Reference : Approche statistique de l'influence de l'age et du sexe sur l'excretion de 6-sulfatox...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Approche statistique de l'influence de l'age et du sexe sur l'excretion de 6-sulfatoxymelatonine urinaire (a-MT6s) chez l'individu normal
[en] Urinary Excretion of 6-Sulphatoxymelatonin in Normal Subjects: Statistical Approach to the Influence of Age and Sex
Hendrick, J. C. [> > > >]
Crasson, Marion [Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale >]
Hagelstein, Marie-Thérèse mailto [Université de Liège - ULiège > > Endocrinologie clinique >]
Bruls, E. [> > > >]
Legros, Jean-Jacques mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Annales d'Endocrinologie
Yes (verified by ORBi)
Moulineaux Cedex 9
[en] melatonin, urinary 6-sulphatoxymelatonin (a-MT6s) ; age, humans
[en] A radioimmunoassay of urinary 6-sulphatoxymelatonin (a-MT6s) was performed in 90 normal subjects: 44 males and 46 females (17-67 years). Patients treated with betablokers or antidepressants were not included in this study. Urine samples were collected over three periods of time: 7 to 11 p.m., 11 p.m. to 7 a.m., and 7 to 11 a.m. Between 11 p.m. and 7 a.m., the subjects slept in their normal environment and had not ingested alcohol for 24 hours. We searched for a possible relation between urinary a-MT6s excretion (expressed in ng/l/h) and age. From 7 to 11 p.m. and from 7 to 11 a.m. no significant relation could be found. On the contrary, between 11 p.m. and 7 a.m. there was a significant relation indicating decrease of a-MT6s secretion with increasing age. Several linear or non-linear curve patters were tested: Boltzmann sigmoid (1(st), 2(nd), and 3(rd) degree), polynomial curves. The Boltzmann sigmoid showed the best fit judging by the r-squared value (0.152) and the runs test (p=0.64). On this curve the inflection point was located at 53 4 years (SDM, standard deviation of the mean). From 19 to 45 years, the upper sigmoid plateau was located at 1381 91 ng/l/h (SDM). The decrease was found between 45 and 60 years and the lower sigmoid plateau then stabilized at 467 370 ng/l/h (\SDM). In the study group, there was no significant difference between men and women according to the Mann-Withney test. Finally, use of oral contraceptives did not affect urinary a-MT6s (Mann-Withney).
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