[en] Brain metastases (BM) are severe incidents in patients with non-small-cell lung cancer (NSCLC). The controversial value of prophylactic cranial irradiation (PCI) in NSCLC in terms of survival benefit prompted us to explore the possible risk factors for BM in NSCLC and identify the potential population most likely to benefit from PCI. Risk factors for brain metastases in NSCLC are reviewed in this article. Identifying patients with a higher risk of BM could possibly increase the benefit of PCI while reducing the discomfort and risks caused by unnecessary invasive procedures in the NSCLC patient population. Future studies might focus on finding a solid basis for the prediction of the occurrence of brain metastases and for the therapeutic decision on the use of PCI.
Precision for document type :
Review article
Disciplines :
Oncology
Author, co-author :
An, Ning ; Université de Liège - ULiège > GIGA > GIGA Stem Cells - Cancer Signaling ; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong University, Jinan, China
Jing, Wang; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China
Wang, Haoyi; Department of Hematology, Qilu Hospital, Shandong University, Jinan, China
Li, Ji; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China
Liu, Yang; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China
Yu, Jinming; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China
Zhu, Hui ; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China
Language :
English
Title :
Risk factors for brain metastases in patients with non-small-cell lung cancer.
National Key Research & Development (R&D) Plan Key Research and Development Program of Shandong Province
Funding text :
This work was supported by the Key Research and Development Program of Shandong Province under Grant 2016GSF201148 (to Hui Zhu) and the National Key Research & Development (R&D) Plan under Grant 2016YFC0105708 (to Hui Zhu).
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