Article (Scientific journals)
Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging.
Marwick, Thomas H; Gimelli, Alessia; Plein, Sven et al.
2022In European Heart Journal. Cardiovascular Imaging, 23 (2), p. 62-e84
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Keywords :
Consensus; Diabetes Mellitus; Diastole; Heart Failure/diagnostic imaging/therapy; Humans; Microcirculation; Ventricular Dysfunction, Left/diagnostic imaging/etiology/therapy; diabetic cardiomyopathy; heart failure; mechanisms; screening;  diabetes
Abstract :
[en] Heart failure (HF) is among the most important and frequent complications of diabetes mellitus (DM). The detection of subclinical dysfunction is a marker of HF risk and presents a potential target for reducing incident HF in DM. Left ventricular (LV) dysfunction secondary to DM is heterogeneous, with phenotypes including predominantly systolic, predominantly diastolic, and mixed dysfunction. Indeed, the pathogenesis of HF in this setting is heterogeneous. Effective management of this problem will require detailed phenotyping of the contributions of fibrosis, microcirculatory disturbance, abnormal metabolism, and sympathetic innervation, among other mechanisms. For this reason, an imaging strategy for the detection of HF risk needs to not only detect subclinical LV dysfunction (LVD) but also characterize its pathogenesis. At present, it is possible to identify individuals with DM at increased risk HF, and there is evidence that cardioprotection may be of benefit. However, there is insufficient justification for HF screening, because we need stronger evidence of the links between the detection of LVD, treatment, and improved outcome. This review discusses the options for screening for LVD, the potential means of identifying the underlying mechanisms, and the pathways to treatment.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Marwick, Thomas H;  Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004,
Gimelli, Alessia ;  Fondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124 Pisa, Italy.
Plein, Sven ;  Multidisciplinary Cardiovascular Research Center & Leeds Institute of
Bax, Jeroen J ;  Department of Cardiology, Leiden University Medical Centre (LUMC), Leiden, The
Charron, Phillippe;  Sorbonne Université, INSERM UMRS 1166 and ICAN Institute, Paris, France. ; APHP, Centre de référence pour les maladies cardiaques héréditaires ou rares,
Delgado, Victoria ;  Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2
Donal, Erwan ;  Service de Cardiologie Et Maladies Vasculaires Et CIC-IT 1414, CHU Rennes, 35000  ; Université de Rennes 1, LTSI, 35000 Rennes, France.
LANCELLOTTI, Patrizio  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie ; Gruppo Villa Maria Care and Research, Maria Cecilia Hospital, Cotignola
Levelt, Eylem;  Department of Cardiovascular Sciences, University of Leicester, Glenfield
Maurovich-Horvat, Pal;  MTA-SE Cardiovascular Imaging Research Group, Medical Imaging Centre, Semmelweis
Neubauer, Stefan ;  Radcliffe Department of Medicine, University of Oxford Centre for Clinical
Pontone, Gianluca ;  Centro Cardiologico Monzino IRCCS, University of Milan, Cardiovascular Imaging
Saraste, Antti;  Turku PET Centre, University of Turku, Turku, Finland. ; Heart Center, Turku University Hospital, Turku, Finland.
Cosyns, Bernard ;  Cardiology, CHVZ (Centrum voor Hart en Vaatziekten), ICMI (In Vivo Cellular and
Edvardsen, Thor ;  Department of Cardiology, Oslo University Hospital, Rikshospitalet, Postbox 4950  ; Institute for clinical medicine, University of Oslo, Sognsvannsveien 20, NO-0424
Popescu, Bogdan A;  Department of Cardiology, University of Medicine and Pharmacy "Carol Davila",
Galderisi, Maurizio;  Department of Advanced Biomedical Sciences, Federico II University, Naples,
Derumeaux, Genevieve;  IMRB - Inserm U955 Senescence, metabolism and cardiovascular diseases 8, rue du
Reviewers: This document was reviewed by members of the 2020–2022 EACVI
Bäck, Magnus
Bertrand, Philippe B
Dweck, Marc
Keenan, Niall
Magne, Julien
Neglia, Danilo
Stankovic, Ivan
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Language :
Title :
Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging.
Publication date :
24 January 2022
Journal title :
European Heart Journal. Cardiovascular Imaging
Volume :
Issue :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Funding number :
CH/16/2/32089/BHF_/British Heart Foundation/United Kingdom; RG/16/1/32092/BHF_/British Heart Foundation/United Kingdom
Commentary :
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email:
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since 24 May 2022


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