Effects of Citrulline alone or combined with exercise on muscle mass, muscle strength, and physical performance among older adults: a systematic review.
Aubertin-Leheudre, Mylène; Buckinx, Fanny
2020 • In Current Opinion in Clinical Nutrition and Metabolic Care, 23 (1), p. 8-16
[en] PURPOSE OF REVIEW: To Establish the potential of Citrulline supplementation (CIT) combined or not with exercise on muscle function and physical performance via a systematic review of randomized controlled trials (RCTs) in human aged 50 years and older.
RECENT FINDINGS: Based on Preferred Reporting Items for Systematic Reviews and Meta-analysis guideline, 103 references have been identified. Among this number, only six RCTs (250 participants) matched the inclusion criteria and were included in the present systematic review. Among the included studies, five of six reported beneficial effects of CIT on muscle mass. Then, four of six studies reported CIT effects on muscle strength but also that CIT when combined to exercise results in further improvements in upper muscle strength. Finally, three of six studies reported beneficial CIT effect on physical performance and suggested that CIT with exercise displayed greater improvements in walking speed than exercise alone.
SUMMARY: CIT supplementation seems to be able to improve muscular and physical factors in frail elderly people (malnourished, hypertensive, obese, dynapenic-obese) compared to placebo. More importantly, CIT combined to exercise is more efficient than exercise or CIT alone. However, because of the small number (six) and heterogeneity (dose, duration, population) of the studies realized in older adults, further studies are needed to confirm its promising potential.
Disciplines :
Geriatrics
Author, co-author :
Aubertin-Leheudre, Mylène; Department of Exercise Science, Groupe de recherche en activité physique adapté (GRAPA), Université du Québec à Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada WHO Collaborating Center for Public Health Aspects of Musculoskeletal Health and Ageing, University of Liège, Belgium
Buckinx, Fanny ; Université de Liège - ULiège > Unité de recherche Santé publique, épidémiologie et économie de la santé (URSAPES) ; Department of Exercise Science, Groupe de Recherche en Activité Physique Adapté (GRAPA), Université du Québec À, Montreal, Canada ; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada
Language :
English
Title :
Effects of Citrulline alone or combined with exercise on muscle mass, muscle strength, and physical performance among older adults: a systematic review.
Publication date :
2020
Journal title :
Current Opinion in Clinical Nutrition and Metabolic Care
Cruz-Jentoft AJ, Bahat G, Bauer J,. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48: 16-31.
Steffl M, Sima J, Shiells K,. The increase in healthcare costs associated with muscle weakness in older people without long-Term illnesses in the Czech Republic: results from the Survey of Health, Ageing and Retirement in Europe (SHARE). Clin Interv Aging 2017; 12: 2003-2007.
Le Plenier S, Goron A, Sotiropoulos A,. Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies. Am J Physiol Endocrinol Metab 2017; 312: E27-e36.
Joffin N, Jaubert AM, Durant S,. Citrulline induces fatty acid release selectively in visceral adipose tissue from old rats. Mol Nutr Food Res 2014; 58: 1765-1775.
Papadia C, Osowska S, Cynober L,. Citrulline in health and disease. Review on human studies. Clin Nutr 2017; 37: 1823-1828.
Bahri S, Zerrouk N, Aussel C,. Citrulline: from metabolism to therapeutic use. Nutrition 2013; 29: 479-484.
Moinard C, Le Plenier S, Noirez P,. Citrulline supplementation induces changes in body composition and limits age-related metabolic changes in healthy male rats. J Nutr 2015; 145: 1429-1437.
Joffin N, Jaubert AM, Durant S,. Citrulline counteracts overweight-And aging-related effects on adiponectin and leptin gene expression in rat white adipose tissue. Biochim Open 2015; 1: 1-5.
Ashley J, Kim Y, Gonzales JU,. Impact of l-citrulline supplementation on oxygen uptake kinetics during walking. Appl Physiol Nutr Metab 2018; 43: 631-637. This is the first RCT to test the hypothesis whether CIT would improve VO2 kinetics during walking in older and young adults
Figueroa A, Alvarez-Alvarado S, Ormsbee MJ,. Impact of L-citrulline supplementation and whole-body vibration training on arterial stiffness and leg muscle function in obese postmenopausal women with high blood pressure. Exp Gerontol 2015; 63: 35-40.
Buckinx F, Gouspillou G, Carvalho LP,. Effect of high-intensity interval training combined with L-citrulline supplementation on functional capacities and muscle function in dynapenic-obese older adults. J Clin Med 2018; 7: This is the first study that compares the effects of HIIT alone vs HIIT combined with CIT supplementation on functional capacities and muscle function in dynapenic-obese older adults.
Bouillanne O, Melchior JC, Faure C,. Impact of 3-week citrulline supplementation on postprandial protein metabolism in malnourished older patients: The Ciproage randomized controlled trial. Clin Nutr 2019; 38: 564-574. This is the first interventional study that research the effects of CIT supplementation on protein
Devries MC, Breen L, Von Allmen M,. Low-load resistance training during step-reduction attenuates declines in muscle mass and strength and enhances anabolic sensitivity in older men. Physiol Rep 2015; 3: pii: e12493.
Buckinx F, Gaudreau P, Marcangeli V,. Muscle adaptation in response to a high-intensity interval training in obese older adults: effect of daily protein intake distribution. Aging Clin Exp Res 2019; 31: 863-874. This is the first RCT that evaluate if the initial amount of daily protein intake could influence the combined effect of HIIT and CIT on functional capacities, physical endurance, muscle strength, power, and body composition in obese older men and women.
Buckinx F, Charles A, Quabron A,. Impact of frailty status on the cost of drugs and dietary supplements prescribed to nursing home residents: The SENIOR cohort. Aging Clin Exp Res 2019; 31: 875-880.
Villareal MO, Matsukawa T, Isoda H,. L-citrulline supplementation-increased skeletal muscle PGC-1alpha expression is associated with exercise performance and increased skeletal muscle weight. Mol Nutr Food Res 2018; e1701043. [Epub ahead of print].
Mangine GT, Gonzalez AM, Townsend JR,. Influence of baseline muscle strength and size measures on training adaptations in resistance-Trained men. Int J Exerc Sci 2018; 11: 198-213.
Bohannon RW,. Association of grip and knee extension strength with walking speed of older women receiving home-care physical therapy. J Frailty Aging 2015; 4: 181-183.
Barbat-Artigas S, Pinheiro Carvalho L, Rolland Y,. Muscle strength and body weight mediate the relationship between physical activity and usual gait speed. J Am Med Dir Assoc 2016; 17: 1031-1036.
Minnella EM, Awasthi R, Gillis C,. Patients with poor baseline walking capacity are most likely to improve their functional status with multimodal prehabilitation. Surgery 2016; 160: 1070-1079.
