Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging.
Marwick, Thomas H; Gimelli, Alessia; Plein, Svenet al.
2022 • In European Heart Journal. Cardiovascular Imaging, 23 (2), p. 62-e84
[en] Heart failure (HF) is among the most important and frequent complications of diabetes mellitus (DM). The detection of subclinical dysfunction is a marker of HF risk and presents a potential target for reducing incident HF in DM. Left ventricular (LV) dysfunction secondary to DM is heterogeneous, with phenotypes including predominantly systolic, predominantly diastolic, and mixed dysfunction. Indeed, the pathogenesis of HF in this setting is heterogeneous. Effective management of this problem will require detailed phenotyping of the contributions of fibrosis, microcirculatory disturbance, abnormal metabolism, and sympathetic innervation, among other mechanisms. For this reason, an imaging strategy for the detection of HF risk needs to not only detect subclinical LV dysfunction (LVD) but also characterize its pathogenesis. At present, it is possible to identify individuals with DM at increased risk HF, and there is evidence that cardioprotection may be of benefit. However, there is insufficient justification for HF screening, because we need stronger evidence of the links between the detection of LVD, treatment, and improved outcome. This review discusses the options for screening for LVD, the potential means of identifying the underlying mechanisms, and the pathways to treatment.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Marwick, Thomas H; Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004,
Plein, Sven ; Multidisciplinary Cardiovascular Research Center & Leeds Institute of
Bax, Jeroen J ; Department of Cardiology, Leiden University Medical Centre (LUMC), Leiden, The
Charron, Phillippe; Sorbonne Université, INSERM UMRS 1166 and ICAN Institute, Paris, France. ; APHP, Centre de référence pour les maladies cardiaques héréditaires ou rares,
Delgado, Victoria ; Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2
Donal, Erwan ; Service de Cardiologie Et Maladies Vasculaires Et CIC-IT 1414, CHU Rennes, 35000 ; Université de Rennes 1, LTSI, 35000 Rennes, France.
LANCELLOTTI, Patrizio ; Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie ; Gruppo Villa Maria Care and Research, Maria Cecilia Hospital, Cotignola
Levelt, Eylem; Department of Cardiovascular Sciences, University of Leicester, Glenfield
Maurovich-Horvat, Pal; MTA-SE Cardiovascular Imaging Research Group, Medical Imaging Centre, Semmelweis
Neubauer, Stefan ; Radcliffe Department of Medicine, University of Oxford Centre for Clinical
Pontone, Gianluca ; Centro Cardiologico Monzino IRCCS, University of Milan, Cardiovascular Imaging
Saraste, Antti; Turku PET Centre, University of Turku, Turku, Finland. ; Heart Center, Turku University Hospital, Turku, Finland.
Cosyns, Bernard ; Cardiology, CHVZ (Centrum voor Hart en Vaatziekten), ICMI (In Vivo Cellular and
Edvardsen, Thor ; Department of Cardiology, Oslo University Hospital, Rikshospitalet, Postbox 4950 ; Institute for clinical medicine, University of Oslo, Sognsvannsveien 20, NO-0424
Popescu, Bogdan A; Department of Cardiology, University of Medicine and Pharmacy "Carol Davila",
Galderisi, Maurizio; Department of Advanced Biomedical Sciences, Federico II University, Naples,
Derumeaux, Genevieve; IMRB - Inserm U955 Senescence, metabolism and cardiovascular diseases 8, rue du
Reviewers: This document was reviewed by members of the 2020–2022 EACVI
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