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Article (Scientific journals)
Experimental African Trypanosome Infection by Needle Passage or Natural Tsetse Fly Challenge Thwarts the Development of Collagen-Induced Arthritis in DBA/1 Prone Mice via an Impairment of Antigen Specific B Cell Autoantibody Titer
De Trez, Carl; Katsandegwaza, Brunette; Caljon, Guy et al.
2015In PLoS ONE, 10 (6), p. 0130431
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Keywords :
Multidisciplinary; Immunology; Murine
Abstract :
[en] Collagen-induced arthritis is a B cell-mediated autoimmune disease. Recently published studies have demonstrated that in some rare cases pathogens can confer protection from autoimmunity. Trypanosoma brucei parasites are tsetse fly transmitted extracellular protozoans causing sleeping sickness disease in humans and Nagana in livestock in sub-Saharan endemic areas. In the past, we demonstrated that trypanosome infections impair B cell homeostasis and abolish vaccine-induced protection against unrelated antigens. Hence, here we hypothesized that trypanosome infection can affect the onset of CIA by specifically dampening specific B-cell responses and type II collagen antibody titers in DBA/1 prone mice. We observed a substantial delay in the onset of collagen-induced arthritis in T. brucei-infected DBA/1 mice that correlates with a drastic decrease of type II collagen titers of the different IgG isotypes in the serum. Treatment of infected mice with Berenil, a trypanocidal drug, restored the development of CIA-associated clinical symptoms. Interestingly, these data were confirmed by the challenge of immunized DBA/1 prone mice with T. brucei-infected tsetse flies. Together, these results demonstrate that T. brucei infection is impairing the maintenance of the antigen specific plasma B cell pool driving the development of CIA in DBA/1 prone mice.
Research Center/Unit :
Vrije Universiteit Brussels
Disciplines :
Microbiology
Veterinary medicine & animal health
Author, co-author :
De Trez, Carl 
Katsandegwaza, Brunette   ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Immunologie vétérinaire
Caljon, Guy
Magez, Stefan
 These authors have contributed equally to this work.
Language :
English
Title :
Experimental African Trypanosome Infection by Needle Passage or Natural Tsetse Fly Challenge Thwarts the Development of Collagen-Induced Arthritis in DBA/1 Prone Mice via an Impairment of Antigen Specific B Cell Autoantibody Titer
Publication date :
25 June 2015
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science (PLoS)
Volume :
10
Issue :
6
Pages :
e0130431
Peer reviewed :
Peer Reviewed verified by ORBi
Funding text :
This work was supported by Fonds voor Wetenschappelijk Onderzoek (FWO) via a “Krediet aan Navorsers” grant # 1517313N/KN251 and Belgian Federal Science Policy Office via “Interuniversity Attraction Poles” grant # 7–41.
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