Drug properties; Gene annotation; Information visualization; Knowledge visualization; Overlapping set visualization; User study; Language and Linguistics; Human-Computer Interaction; Computer Science Applications
Abstract :
[en] Overlapping set visualization is a well-known problem in information visualization. This problem considers elements and sets containing all or part of the elements, a given element possibly belonging to more than one set. A typical example is the properties of the 20 amino-acids. A more complex application is the visual comparison of the contraindications or the adverse effects of several similar drugs. The knowledge involved is voluminous, each drug has many contraindications and adverse effects, some of them are shared with other drugs. Another real-life application is the visualization of gene annotation, each gene product being annotated with several annotation terms indicating the associated biological processes, molecular functions and cellular components. In this paper, we present rainbow boxes, a novel technique for visualizing overlapping sets, and its application to the presentation of the properties of amino-acids, the comparison of drug properties, and the visualization of gene annotation. This technique requires solving a combinatorial optimization problem; we propose a specific heuristic and we evaluate and compare it to general optimization algorithms. We also describe a user study comparing rainbow boxes to tables and showing that the former allowed physicians to find information significantly faster. Finally, we discuss the limits and the perspectives of rainbow boxes.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Lamy, Jean-Baptiste; LIMICS, Université Paris 13, France ; INSERM UMRS 1142, Paris, France
Berthelot, Hélène; LIMICS, Université Paris 13, France ; INSERM UMRS 1142, Paris, France
Capron, Coralie ; Université de Liège - ULiège > Département de pharmacie ; LIMICS, Université Paris 13, France ; INSERM UMRS 1142, Paris, France
Favre, Madeleine; Dept. of primary care, Université Paris Descartes, Paris, France
Language :
English
Title :
Rainbow boxes: A new technique for overlapping set visualization and two applications in the biomedical domain
ANSM - Agence Nationale de Sécurité du Médicament et des Produits de Santé
Funding text :
This work was supported by the French Drug Agency (ANSM, Agence Nationale de Sécurité du Médicament et des produits de santé ) through the VIIIP project [grant number AAP-2012-013 ].
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