Assessment of the Response Profile to Hyaluronic Acid Plus Sorbitol Injection in Patients with Knee Osteoarthritis: Post-Hoc Analysis of a 6-Month Randomized Controlled Trial.
[en] In a previous randomized trial, the non-inferiority of two hyaluronic acid injections (Synolis VA versus Synvisc-One) was assessed in patients with knee OA, with a response rate of 79% for Synolis VA. To assess whether a responder profile could be established for this treatment modality, we used the Synolis VA arm of a published 6-month prospective, multicenter, comparative, randomized, double-blinded trial. At baseline and during the study, pain and function were assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire. Ninety-six subjects from the intention-to-treat trial were included in the analysis. The 6-month change of WOMAC Pain with Synolis VA was not associated with any baseline clinical data. However, the change in WOMAC Function was significantly associated with its baseline level, even after adjustment for potential confounding variables (p = 0.028), i.e., a poorer physical function at baseline was associated with a better response. In conclusion, in addition to the high absolute response rate to Synolis VA, the probability of success is even increased if administered in patients with more limited physical function at baseline. Further research with other potential confounding clinical variables is warranted in order to better applicate the concept of personalized medicine.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Honvo, Germain ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Vidovic, Eduard; Aptissen SA Medical Department, 1228 Plan-les-Ouates, Switzerland
Cortet, Bernard ; Department of Rheumatology and UR 4490, University Hospital of Lille, 59000 Lille, France
Language :
English
Title :
Assessment of the Response Profile to Hyaluronic Acid Plus Sorbitol Injection in Patients with Knee Osteoarthritis: Post-Hoc Analysis of a 6-Month Randomized Controlled Trial.
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Bibliography
Bruyere, O.; Honvo, G.; Veronese, N.; Arden, N.K.; Branco, J.; Curtis, E.M.; Al-Daghri, N.M.; Herrero-Beaumont, G.; Martel-Pelletier, J.; Pelletier, J.P.; et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin. Arthritis Rheum. 2019, 49, 337–350. [CrossRef] [PubMed]
Bannuru, R.R.; Osani, M.C.; Vaysbrot, E.E.; Arden, N.K.; Bennell, K.; Bierma-Zeinstra, S.M.A.; Kraus, V.B.; Lohmander, L.S.; Abbott, J.H.; Bhandari, M.; et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthr. Cartil. 2019, 27, 1578–1589. [CrossRef] [PubMed]
Maheu, E.; Bannuru, R.R.; Herrero-Beaumont, G.; Allali, F.; Bard, H.; Migliore, A. Why we should definitely include intra-articular hyaluronic acid as a therapeutic option in the management of knee osteoarthritis: Results of an extensive critical literature review. Semin. Arthritis Rheum. 2019, 48, 563–572. [CrossRef] [PubMed]
Honvo, G.; Reginster, J.Y.; Rannou, F.; Rygaert, X.; Geerinck, A.; Rabenda, V.; McAlindon, T.; Charles, A.; Fuggle, N.; Cooper, C.; et al. Safety of Intra-articular Hyaluronic Acid Injections in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. Drugs Aging 2019, 36, 101–127. [CrossRef] [PubMed]
Bannuru, R.R.; Osani, M.; Vaysbrot, E.E.; McAlindon, T.E. Comparative safety profile of hyaluronic acid products for knee osteoarthritis: A systematic review and network meta-analysis. Osteoarthr. Cartil. 2016, 24, 2022–2041. [CrossRef]
Altman, R.D.; Bedi, A.; Karlsson, J.; Sancheti, P.; Schemitsch, E. Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. Am. J. Sports Med. 2016, 44, 2158–2165. [CrossRef]
Cortet, B.; Lombion, S.; Naissant, B.; Vidovic, E.; Bruyere, O. Non-Inferiority of a Single Injection of Sodium Hyaluronate Plus Sorbitol to Hylan G-F20: A 6-Month Randomized Controlled Trial. Adv. Ther. 2021, 38, 2271–2283. [CrossRef] [PubMed]
Pham, T.; van der Heijde, D.; Altman, R.D.; Anderson, J.J.; Bellamy, N.; Hochberg, M.; Simon, L.; Strand, V.; Woodworth, T.; Dougados, M. OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthr. Cartil. 2004, 12, 389–399. [CrossRef] [PubMed]
Bruyere, O.; Dardenne, N.; Donneau, A.F.; Reginster, J.Y. Responder Profile to Pharmaceutical-Grade Chondroitin Sulfate: An Analysis of the CONCEPT Trial. Adv. Ther. 2020, 37, 4641–4648. [CrossRef] [PubMed]
Collantes-Estevez, E.; Fernandez-Perez, C. Improved control of osteoarthritis pain and self-reported health status in non-responders to celecoxib switched to rofecoxib: Results of PAVIA, an open-label post-marketing survey in Spain. Curr. Med. Res. Opin. 2003, 19, 402–410. [CrossRef] [PubMed]
Zhang, W.; Robertson, J.; Jones, A.C.; Dieppe, P.A.; Doherty, M. The placebo effect and its determinants in osteoarthritis: Meta-analysis of randomised controlled trials. Ann. Rheum. Dis. 2008, 67, 1716–1723. [CrossRef] [PubMed]
Migliore, A.; Massafra, U.; Bizzi, E.; Tormenta, S.; Cassol, M.; Granata, M. Duration of symptom relief after intra-articular injection of hyaluronic acid combined with sorbitol (anti-ox-vs) in symptomatic hip osteoarthritis. Int. J. Immunopathol. Pharmacol. 2014, 27, 245–252. [CrossRef] [PubMed]
Conrozier, T. Is the Addition of a Polyol to Hyaluronic Acid a Significant Advance in the Treatment of Osteoarthritis? Curr. Rheumatol. Rev. 2018, 14, 226–230. [CrossRef] [PubMed]
Mongkhon, J.M.; Thach, M.; Shi, Q.; Fernandes, J.C.; Fahmi, H.; Benderdour, M. Sorbitol-modified hyaluronic acid reduces oxidative stress, apoptosis and mediators of inflammation and catabolism in human osteoarthritic chondrocytes. Inflamm. Res. 2014, 63, 691–701. [CrossRef] [PubMed]
Webner, D.; Huang, Y.; Hummer, C.D., 3rd. Intraarticular Hyaluronic Acid Preparations for Knee Osteoarthritis: Are Some Better Than Others? Cartilage 2021. [CrossRef] [PubMed]
Costello, C.A.; Hu, T.; Liu, M.; Zhang, W.; Furey, A.; Fan, Z.; Rahman, P.; Randell, E.W.; Zhai, G. Differential correlation network analysis identified novel metabolomics signatures for non-responders to total joint replacement in primary osteoarthritis patients. Metabolomics 2020, 16, 61. [CrossRef] [PubMed]
Zhai, G.; Pelletier, J.P.; Liu, M.; Randell, E.W.; Rahman, P.; Martel-Pelletier, J. Serum lysophosphatidylcholines to phosphatidylcholines ratio is associated with symptomatic responders to symptomatic drugs in knee osteoarthritis patients. Arthritis Res. Ther. 2019, 21, 224. [CrossRef] [PubMed]
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