Article (Scientific journals)
Diverse echocardiographic changes in the course of hypoxia due to acute exacerbation of idiopathic pulmonary fibrosis.
Tsugu, Toshimitsu; Nagatomo, Yuji; Koh, Hidefumi et al.
2020In Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 48 (6), p. 619-622
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Keywords :
Glucocorticoids; S88TT14065 (Oxygen); X4W7ZR7023 (Methylprednisolone); Aged; Combined Modality Therapy; Disease Progression; Echocardiography/methods; Fatal Outcome; Glucocorticoids/administration & dosage/therapeutic use; Humans; Hypertension, Pulmonary/etiology/physiopathology; Hypoxia/complications/diagnostic imaging/drug therapy/therapy; Idiopathic Pulmonary Fibrosis/complications; Male; Methylprednisolone/administration & dosage/therapeutic use; Oxygen/therapeutic use; Oxygen Saturation; Pulse Therapy, Drug/methods; Tomography, X-Ray Computed/methods; Tricuspid Valve Insufficiency/physiopathology
Abstract :
[en] Idiopathic pulmonary fibrosis (IPF) is a progressive parenchymal disease. Pulmonary hypertension (PH) is a potentially lethal complication in the course of IPF. In almost all cases of IPF-PH there is gradual deterioration, but patients can also decline suddenly due to hypoxia. This case report describes the different echocardiographic changes observed in 2 episodes of hypoxic attack in a 73-year-old man. On admission, the tricuspid regurgitation peak gradient (TRPG) was 21 mmHg and the oxygen saturation rate was 94% (O2: 4 L/min). Five days after admission, the TRPG and oxygen saturation rate deteriorated [TRPG: 85 mmHg, oxygen saturation: 72% (O2; 4 L/min)]. He was diagnosed with IPF-PH due to hypoxic pulmonary vasoconstriction. Oxygen therapy and methylprednisolone pulse therapy (MPT) were administered. Five days after the MPT treatment, the hypoxia and PH improved [TRPG: 21 mmHg, oxygen saturation: 95% (O2: 4 L/min)]. Acute exacerbation of IPF (IPF-AE) occurred 20 days after the MPT, and a second dose of MPT was administered. The TRPG and oxygen saturation rate did not decline [TRPG: 27 mmHg, oxygen saturation: 94% (O2: 4 L/min)]. The patient died 10 days after the second dose of MPT. Divergent echocardiographic findings were observed during the deterioration of IPF-AE in the presence of IPF-PH.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Tsugu, Toshimitsu;  Department of Cardiology, Heart Valve Clinic, University of Liège Hospital, Giga
Nagatomo, Yuji;  Department of Cardiology, National Defense Medical College Hospital, Tokorozawa,
Koh, Hidefumi;  Division of Pulmonary Medicine, Federation of National Public Service Personnel
Tanaka, Kaoru;  Department of Radiology, Universitair Ziekenhuis Brussels, Belgium.
LANCELLOTTI, Patrizio  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie
Language :
English
Title :
Diverse echocardiographic changes in the course of hypoxia due to acute exacerbation of idiopathic pulmonary fibrosis.
Alternative titles :
[tr] İdiyopatik pulmoner fibrozun akut alevlenmesine bağlı olarak hipoksinin seyrindeki çeşitli ekokardiyografik değişiklikler.
Publication date :
September 2020
Journal title :
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
eISSN :
1308-4488
Volume :
48
Issue :
6
Pages :
619-622
Peer reviewed :
Peer reviewed
Available on ORBi :
since 18 May 2022

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