[en] Abstract
Aims
Long-chain polyunsaturated fatty acids (PUFAs) generate diverse bioactive lipid mediators, which tightly regulate vascular inflammation. The effects of omega-3 PUFA supplementation in cardiovascular prevention however remain controversial. In addition to direct dietary intake, fatty acid desaturases (FADS) determine PUFA levels. Increased arterial stiffness represents an independent predictor of mortality and cardiovascular events. The aim of the present study was to determine the association of PUFA intake, FADS1 genotype, and FADS expression with arterial stiffness.
Methods and results
A cross-sectional population-based cohort study of 1464 participants without overt cardiovascular disease was conducted. Dietary intake was assessed using a food frequency questionnaire. Arterial stiffness was assessed by carotid–femoral pulse wave velocity (cfPWV), and the FADS1 locus variant was determined. Blood cell transcriptomics was performed in a subset of 410 individuals. Pulse wave velocity was significantly associated with the FADS1 locus variant. Differential associations between PWV and omega-3 PUFA intake were observed depending on the FADS1 genotype. High omega-3 PUFA intake attenuated the FADS1 genotype-dependent associations. Carriers of the minor FADS1 locus variant exhibited increased expression of FADS2, which is associated with PWV.
Conclusion
Taken together, these findings point to FADS1 genotype-dependent associations of omega-3 PUFA intake on subclinical cardiovascular disease. These findings may have implications for identifying responders and non-responders to omega-3 PUFA supplementation and open up for personalized dietary counselling in cardiovascular prevention.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Bäck, Magnus; University of Lorraine, INSERM U1116, CIC 1433, FCRIN INI-CRCT, Nancy University Hospital, Nancy, France ; Department of Medicine Solna, Karolinska Institutet, 17176 Stockholm, Sweden ; Department of Cardiology, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
Xhaard, Constance; University of Lorraine, INSERM U1116, CIC 1433, FCRIN INI-CRCT, Nancy University Hospital, Nancy, France
Rouget, Raphael; Université de Lorraine, CNRS, UMR 7365, IMoPA, F54000 Nancy, France
Thuillier, Quentin; Université de Lorraine, CNRS, UMR 7365, IMoPA, F54000 Nancy, France
Plunde, Oscar; Department of Medicine Solna, Karolinska Institutet, 17176 Stockholm, Sweden
Larsson, Susanna C.; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden ; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Girerd, Nicolas; University of Lorraine, INSERM U1116, CIC 1433, FCRIN INI-CRCT, Nancy University Hospital, Nancy, France
Ferreira, João Pedro; University of Lorraine, INSERM U1116, CIC 1433, FCRIN INI-CRCT, Nancy University Hospital, Nancy, France
Boivin, Jean-Marc; University of Lorraine, INSERM U1116, CIC 1433, FCRIN INI-CRCT, Nancy University Hospital, Nancy, France
Bozec, Erwan; University of Lorraine, INSERM U1116, CIC 1433, FCRIN INI-CRCT, Nancy University Hospital, Nancy, France
Mercklé, Ludovic; University of Lorraine, INSERM U1116, CIC 1433, FCRIN INI-CRCT, Nancy University Hospital, Nancy, France
Zannad, Faiez ; University of Lorraine, INSERM U1116, CIC 1433, FCRIN INI-CRCT, Nancy University Hospital, Nancy, France
Hoge, Axelle ; Université de Liège - ULiège > Santé publique : de la Biostatistique à la Promotion de la Santé
Guillaume, Michèle ; Université de Liège - ULiège > Santé publique : de la Biostatistique à la Promotion de la Santé
Dandine-Roulland, Claire; Département des Sciences de la Santé publique, Université de Liège, Liège, Belgium
Floch, Edith Le; Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, Evry, France
Bacq-Daian, Delphine; Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, Evry, France
Deleuze, Jean-François ; Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, Evry, France
Van den Berghe, Laurie; Centre de Recherche en Nutrition Humaine Rhône-Alpes, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Hospices Civils de Lyon, F-CRIN/FORCE Network, Pierre Bénite, Lyon, France
Nazare, Julie-Anne; Centre de Recherche en Nutrition Humaine Rhône-Alpes, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Hospices Civils de Lyon, F-CRIN/FORCE Network, Pierre Bénite, Lyon, France
Laville, Martine; Centre de Recherche en Nutrition Humaine Rhône-Alpes, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Hospices Civils de Lyon, F-CRIN/FORCE Network, Pierre Bénite, Lyon, France
Branlant, Christiane; Université de Lorraine, CNRS, UMR 7365, IMoPA, F54000 Nancy, France
Behm-Ansmant, Isabelle ; Université de Lorraine, CNRS, UMR 7365, IMoPA, F54000 Nancy, France
Wagner, Sandra; University of Lorraine, INSERM U1116, CIC 1433, FCRIN INI-CRCT, Nancy University Hospital, Nancy, France
Rossignol, Patrick; University of Lorraine, INSERM U1116, CIC 1433, FCRIN INI-CRCT, Nancy University Hospital, Nancy, France
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