Article (Scientific journals)
Layer-specific longitudinal strain predicts left ventricular maximum wall thickness in patients with hypertrophic cardiomyopathy.
Tsugu, Toshimitsu; Nagatomo, Yuji; Dulgheru, Raluca et al.
2021In Echocardiography, 38 (7), p. 1149-1156
Peer reviewed
 

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Keywords :
Cardiomyopathy, Hypertrophic/diagnosis/diagnostic imaging; Echocardiography; Female; Heart Ventricles/diagnostic imaging; Humans; Male; Stroke Volume; Ventricular Function, Left; 2D echocardiography; hypertrophic cardiomyopathy; multilayer strain; segmental deformation; speckle tracking echocardiography
Abstract :
[en] AIMS: The aim of this study was (a) to clarify the detailed mechanisms of structural and functional abnormalities of myocardial tissue in hypertrophic cardiomyopathy (HCM) using layer-specific strain (LSS) and compare it with healthy subjects (b) to investigate the diagnostic accuracy of LSS for HCM. METHODS AND RESULTS: Forty-one patients with HCM and preserved left ventricular ejection fraction (LVEF; 66% male, 52 ± 18 years, LVEF 62.9% ± 3.7%) and 41 controls matched for age and sex (66% male, 52 ± 20 years, LVEF 63.5% ± 8.2%) underwent 2D-speckle tracking echocardiography. Absolute values of LSS were globally lower and the ratio of endocardial/epicardial layer (End/Epi ratio) was higher in HCM. LSS gradually increased from the epicardial toward the endocardial layer at all chamber views and at all levels of the LV. LSS and End/Epi ratio at the apex were higher than those at the middle or basal level of the LV. End/Epi ratio was correlated with LV maximal wall thickness both controls (r = .35, P = .03) and HCM (r = .81, P < .001). End/Epi ratio was an independent factor associated with LV maximal wall thickness (β = 0.96, P < .001). A higher End/Epi ratio (≥1.31) was associated with diagnostic criteria for HCM (sensitivity 98%, specificity 95%, area under the curve 0.99, P < .001). CONCLUSION: LSS has the potential for unraveling the mechanism of impaired LV wall motion in HCM and to accurately detect HCM.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Tsugu, Toshimitsu;  Departments of Cardiology, GIGA Cardiovascular Sciences, Heart Valve Clinic, CHU
Nagatomo, Yuji;  Department of Cardiology, National Defense Medical College Hospital, Tokorozawa,
Dulgheru, Raluca;  Departments of Cardiology, GIGA Cardiovascular Sciences, Heart Valve Clinic, CHU
LANCELLOTTI, Patrizio  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie ; Departments of Cardiology, GIGA Cardiovascular Sciences, Heart Valve Clinic, CHU
Language :
English
Title :
Layer-specific longitudinal strain predicts left ventricular maximum wall thickness in patients with hypertrophic cardiomyopathy.
Publication date :
July 2021
Journal title :
Echocardiography
ISSN :
0742-2822
eISSN :
1540-8175
Volume :
38
Issue :
7
Pages :
1149-1156
Peer reviewed :
Peer reviewed
Commentary :
© 2021 Wiley Periodicals LLC.
Available on ORBi :
since 18 May 2022

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