confabulations; Time distortions; Time perception; Humans; Knowledge; Memory; Neuropsychological Tests; Alzheimer Disease/complications; Memory Disorders; Time Perception; Neuropsychology and Physiological Psychology; Clinical Psychology; Psychiatry and Mental Health; General Medicine
Abstract :
[en] OBJECTIVES: We investigated the relationship between confabulations and the ability to process chronological characteristics of memories in Alzheimer's Disease (AD).
METHODS: We evaluated provoked confabulations, spontaneous confabulations, and time perception in 31 AD patients. We evaluated provoked confabulations with questions probing general and personal knowledge. We evaluated spontaneous confabulations with a scale rated by nursing and medical staff. Regarding time perception, we invited the participants to perform a simple ongoing activity (i.e., deciding whether words were abstract or concrete), in order to provide a verbal estimation of the elapsed time intervals.
RESULTS: We observed significant positive correlations between provoked/spontaneous confabulations and deviations in time estimation on the time perception task.
CONCLUSIONS: These findings demonstrate a relationship between confabulations in AD and difficulties in processing the chronological characteristics of elapsed events.
Disciplines :
Neurosciences & behavior
Author, co-author :
El Haj, Mohamad; Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638), Nantes Université, Univ Angers, F-44000 Nantes, France ; Centre Hospitalier de Tourcoing, Unité de Gériatrie, Tourcoing, France ; Institut Universitaire de France, Paris, France
Laroi, Frank ; Université de Liège - ULiège > Département de Psychologie ; Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway
Language :
English
Title :
Confabulations on Time: Relationship between Confabulations and Timing Deviations in Alzheimer's Disease.
EU - European Union ERDF - European Regional Development Fund
Funding text :
The study was supported by the LABEX (excellence laboratory, program investment for the future), DISTALZ (Development of Innovative Strategies for a Transdisciplinary Approach to Alzheimer Disease), and the EU Interreg 2 Seas Programme 2014– 2020 (co-funded by the European Regional Development Fund).
APA (2013). Diagnostic and statistical manual of mental disorder (Vol. 5th ed, DSM-5). Washington, DC: APA.
Barba, G. D. (1993). Confabulation: Knowledge and recollective experience. Cognitive Neuropsychology, 10(1), 1-20. doi: 10.1080/02643299308253454.
Block, R. A., & Zakay, D. (1996). Models of psychological time revisited. In Helfrich, H. (Ed.), Time and mind (, pp. 171-195). Kirkland, WA: Hogrefe & Huber.
Block, R. A., Zakay, D., & Hancock, P. A. (1998). Human aging and duration judgments: A meta-analytic review. Psychology and Aging, 13(4), 584-596.
Brown, S. W. (1985). Time perception and attention: The effects of prospective versus retrospective paradigms and task demands on perceived duration.
Perception and Psychophysics, 38(2), 115-124.
Carrasco, C., Guillem, M. J., &Redolat, R. (2000). Estimation of short temporal intervals in Alzheimer's disease. Experimental Aging Research, 26(2), 139-151. doi: 10.1080/036107300243605.
Caselli, L., Iaboli, L., & Nichelli, P. (2009). Time estimation in mild Alzheimer's disease patients. Behavioral and Brain Functions, 5, 32. doi: 10.1186/1744-9081-5-32.
Coltheart, M. (2016). Confabulation and conversation. Cortex, 87, 44-51. doi: 10.1016/j.cortex.2016.08.002.
Content, A., Mousty, P., &Radeau, M. (1990). BRULEX.Une base de données lexicales informatisée pour le français écrit et parlé.=BRULEX:Acomputerized lexical data base for the French language. L'Année Psychologique, 90(4), 551-566. doi: 10.3406/psy.1990.29428.
Dalla Barba, G., Brazzarola, M., Marangoni, S., Barbera, C., & Zannoni, I. (2016). A longitudinal study of confabulation. Cortex 87, 44-51. doi: 10.1016/j.cortex.2016.05.009.
Dalla Barba, G., Cappelletti, J. Y., Signorini, M., & Denes, G. (1997). Confabulation: Remembering 'another' past, planning 'another' future. Neurocase, 3(6), 425-436. doi: 10.1080/13554799708405018.
Dalla Barba, G., Nedjam, Z., & Dubois, B. (1999). Confabulation, executive functions, and source memory in Alzheimer's disease. Cognitive Neuropsychology, 16(3-5), 385-398. doi: 10.1080/026432999380843.
El Haj, M., Antoine, P., Amouyel, P., Lambert, J. C., Pasquier, F., & Kapogiannis, D. (2016). Apolipoprotein E (APOE) epsilon4 and episodic memory decline in Alzheimer's disease: A review. Ageing Research Reviews, 27, 15-22. doi: 10.1016/j.arr.2016.02.002.
El Haj, M., & Kapogiannis, D. (2016). Time distortions in Alzheimer's disease: A systematic review and theoretical integration. Npj Aging And Mechanisms of Disease, 2, 16016. doi: 10.1038/npjamd.2016.16.
El Haj, M., & Larøi, F. (2017). Provoked and spontaneous confabulations in Alzheimer's disease: An examination of their prevalence and relation with general cognitive and executive functioning. Psychiatry and Clinical Neurosciences, 71(1), 61-69. doi: 10.1111/pcn.12468.
El Haj, M., Moroni, C., Samson, S., Fasotti, L., & Allain, P. (2013). Prospective and retrospective time perception are related to mental time travel: Evidence from Alzheimer's disease. Brain and Cognition, 83(1), 45-51. doi: 10.1016/j.bandc.2013.06.008.
El Haj, M., Omigie, D., & Moroni, C. (2014). Time reproduction during high and low attentional tasks in Alzheimer's disease "a watched kettle never boils".
Brain and Cognition, 88(0), 1-5. doi: 10.1016/j.bandc.2014.04.002.
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189-198.
Fotopoulou, A., Conway, M. A., & Solms, M. (2007). Confabulation: Motivated reality monitoring. Neuropsychologia, 45(10), 2180-2190. doi: 10.1016/j.neuropsychologia.2007.03.003.
Fraisse, P. (1984). Perception and estimation of time. Annual Review of Psychology, 35, 1-36. doi: 10.1146/annurev.ps.35.020184.000245.
Fuld, P. A. (1977). Fuld object-memory evaluation. Chicago: Stoelting Instrument.
Gooch, C. M., Stern, Y., & Rakitin, B. C. (2009). Evidence for age-related changes to temporal attention and memory from the choice time production task.
Neuropsychology, Development, and Cognition. Section B: Aging, Neuropsychology and Cognition, 16(3), 285-310. doi: 10.1080/13825580802592771.
Graham, F. K., & Kendall, B. S. (1960). Memory-for-designs test: Revised general manual. Perceptual and Motor Skills, 11(2), 147-188. doi: 10.2466/pms.1960.11.2.147.
Grober, E., & Buschke, H. (1987). Genuine memory deficits in dementia. Developmental Neuropsychology, 3(1), 13-36.
Johnson, M. K., Hayes, S. M., D'Esposito, M., & Raye, C. (2000). Confabulation. In Boller, F., & Grafman, J. (Eds.), Handbook of neuropsychology, memory and its disorders (2nd ed., Vol. 2, pp. 383-407). Amsterdam, Netherlands: Elsevier Science.
Johnson, M. K., O'Connor, M., & Cantor, J. (1997). Confabulation, memory deficits, and frontal dysfunction. Brain and Cognition, 34(2), 189-206. doi: 10.1006/brcg.1997.0873.
Kern, R. S., Van Gorp, W. G., Cummings, J. L., Brown, W. S., & Osato, S. S. (1992). Confabulation in Alzheimer's disease. Brain and Cognition, 19(2), 172-182.
Kessels, R. P., Kortrijk, H. E., Wester, A. J., & Nys, G.M. (2008). Confabulation behavior and false memories in Korsakoff's syndrome: Role of source memory and executive functioning. Psychiatry and Clinical Neurosciences, 62(2), 220-225. doi: 10.1111/j.1440-1819.2008.01758.x.
Kopelman, M. D. (1987). Two types of confabulation. Journal of Neurology, Neurosurgery and Psychiatry, 50(11), 1482-1487.
Kopelman, M. D. (2010). Varieties of confabulation and delusion. Cognitive Neuropsychiatry, 15(1), 14-37. doi: 10.1080/13546800902732830.
Lustig, C., & Meck, W. H. (2001). Paying attention to time as one gets older. Psychological Science, 12(6), 478-484. doi: 10.1111/1467-9280.00389.
Lustig, C., & Meck, W. H. (2011). Modality differences in timing and temporal memory throughout the lifespan. Brain and Cognition, 77(2), 298-303. doi: 10.1016/j.bandc.2011.07.007.
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Jr., Kawas, C. H., et al. (2011). The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement, 7(3), 263-269. doi: 10.1016/j.jalz.2011.03.005.
Mulligan, R. M., &Schiffman, H. R. (1979). Temporal experience as a function of organization inmemory. Bulletin of the Psychonomic Society, 14(6), 417-420. doi: 10.3758/bf03329496.
Nahum, L., Bouzerda-Wahlen, A., Guggisberg, A., Ptak, R., & Schnider, A. (2012). Forms of confabulation: Dissociations and associations. Neuropsychologia, 50(10), 2524-2534. doi: 10.1016/j.neuropsychologia.2012.06.026.
Nichelli, P., Venneri, A., Molinari, M., Tavani, F., & Grafman, J. (1993). Precision and accuracy of subjective time estimation in different memory disorders. Brain Research: Cognitive Brain Research, 1(2), 87-93.
Papagno, C., Allegra, A., & Cardaci, M. (2004). Time estimation in Alzheimer's disease and the role of the central executive. Brain and Cognition, 54(1), 18-23.
Rueda, A. D., & Schmitter-Edgecombe, M. (2009). Time estimation abilities in mild cognitive impairment and Alzheimer's disease. Neuropsychology, 23(2), 178-188. doi: 10.1037/a0014289.
Schnider, A. (2008). The confabulating mind: How the brain creates reality. New York: Oxford University Press.
Schnider, A., & Ptak, R. (1999). Spontaneous confabulators fail to suppress currently irrelevant memory traces. Nature Neuroscience, 2(7), 677-681. doi: 10.1038/10236.
Schnider, A., von Daniken, C., & Gutbrod, K. (1996). The mechanisms of spontaneous and provoked confabulations. Brain, 119(Pt 4), 1365-1375.
Tiling, T. (1892). Ueber die amnestische Geistesstorung. Allgemeine Zeitschrift für Psychiatrie und psychisch-gerichtliche Medicin, 48, 549-565.
Victor, M., Adams, R. D., & Collins, G. H. (1971). The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations. Contemporary Neurology Series, 7, 1-206.
Vitacco, M. J., Jackson, R. L., Rogers, R., Neumann, C. S., Miller, H. A., & Gabel, J. (2008). Detection strategies for malingering with the Miller forensic assessment of symptoms test: A confirmatory factor analysis of its underlying dimensions. Assessment, 15(1), 97-103. doi: 10.1177/1073191107308085.
Wechsler, D. (1945). A standardized memory scale for clinical use. The Journal of Psychology, 19(1), 87-95. doi: 10.1080/00223980.1945.9917223.
