Assessment of Toxoplasma Seropositivity in Children Suffering from Anxiety Disorders.

Afsharpaiman, Shahla; Khosravi, Mohammad Hossein; Mahmoodinejad, Mojtaba; Shirbazoo, Shahnaz; Amirsalari, Susan; Torkaman, Mohammad; Radfar, Shokoofeh

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Assessment of Toxoplasma Seropositivity in Children Suffering from Anxiety Disorders.

Afsharpaiman, Shahla; Khosravi, Mohammad Hossein; Mahmoodinejad, Mojtaba et al.

2017 • In Iranian Journal of Child Neurology, 11 (4), p. 32-37

Peer reviewed

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https://hdl.handle.net/2268/291092

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29201121

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Keywords :

Antibodies; Anxiety disorders; Toxoplasma gondii; Toxoplasmosis

Abstract :

[en] OBJECTIVE: This study aimed to assess the seroprevalence of Toxoplasma gondii in children with anxiety disorders. MATERIALS & METHODS: This cross-sectional study was conducted between Sep 2012 and May 2013 in Pediatrics Clinic of Baqiyatallah Hospital, Tehran, Iran. Children were assessed clinically. Diagnosis of patients with anxiety disorders was based on DSM-4 system, performed by child psychiatrist. Then their anti-Toxoplasma antibodies were measured. A questionnaire was verbally administered to all individuals' parents including demographic information and questions about life style, family history, medical history, economic situation, residence, nutritional patterns and contact with animals. RESULTS: Ninety-six male and female cases with a mean age of 8.56±2.5 and 8.42±1.9 yr underwent analysis. Anti- T. gondii IgG antibody was found in one case of each group. There was no significant difference between case and control groups for serum Toxoplasma IgG antibody (P=0.14). No case individuals had Anti- T. gondii IgM antibody, while it was found in one control individual. No significant difference was seen between case and control groups for Toxoplasma IgM antibody (P=0.27). CONCLUSION: Toxoplasmosis has no direct effect on the incidence of anxiety disorders. More studies are needed with a larger volume of individuals in future.

Disciplines :

Pediatrics

Author, co-author :

Afsharpaiman, Shahla; Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Khosravi, Mohammad Hossein ; Université de Liège - ULiège > Faculté de Médecine > Doct. sc. méd. (paysage)

Mahmoodinejad, Mojtaba; Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

Shirbazoo, Shahnaz; Department of Parasitology, Baqiyatallah University of Medical Sciences, Tehran, Iran

Amirsalari, Susan; New Hearing Technologies Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Torkaman, Mohammad; Department of Pediatrics, Baqiyatallah University of Medical Sciences, Tehran, Iran

Radfar, Shokoofeh; Psychiatry Department, Baqiyatallah University of Medical Sciences, Tehran, Iran

Language :

English

Title :

Assessment of Toxoplasma Seropositivity in Children Suffering from Anxiety Disorders.

Publication date :

2017

Journal title :

Iranian Journal of Child Neurology

ISSN :

1735-4668

eISSN :

2008-0700

Publisher :

The Iranian Child Neurology Society, Ir

Volume :

Issue :

Pages :

32-37

Peer reviewed :

Peer reviewed

Available on ORBi :

since 21 May 2022

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Bibliography

Association D-AP. Diagnostic and statistical manual of mental disorders. Arlington: American Psychiatric Publishing 2013.
Hay J, Hutchison W, Aitken P, Graham DI. The effect of congenital and adult-acquired Toxoplasma infections on activity and responsiveness to novel stimulation in mice. Ann Trop Med Parasitol 1983: 77: 483-495.
Sims T, Hay J. Host-parasite relationship between congenital Toxoplasma infection and mouse brain: role of small vessels. Parasitology 1995: 110: 123-127.
Hodková H, Kolbeková P, Skallová A, Lindová J, Flegr J. Higher perceived dominance in Toxoplasma infected men--a new evidence for role of increased level of testosterone in toxoplasmosis-associated changes in human behavior. Neuroendocrinol Lett 2007: 28: 110-114.
Stibbs H. Changes in brain concentrations of catecholamines and indoleamines in Toxoplasma gondii infected mice. Ann Trop Med Parasitol 1985: 79: 153-157.
Treuer T, Martenyi F, Karagianis J. Parasitosis, dopaminergic modulation and metabolic disturbances in schizophrenia: evolution of a hypothesis. Neuro Endocrinol Lett 2007: 28: 535-540.
Yuksel P, Alpay N, Babur C, et al. The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia-the risk factor or an indication of a contact with cat?. Folia Parasitol 2010: 57: 121.
Goodman W, Rasmussen S, Leckman JF. A family study of obsessive-compulsive disorder. Am J Psychiatry 1995: 152: 76-84.
Smadja D, Cabre P, Prat C, Vernant J. Loss of psychic auto-activation. Obsessive-compulsive behavior. Toxoplasmic abscess of the basal ganglia. Revue Neurologique 1995: 151: 271-273.
Piekarski G. Behavioral alterations caused by parasitic infection in case of latent toxoplasma infection. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene 1 Abt Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie 1981: 250: 403-406.
Yagmur F, Yazar S, Temel HO, Cavusoglu M. May Toxoplasma gondii increase suicide attempt-preliminary results in Turkish subjects?. Forensic Sci Int 2010: 199: 15-17.
Schiebe J HK. Patho-genetische Varianz und diagnostische Kriterien der Neurotoxoplasmose. Psychiat Neurol Med Psychol 1983: 35: 210-221
Brynska A, Tomaszewicz-Libudzic E, Wolanczyk T. Obsessive-compulsive disorder and acquired toxoplasmosis in two children. Europ Child Adol Psychiatry 2001: 10: 200-204.
Torrey EF, Yolken RH. Toxoplasma gondii and schizophrenia. Emerg Infect Dis 2003: 9: 1375.
Alvarado-Esquivel C, Urbina-Álvarez JD, Estrada-Martínez S, et al. Toxoplasma gondii infection and schizophrenia: a case control study in a low Toxoplasma seroprevalence Mexican population. Parasitol Int 2011: 60: 151-155.
Perez M, Brown JS, Vrshek-Schallhorn S, Johnson F, Joiner TE. Differentiation of obsessive-compulsive-, panic-, obsessive-compulsive personality-, and non-disordered individuals by variation in the promoter region of the serotonin transporter gene. J Anxiety Disord 2006: 20: 794-806.
Luu TM, Ment LR, Schneider KC, Katz KH, Allan WC, Vohr BR. Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age. Pediatrics 2009: 123: 1037-1044.
Elgen I, Sommerfelt K, Markestad T. Population based, controlled study of behavioural problems and psychiatric disorders in low birthweight children at 11 years of age. Arch Dis Child Fetal Neonatal Ed 2002: 87: F128-F132.
Abdoli A, Dalimi A. Are there any relationships between latent Toxoplasma gondii infection, testosterone elevation, and risk of autism spectrum disorder?. Frontiers Behav Neurosci 2014: 8.
Mufaddel A, Omer AA, Salem MO. Psychiatric aspects of infectious diseases. Open J Psychiatr 2014: 4: 202.
Markovitz AA, Simanek AM, Yolken RH, et al. Toxoplasma gondii and anxiety disorders in a community-based sample. Brain Behav Immun 2015: 43: 192-197.