Article (Scientific journals)
Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report
Lambert, Nicolas; El Moussaoui, Majdouline; Ritacco, Caroline et al.
2022In Frontiers in Immunology, 13, p. 889148
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Abstract :
[en] Treating patients with cancer complicated by severe opportunistic infections is particularly challenging since classical cancer treatments, such as chemotherapy, often induce profound immune suppression and, as a result, may favor infection progression. Little is known about the potential place of immune checkpoint inhibitors in these complex situations. Here, we report a 66-year-old man who was concomitantly diagnosed with non-small cell lung cancer and progressive multifocal leukoencephalopathy. The patient was treated with anti-PD-L1 antibody atezolizumab, which allowed effective control of both lung cancer and progressive multifocal leukoencephalopathy, as demonstrated by the patient’s remarkable neurologic clinical improvement, JC viral load reduction in his cerebrospinal fluid, regression of the brain lesions visualized through MRI, and the strict radiological stability of his cancer. In parallel, treatment with atezolizumab was associated with biological evidence of T-cell reinvigoration. Hence, our data suggest that immune checkpoint inhibitors may constitute a treatment option for patients with cancer complicated by severe opportunistic infections.
Disciplines :
Immunology & infectious disease
Author, co-author :
Lambert, Nicolas  ;  Université de Liège - ULiège > GIGA > GIGA Stem Cells - Molecular Regulation of Neurogenesis ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
El Moussaoui, Majdouline  ;  Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Maladies infectieuses et médecine interne générale ; Université de Liège - ULiège > GIGA > GIGA I3 - Immunology & Infectious Diseases
Ritacco, Caroline ;  Université de Liège - ULiège > GIGA > GIGA I3 - Hematology
MOISE, Martin ;  Université de Liège - ULiège > GIGA ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
PAULUS, Astrid ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
DELVENNE, Philippe ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Experimental Pathology ; Université de Liège - ULiège > Département des sciences précliniques MI > Anatomie et cytologie pathologiques
BARON, Frédéric  ;  Université de Liège - ULiège > GIGA > GIGA I3 - Hematology ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
SADZOT, Bernard ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
MAQUET, Pierre  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Language :
English
Title :
Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report
Publication date :
03 May 2022
Journal title :
Frontiers in Immunology
eISSN :
1664-3224
Publisher :
Frontiers Research Foundation, Lausanne, Switzerland
Volume :
13
Pages :
889148
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 May 2022

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